... rapidly by the body, either through the skinor smoking, crosses the blood- brain barrier and stimu-lates nicotinic-cholinergic receptors of the CNS, causingan increase in heart rate, blood pressure ... Harrington Department of Bioengineering, Fulton School of Engineering ASU, Tempe AZ, USAFull list of author information is available at the end of the articleAkkurt et al. Journal of NeuroEngineering ... schizophrenia and the related neurobiological and genetic mechanisms as wellas the treatment of this disease with the use of nicotine,clozapine and the potential place of the new alpha7 nico-tinic receptor...