... signaling processes. The ligation of VEGFR-2 by
the majority of VEGF isoforms triggers the proliferation,
migration and survival of endothelial cells, which in
tumors form the framework of immature new ... Ab alone or in combination with
other modalities to treat murine tumors. Activation of vas-
culature in tumors, extravasation and proliferation of T
cells, and inc...
... science, development and application of
biological therapy and immunotherapy. The society and its educational programs have become premier
destinations for interaction and innovation in the cancer biologics ... Primer on Tumor Immunol-
ogy and Biological Therap y of Cancer™ provided a
comprehensive overview of the principles of immunol-
ogy, with the aim...
... HIV
infection and autoimmune diseases. The depletion of the
CD4 T lymphocytes is the hallmark of the progression of
HIV infection and, in the absence of antiviral treatment,
the main contributor to the ... docking into a conserved hydro-
phobic pocket, a discontinuous region at the interface
between the inner and the outer domain of gp120 [52].
On the ot...
... also
performed to find the appropriate serum dilution able to
saturate alternatively one of the two CaSki antigens, and
determine the relative contribution of each immunogen.
The sera of the E6- and E7-immunised ... infection and the appearance of cervi-
cal intra-epithelial neoplasias, the long-term durability of
the protection by these vaccines has not yet be...
... modification in the HI loop and mutation of
the fiber shaft KKTK domain to GATK (the HSPG
binding ablation) showed reduced liver and spleen trans-
duction in compari son with wild type virus. This
demonstrates ... MR
images was done by JH and SLA and quantification of tumor volumes and
subsequent analysis of the data by SLA. Statistical calculations were
performed by...
... approaches to the
validation of known immune response biomarkers and
the standardization of the respective assays to enhance the
likelihood of obtaining informative returns from ongoing
immunotherapy ... institutions. This
working group will focus primarily on the standardization
and corroboration of commonly utilized assays for meas-
urement of host -tumor interact...
... results.
The apoptotic effect of the sigma-2 ligand, SV119, is enhanced by conventional chemotherapy in vitroFigure 2
The apoptotic effect of the sigma-2 ligand, SV119, is
enhanced by conventional ... the sigma-2 ligand, SV119, is enhanced by conventional chemotherapy in vivoFigure 4
The pro-apoptotic activity of the sigma-2 ligand,
SV119, is enhanced by conventional che...
... sepa-
rated and cultured by QG. DY, LL and SC gave advises on
the work and helped in the interpretation of the data. WL
supervised all the work and wrote the paper together with
MM. All authors read and ...
rotenone. (D) The number of TH-ir neurons in the cultures
treated with fresh medium only (Control), with fresh
medium in the presence of 25 nM rotenone...
... presentation.
DJD, ST and BBF provided advice on the conception and design of the
clinical and animal experiments. DPS and REWH were imperative to the
conception, design and implementation of the experiments ... functions such as cellul ar recruitment, despite
the severe impairment of the expression of other family
members. As demonstrated here, the expressio...
... as the first
line chemotherapy. The results showed that the expres-
sion level of polh in tumor cell lines was correlated with
the sensitivity of oxaliplatin (Figure 2). For the tumor
tissue, the ... expression only occurred in 28.75%
cases (23 out of 80), and the expression was modest.
However, strong correlation was found between polh
expression and treatment res...