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báo cáo hóa học:" Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance" docx

báo cáo hóa học:

báo cáo hóa học:" Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance" docx

... CentralPage 1 of 14(page number not for citation purposes)Journal of Translational MedicineOpen AccessReview Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic ... of CLL cells, hence eventu-ally influencing the clinical aggressiveness of the disease,are divided into " ;intrinsic factors& quot;, mainly genomic alter-ations of CLL cells, and " ;extrinsic ... more than 15years. The pathogenetic factors playing a key role in defining the biological features of CLL cells,hence eventually influencing the clinical aggressiveness of the disease, are here...
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báo cáo hóa học:

báo cáo hóa học: " Social and dental status along the life course and oral health impacts in adolescents: a population-based birth cohort" ppt

... study, and the range of age differences may explain the different results. On the other hand, the epidemiolog-ical figures of oral diseases can significantly influence the pattern of the causes of ... conceived the study, performed the statistical analy-sis and interpretation of data, and drafted the manuscript.MAP participated in the collection, analysis and interpre-tation of data, and revising ... purposes)As all of the low-birth-weight children were included in the follow-up at 6 and 12 months of age and at 4 yr of age,they were equally over-represented in the OHS-6 (29.7%when compared with 10%...
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báo cáo hóa học:

báo cáo hóa học:"Necessary and sufficient condition for the smoothness of intersection local time of subfractional Brownian motions" docx

... completes the proof of Theorem 2. 4. Smoothness of the intersection local timeIn this section, we consider the smoothness of the intersection localtime. Our main object is to explain and prove the ... Existence of the intersection local time The aim of this section is to prove the existence of the intersectionlocal time of SH and SH, for an H =12 and d ≥ 2. We have obtained the following ... following theorem. The idea is due to An and Yan [32] and Chen and Yan [7].Theorem 5. Let Tbe the intersection local time of two independentd-dimensional sub-fBms SH and SH with indices...
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Báo cáo y học:

Báo cáo y học: "PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells"

... Liebner S., Andbjer B., Kalbacher H., Wolburg H., Haller H., and Fuxe K. Organization of choroid plexus epithe-lial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression ... analysis, these transfectants demonstrate the presence of claudin-1 protein in the cytoplasm, with small amounts in the nucleus. When cells are transfected with CLDN1 under the control of a nuclear ... signal (CLDN1-NLS), there is increased expression of claudin-1 in the nucleus, but there are still large amounts of claudin-1 in the cytoplasm as well. B) All of the claudin-1 in the nucleus can...
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Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx

Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx

... atoms of Ala59 and Glu61 of one subunit and with the main chain nitro-gen of Asn114¢ of the other subunit. The contacts of the ribityl chain to His89 and Lys138¢ are mediated bya net of water ... behaviour of the binding sites withina pentamer which depends on the specific nature of the inhibitor molecule, particularly depending on the length of the alkyl phosphate chain and the ability of the ... to the periphery of the act-ive site is restricted by the position of Arg128 fromone side and the conformation of the loop connectingb4 with a3 (residues 85–88) from the other side. Inthe...
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Báo cáo Y học: Kinetic and biochemical analyses on the reaction mechanism of a bacterial ATP-citrate lyase ppt

Báo cáo Y học: Kinetic and biochemical analyses on the reaction mechanism of a bacterial ATP-citrate lyase ppt

... steps that govern the nucleotidedependency of the enzyme and the inhibition observed with ADP.MATERIALS AND METHODSPurification of the recombinantCl-ACLConstruction of the expression vector ... decreased the affinity of the enzyme for the second molecule by a factor of 23. ADPwas a competitive inhibitor of ATP with a Kivalue of 0.037 ± 0.006 mM. Together with previous findings that the enzyme ... is the initial velocity of the reaction, Vmaxis the maximum velocity, [S] is the concentration of citrate, Ksis the dissociation constant of the enzyme-citrate (ES) com-plex, and a, b, and...
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Báo cáo khoa học: Temperature and salts effects on the peptidase activities of the recombinant metallooligopeptidases neurolysin and thimet oligopeptidase pdf

Báo cáo khoa học: Temperature and salts effects on the peptidase activities of the recombinant metallooligopeptidases neurolysin and thimet oligopeptidase pdf

... verify the influence of the nature of the amino acid at this position ondetermination of the cleavage sites and on the amount of their hydrolysis. This series of peptides was chosen because the ... of hydrolysis and the variations of the cleavage sites wereevaluated under different conditions of temperature and salt concentration. The relative amount of cleavage varied with the nature of the substitution ... of the velocities of formation of the products (Pa and Pb). Vamaxis kpa· [E] and Vbmaxis kpb· [E], and [E] is the total enzyme concentration in the assay. All the obtaineddata with...
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báo cáo hóa học:

báo cáo hóa học:" Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells" pptx

... accumulation in these cells,through the uptake of oxLDL/LDL, is believed to be of fundamental importance to the etiology and pathogenesis of atherogenesis and atherosclerosis and other chronic inflammatory ... treated with arange of doses of GW3965 (Figure 2D) or LXR-623 (Figure2E). Since the potency of these ligands for activation of ratLXRα or LXRβ is not known, the potency for activation of ABCA1 ... to the plate, the lysed cells were scrapedfrom the plate with a cell lifter, and the lysed cells in RLTbuffer were transferred to the cell pellet from the centri-fuged conditioned media. The...
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báo cáo hóa học:

báo cáo hóa học:" MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells" doc

... cells[20] orSequence and GO analysis of the miR-302 cluster and miR-520 clusterFigure 8Sequence and GO analysis of the miR-302 cluster and miR-520 cluster. The members of the miR-302 and miR-520 clusters ... as the reference for the miRNA expressionarray assay. The test sample was labelled with Hy5 and the reference with Hy3. After labelling, the sample and the ref-erence were co-hybridized to the ... collected and analyzed the data and wrote the manuscript. PJ carried outdata analyses and assisted with writing the manuscript.EW designed the miRNA-array and oligo platform, devel-oped protocol and...
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báo cáo hóa học:

báo cáo hóa học:" Acetaldehyde and hexanaldehyde from cultured white cells" pot

... exception of acetaldehyde and hexanaldehyde,all other gases quantified in the headspace of the HL60cells were either near the detection limit of the GC-MS sys-tem, or were evolved solely from the ... illustrating the time-dependent increase of acetaldehyde concentration in the headspace above the HL60 cells. The asymmetry of the acetaldehyde peak is aresult of the oxygenate's interaction with the ... used to flush the headspace of the bioreactors containing vials of media and HL60 prior to incubation. An equal volume of air was analyzed in each of the three chromatograms.Journal of Translational...
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