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báo cáo hóa học:" Of gastro and the gold standard: evaluation and policy implications of norovirus test performance for outbreak detection" ppt

báo cáo hóa học:

báo cáo hóa học:" Of gastro and the gold standard: evaluation and policy implications of norovirus test performance for outbreak detection" ppt

... of 9(page number not for citation purposes)Journal of Translational MedicineOpen AccessResearch Of gastro and the gold standard: evaluation and policy implications of norovirus test performance ... the test performance for real-time reverse-tran-scriptase (RT2-) PCR, EM, and EIA for norovirus usingboth LCM and CRS; and (ii) to evaluate the implications of these characteristics for outbreak ... summary, the absence of a traditional " ;gold standard" for the evaluation of test characteristics in the identifica-tion of NVG outbreaks does not preclude rational evalua-tion of the test...
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Báo cáo hóa học: " Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits" pot

... 4 of 12sations. Rabbits # 50, 62 and 83 died before the fifth prim-ing for natural reasons and do not appear in all of the tests. Bleedings were performed before each immunisa-tion, from the ... FPwt-infected Vero cells and tested for the presence of antibodies against the HPV-16 E6 and E7 proteinsbefore the first and after each immunisation. The ELISAwas essentially performed as previously ... dividing the differencebetween the mean counts per minute of experimental and spontaneous release, by the difference between the mean counts per minute of the total and spontaneousrelease. For the...
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Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish pdf

Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish pdf

... with the discovery of a dmrt1homologue on the Y chromosome of the fish medaka(Oryzias latipes). This Y-chromosomal gene is the product of a gene duplication of the autosomal dmrt1agene and was ... has all the features of the master regula-tor of testicular differentiation in medaka (see [13] for review) and because of the discovery of sex-chromo-some-linked dmrt1s in other vertebrates (DM-W ... birds, mammals and corals is the dmrt genefamily [5]. The prototype members of this group of factors are the Drosophila doublesex (dsx) and Caenor-habditis mab-3 genes. The Dmrt group of molecules...
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Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt

Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt

... erva-tamin-A, the P3 moiety of both the molecules of the asymmetric unit runs along the extended backbone of residues 65–64 and is partly exposed to the solvent(Fig. 2B). On the other hand, the P3 ... tool in the study of mechanism exemplified by a comparison of the cata-lytic-site structure and characteristics of cathepsin B and papain. pH-dependent kinetics of the reactions of cathepsin ... of the enzyme, which has the catalytic siteat the interface of the two domains. This observationhelps us to improve our understanding of the genericprinciple of catalysis for this family of...
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Báo cáo khoa học: Peptides that bind the HIV-1 integrase and modulate its enzymatic activity – kinetic studies and mode of action pptx

Báo cáo khoa học: Peptides that bind the HIV-1 integrase and modulate its enzymatic activity – kinetic studies and mode of action pptx

... dissoci-ation of the IN multimer molecule [70]. The breakpoint observed in several of the panels of Fig. 4 is the optimum point of the reaction, namely the ideal con-centrations of DNA, peptide and amount ... wereperformed to study the mode of action of these peptides. The effects of the various peptides on the interaction between IN and its substrate DNA werealso studied by fluorescence anisotropy. On the ... increased the Km of the IN–DNA interaction, and were thus inhibitory; (b) peptides that slightly increased the Km of the IN–DNA interaction, but in addition modified the Vmax and Kcatvalues of the...
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báo cáo hóa học:" More insights into the immunosuppressive potential of tumor exosomes" pptx

... Finally in 1996 these micropar-ticles were recognized for their central role in antigen pres-entation with the work of Graça Raposo and Hans Geuze of Utrecht University in the Netherlands, who reportedthat ... cellcross-priming through the expression of HLA/peptidecomplexes [6]. Based on these and following observationsabout the role of exosomes in antigen presentation, the exacerbated production of these vesicles ... exosomes, and CEA and HER2 inexosomes produced by carcinoma cells [9-11], supported the role of these organelles as cell-free source of tumorantigens for T cell priming and paved the way to...
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báo cáo hóa học:

báo cáo hóa học:" Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients" pot

... the design of the study and performed the evaluation of the data. TT helped to draft the manuscript. SI contributed to the HLA-A24-binding assay and CTL induction fromPBMCs. AM, AY and HH contributed ... collectingpatients' samples with the informed consent. HH and NScontributed to the design and coordination of this studyas well as reviewing the manuscript. All authors have read and approved the final manuscript.AcknowledgementsWe ... westimulated PBMCs of oral cancer patients with either orboth Survivin-C58 and Survivin-2B80-88 peptides, and the consequent CTLs were examined for the peptide-spe-cificity and cytotoxicity against...
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báo cáo hóa học:" Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma" ppt

... cancers and the high affinity of the ligands for the receptor may present aunique opportunity to utilize these ligands as chemother-apeutic sensitizers.We hypothesized that sigma-2 ligands may ... conven-tional therapies for pancreas cancer and are an excitingclass of compounds for potential treatment of thesemalignancies.MethodsSigma receptor ligandsSigma-2 specific ligands SV119, SV95, and ... stemsfrom the difficulty in achieving an early diagnosis and the failure of surgery, radiation and chemotherapy. In fact,only 15% of patients are eligible for surgical resection at the time of diagnosis...
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báo cáo hóa học:

báo cáo hóa học:" Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson''''s disease" doc

... assay.HPLC analysis of the synthesis and release of DA by RPE cellsFigure 5HPLC analysis of the synthesis and release of DA by RPE cells.(A) HPLC analysis of standard of DA, 3,4-dihy-droxyphenylacetic ... sepa-rated and cultured by QG. DY, LL and SC gave advises on the work and helped in the interpretation of the data. WLsupervised all the work and wrote the paper together withMM. All authors read and ... counted using a field lens, and the size of field was 4 mm2 and 10 fields consisted of about 35% of the whole surface of the cultured well. For 6-OHDA treatment, the VM cultures were treatedunder...
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Báo cáo hóa học:

Báo cáo hóa học: " Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients" docx

... TM and PMW carriedout the experimental work including the extraction of RNA, validation of microarray data by real-time PCR and the analysis of serum samples. The microarray experiment and the ... compared. The analysis of geneexpression patterns at the onset of surgery allowed for the identification of changes resulting from the precondition-Table 1: Forward and reverse primers used for real-time ... recruitment and, therefore, was excluded from the study.Preconditioning protocolAll patients had a tourniquet placed on the upper thigh of the operative limb after the administration of spinalanaesthesia...
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