Báo cáo hóa học: " In vivo evidence of htid suppressive activity on ErbB-2 in breast cancers over expressing the receptor" potx

... suitable to in vivo dissect the oncosuppressive activity of the hTid proteins on ErbB-2 function. In view of the association of ErbB-2 over expression with poor prognosis in breast cancers the elu-cidation ... evidence that htid is a potential modulator of ErbB-2 signalling in both breast and non -breast tumors over expressing the kinase. Furthermore, since the inverse correlation of the expression levels of the ... In vivo evidence of htid suppressive activity on ErbB-2 in breast cancers over expressing the receptor Journal of Translational Medicine 2010, 8:58Kurzik-Dumke et al. Journal of Translational...

báo cáo hóa học: " Reliability and validity of a new scale on internal coherence (ICS) of cancer patients" pot

... individ-ual skills of adaptation detecting tool.There are significant limitations in our study in the lack of parallel recording of the SOC scale in the first and secondpart of the study. In unpublished ... role functioning and not in the scales beingstrongly correlated with the ICS, as emotional functioningand only at one point in the global health scale. Thiscould be related to the individual ... Matthes - hmatthes@havelhoehe.de* Corresponding author AbstractBackground: Current inventories on quality of life used in oncology mainly focus on functionalaspects of patients in the context...

Báo cáo khoa học: Site speciﬁcity of yeast histone acetyltransferase B complex in vivo pot

... levels of histonesduring the course of HU treatment.To investigate whether HU induces an increase of the Hat1 protein, we used a yeast strain expressing ahemagglutinin (HA)-tagged version of Hat1. ... for acetylation by the yeast HAT-B complex in vivo. Remarkably, the inability of the HAT-Bcomplex to acetylate histone H4 containing the K12Rsubstitution, both in vivo and in vitro, indicates ... complex. In any case, the presence of the HAT-B complex lacking histone H3 in the solublecell fraction would indicate that the interaction of histone H4 with the complex and its acetylation byHat1...

báo cáo hóa học:" Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells" pptx

... animalstreated with the LXR agonists (Figure 2B). In both rodentspecies, the magnitude of ABCA1 induction was signifi-cantly greater than the magnitude of ABCG1 induction. In rats, the induction of ABCA1 ... concentra-tion within these tissues cannot be easily monitored. Todetermine whether activation of gene expression in peripheral blood cells could provide insight into gene reg-ulation within ... bloodmononuclear cells express LXRα and LXRβ. Surprisingly,functional LXR expression was found in T- and B-cells aswell as in monocytes ex vivo. Evaluation of the transcrip-tional response of...

báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot

... participated in the design of the study and in draft-ing the manuscript. GT conceived of the research, was the main investigator and the coordinator of the study, made the statistics and drafted the ... corre-lating their concentrations to those present in chronichepatitis C (CHC), disease characterized by the combina-tion of apoptosis/inflammation and fibrosis, in whichTGF-β1 and iron overload ... for the noninvasively staging of NAFLD patients [23]. However,to date, none of these markers have been independentlyvalidated in different populations in a prospective way.Moreover, all of these...

báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot

... Biomed-ica. The funding sources had no role in the study design,collection, analysis, or interpretation of the data, or in the writing of the report. They also had no access to the rawTable ... perforin. Isotypematched controls were always included. The change of fre-quency for specific subset of cells during the post-vaccina-tion period is calculated by subtracting the basal value of pre-vaccination ... fold the mean SFU/well in wells contain-ing medium alone and the mean SFU/well in response toantigen was ≥ 10. A positive response was also required todemonstrate ≥ 2 fold increase after vaccination....

báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt

... ectopic site, the permeability of the BTB of the breast cancer tumor growing in the brain is lower than the BTB of the original tumor in breast tissue, the ortho-topic site[5]. The brain tissue ... of the high FA dynamic scandata sets. The Gd concentration in blood was determined in the common carotid arteries, since these were the larg-est caliber brain vessels in the imaging field -of- view. ... over 600 to 700 minutes. We com-pared the permeability of the BTB of RG-2 gliomas grownwithin the brain, the orthotopic site, to that of the BTB of RG-2 gliomas grown outside the brain in the...

báo cáo hóa học:" A novel role of HLA class I in the pathology of medulloblastoma" docx

... denaturedheavy chains [38], and W6/32 that binds to the combinedepitope contributed by the α2 and α3 domains of the heavy chain and β2m, dependent on the presence of pep-tides in the peptide-binding groove ... Nevertheless, the association of higher expres-sion of β2m with metastatic disease in a previous study of ours [35] is consistent with the findings of the presentstudy. Despite considerable evidence ... thereis a constitutive low level of ERK1/2 phosphorylation in the absence of any treatment, we refer to the effect of β2mas modulation, rather than induction of ERK1/2 phos-phorylation. Consistent...

báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot

... continued to be at the discretion of the attending physician, including ino-trope administration and dosing.ProceduresAll treatments including milrinone dosing was at the dis-cretion of the patient's ... markers, or whether high-sensitivity tro-ponin may reveal sub-clinical cardiac injury due to ino-trope initiation. We sought to determine the effect of initiating milrinone on biomarkers of myocardial ... milrinone and after 24 hours of infusion. Dosing was at the discretion of the patient's attending physician (range 0.25–0.5 mcg/kg/min). Plasma measurements of troponin, myoglobin, N-terminal-pro-BNP,...

báo cáo hóa học:" Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma" docx

... SPSS 13.0 software for Windows.ResultsIncrease in the expression of p53, p21/WAF1, and MDM2 in HCC The expression of p53 and MDM2 in the 7 pairs washigher in the HCC tissues than in the adjacent ... However, few of studies have investigated the p53protein expression in the liver tissues adjacent to the tumor in the same group of HCC patients. On the basis of our results, the comparison between ... performing immunohistochemistry and examined the expression of the 3 proteins in 7 pairs of HCC tissues and the adjacent hepatic tissues by using western blotanalysis.Results: The expression of...

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