báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14 18-IL2) in patients with metastatic malignant melanoma" docx
báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma" docx
... biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14. 18-IL2) in patients with metastatic malignant melanomaAntoni Ribas1, John M Kirkwood2, Michael B Atkins3, Theresa ... response. The main finding of this study was anincrease in intratumoral CD8+ CTL with possibleincreased expression of CD3zeta and granzyme B afteradministration of EMD 273063. Since these results ... absence of macroscopic tumor does not influence the clearance of EMD 273063 [7]. In our study, the safetyprofile of EMD 273063 was consistent with the expectedIL2 side effect profile as reported in...
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báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot
... 0.0206).DiscussionThis study established the safety and feasibility of com-bining vaccination with MVA expressing 5T4 and high-dose IL-2 in patients with metastatic RCC. The trial wasTable 3: ... Yang JC, White DE, Steinberg SM: Durability of complete responses in patients with metastatic cancertreated with high-dose interleukin-2: identification of the antigens mediating response. Ann Surg ... Tregs in our patients. We previously reported that Tregs are increased in metastatic RCC patients but decreased to normal levels in those patients responding to IL-2 therapy [15]. In the current study, ...
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Báo cáo hóa học: " Phase I clinical trial of the vaccination for the patients with metastatic melanoma using gp100derived epitope peptide " pot
... wereinduced with the gp100 -in4 stimulation on the PBMCstaken from the patients (P1, P2, P3, and P4) after the vaccination. The PBMCs of P1 showed an incrementalincrease in the frequency of induced ... IFN-g-producingcells in association with the number of the vaccinations. In P2, a significant increase of the frequency of induc-tion of IFN-g-producing cells was observed during the Figure ... side of each panel. The arrowindicates the timing of each vaccine injection. In ELISPOT assay, to evaluate the characteristics of peptide-specific CTLs, PBMCs of the patients were stimulated in...
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báo cáo hóa học:" Gene expression profiling for molecular distinction and characterization of laser captured primary lung cancers" ppt
... wasinvolved in the tumor sample collection. AVH and MRwere involved in the statistical analysis of the data. JN, GGand MS were involved in the data collection of the patients, and in the review ... removed from the training set. The other samples are reduced to those 50genes with the highest signal-to-noise ratio, which areused as a training set in a training series. A training seriesgenerates ... spreading. The extracellular cell matrix receptors integrin alpha-3 andintegrin beta-2 as well as the collagen binding protein-1(SERPHINH1) were upregulated in AC. These genes havea high affinity...
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báo cáo hóa học:" Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells" potx
... anti-inflammatory property targeting atdifferent levels of TNF-α activity. The anti-inflammatory role of ginseng may be due to the combined effects of ginsenosides, contributing in part to the ... present in significant concentrations may modulate the activity of the ginsenosides.We then investigated the combinatorial effect of the nineginsenosides on TNF-α induced-CXCL-10 transcription. The ... reported in this study. Cells with TNF-α or PGSE treatment only were included, and the fold induction of cytokines in cells with treatment wasnormalized with that of the untreated cells.Following the...
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báo cáo hóa học: " Primary Sjögren''''s Syndrome: health experiences and predictors of health quality among patients in the United States" potx
... data was obtained using the summaryPROF, PROFAD and SSI indices. Principal componentanalysis was used to investigate the internal structure of the PROFAD-SSI. Facet scores rather than individual ... design of the study. FVparticipated in the design of the study. NM participated in the design of the methodology, managed data collection,conducted some of the analyses, and drafted sections of this ... PSSaccording to the eligibility criteria. Since the diagnosis of PSS could not be directly confirmed in the SSF patientgroup, these data were not included in the analysis, how-ever we found that the...
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báo cáo hóa học: " Associations between Cardiorespiratory Fitness and Health-Related Quality of Life" pdf
... health-related quality of life.HRQOL is defined as the perception of overall satisfaction with life and involves the measurement of functional sta-tus in the domains of physical, cognitive, ... rate during the submaximal graded exercise test,or were missing any data required for the analysis. Anyparticipant who reported smoking on the morning of the HFA was excluded from the database ... limitation influencingmotivation. The final limitation of our study is that sub-maximal testing was used to estimate maximal MET level.However, in its scientific statement on the Assessment of Functional...
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Báo cáo hóa học: " Kinematic variability, fractal dynamics and local dynamic stability of treadmill walking" ppt
... erval, by analogy totheconstraintinducedbyametronome;2)thatTWmay increase the local dynamic stability of walking, dueto the diminution of degrees of freedom in the moreconstrained artificial e ... exponentrequires intensive computing power, 7 min of the 10 min walking test (from 1.5 to 8.5 min.) was selectedand the raw data were down-sampled to 100 Hz. The determination of the Lyapunov exponent was thenachieved ... and changes in visua l and vestibu-lar perceptual information. In light of the results of the present study, we hypothesize that motor control is ableto maintain the same range of kinematic variability...
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Báo cáo hóa học: " Biomechanical energy harvesting from human motion: theory, state of the art, design guidelines, and future directions" docx
... the stance phase (the phase in which the foot ison the ground). Others use the energy from the bending of the shoe sole. In both cases, the device aims to use the energy that would otherwise have ... However, therewere certain d rawbacks associated with this device in that it used only a small part of the motion of the knee(end of the swing phase) to generate energy: During the gait cycle, the ... the currently available knee device works only at the swing phase; thus, all the phases of negative workduring the g ait cycle are not utilized. The main chal-lenges in harvesting all the phases...
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báo cáo hóa học: " Vision based interface system for hands free control of an intelligent wheelchair" ppt
... forward, therebypreventing over-recognition when user is talking to some-one. Plus the direction of the IW is determined by the inclination of the user's face instead of the direction of the user's ... abilities, the proposed system involves the use of face-inclination and mouth-shape information, where the direction of an IW is determinedby the inclination of the user's face, while proceeding ... streaming of the user sitting on the wheelchair in front of the computer. Then, the proposed interfaceallows the user to control the wheelchair directly bychanging their face inclination and...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngChuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Chiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015MÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ