báo cáo hóa học:"Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells" pdf

... purposes)Journal of Translational MedicineOpen AccessResearchInterdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cellsKeith M Skubitz*1 and Amy PN Skubitz2Address: ... on neutrophil adhesion to endothelial cellsBecause CEACAM-1, -3, -6, and -8 are highly homologousstructurally, and can undergo a number of differenthomotypic and heterotypic adhesion reactions ... ligation of CEACAM-1, -8, -6, and -3 byCD66a, CD66b, CD66c, and CD66d mAbs, respectively,transduce signals in neutrophils resulting in activation of CD11/CD18, and an increase in neutrophil adhesion...

Báo cáo hóa học: " Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys'''' pot

... of Ab-01 and Ab-02 to cynomolgus monkey IL-21R are similar to therespective values for human IL-21R. To support preclini-cal development of Ab-01 and Ab-02, pharmacokinetic(PK) profiles of ... thetreatment of a variety of autoimmune diseases.Ab-01 and Ab-02 are human neutralizing anti-IL-21Rantibodies generated by phage display technology. Ab-01 and Ab-02 bind to the same epitope on the human ... duration of PD activity. Thus,slower koff rate leading to a lower KD value for in vitrobinding to human IL-21R of Ab-02 (~0.4 nM) compared to Ab-01 (~2 nM) did not translate into an improved...

Báo cáo hóa học: "Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients" ppt

... expansion of these cells, which lackingCCR7 expression have the capacity to migrate to inflam-mation sites and to produce large amounts of proin-flammatory cytokines, may be one of the r easons of ... EA:Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations insuspect lymphoproliferations: report of the BIOMED-2 ... TRECs was serially diluted into DNA of a human lymphoblastoid cell line to obtain final concen-trations of normal lymphocyte DNA ranging from 3% to 100%. While KRECs and TRECs were undetectable...

Báo cáo hóa học: " Comparison of the self-administered and interviewer-administered modes of the child-OIDP" ppt

... AbstractBackground: The mode of questionnaire administration may affect the estimates and applicability of oral health-related quality of life indicators. The aim of this study was to comparepsychometrically ... MedicalEthics Committee, the Research and Development Panel of the Bedfordshire Heartlands Primary Care Trust and theResearch and Development Directorate of the UniversityCollege London Hospitals ... settings and disease profiles of thesamples limit comparability of our results with the afore-mentioned studies.Table 4: Comparison of internal reliability between face -to- face interview (FTFI) and...

Báo cáo khoa học: Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting pdf

... 5177store-operated channels and IP3 receptors with 2-APB(Fig. 6A). In the absence of extracellular calcium or inthe presence of both calcium and 2-APB, the weakresponses of copines-3 and -6 to ... 238–248.15 Cowland JB, Carter D, Bjerregaard MD, Johnsen AH,Borregaard N & Lollike K (2003) Tissue expression of copines and isolation of copines I and III from thecytosol of human neutrophils. ... chimaera of the C2C2-domains of copine-2 and the vWA-domain of copine-6; C2A6*, chimaera of the C2C2-domains of copine-2 and the vWA-domain of copine-6 with the copine-6 linker; C6A2, chimaera of the...

Báo cáo khoa học: Lithium increases PGC-1a expression and mitochondrial biogenesis in primary bovine aortic endothelial cells ppt

... [18].Both GSK3b and p53 have been shown to localize to mitochondria. GSK3b was localized to the mito-chondria of cerebellar cells [19] and enrichment of act-ive GSK3b in mitochondria and nuclei ... increaseexpression of the mitochondrial biogenesis markers.However, mRNA levels of the nuclear genes ATP syn-thase-b, cytochrome oxidase VIc and TFAM, and of the mitochondrial genes ATP synthase-6 and cyto-chrome ... effects of varioussubstances and factors in brain, heart and vesselischemic–reperfusion injuries also seem to be mediatedin part by an increase in mitochondrial biogenesis and preservation of mitochondrial...

Tài liệu Báo cáo khoa học: Characterization of promoter 3 of the human thromboxane A2 receptor gene A functional AP-1 and octamer motif are required for basal promoter activity docx

... Prm3b ()975 to +1), Prm3a ()404 to +1),Prm3ab ()320 to +1), Prm3aa ()154 to +1), Prm3aab ()106 to +1) and 3aaa ()50 to +1) were subcloned into pGL3Basic (A and C) orpGL3Enhancer (B and D). Resulting ... between )154 to )106 and )50 to +1, wereidentiﬁed within the core Prm3. Deletion and site-directed mutagenesis of consensus Oct-1 ⁄ 2 and AP-1 elements within the latter )154 to )106 and )50 to +1 ... Prm3aa ()154 to +1), Prm3ax () 140 to +1), Prm3ac ()119 to +1) and Prm3aab ()330 to +1) (A) orPrm3a ()404 to +1) or Prm3ab ()320 to +1) and their site-directed variants Prm3aOct-1* and Prm3abOct-1*,...

Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx

... in normal and cataractous human lenses. Exp. Eye Res. 25,139–148.59. Garner, M.H. & Spector, A. (1980) Selective oxidation of cysteine and methionine in normal and senile cataractous lenses. ... inactivation of GAPDH and GR occurs via oxidation of nonactive siteresidues, that bring about loss of functional integrity, thestoichiometry of inactivation ( i.e. the loss of two molecules of thiol ... photo-oxidativedamage and cell death [62,63]. Whether the p rotectionoffered by thiols is o wing to direct scavenging of 1O2,removal of peroxides (H2O2 and/ or protein), or repair of reversibly...

Tài liệu Báo cáo Y học: Uncoupling of protein-3 induces an uncontrolled uncoupling of mitochondria after expression in muscle derived L6 cells ppt

... facilitate thedocking of the precursor proteins of the mitochondrial Pi and the ADP/ATP carriers on the Tom70–Tom37 complex,an import receptor localized on the outer mitochondrialmembrane. ... yeast mitochondria, the protein was found to be fully functional and to be regulated by FFAs and nucleotides, s imilarly to when expressed i n i ts nativelocation, the mitochondria of the brown ... the level of proton leak of mitochondria, the low l evel of respiration inthe presence of oligomycin of L6 cells showed that they werevery well coupled. The oligomycin resistant respiratoryactivity...

Báo cáo khoa học: Interaction of caspase-3 with the cyclic GMP binding cyclic GMP speciﬁc phosphodiesterase (PDE5a1) potx

... of apoptosis in B cells. Scan.J.Immunol.43, 406–412.28. Tortorella, C., Piazzolla, G., Spaccavento, F. & Antonaci, S.(1998) Eﬀects of granulocyte-macrophage colony-stimulatingfactor and ... Biology, Institute of Biological and Life Sciences, University of Glasgow, Scotland;5Department of Molecular Biology, Institute of Biotechnology, Flanders Interuniversity, University of Ghent, BelgiumHere, ... the proteases of the apoptotic pathway. Oncogene 17,3237–3245.17. Alnemri, E.S., Fernandes-Alnemri, T. & Litwack, G. (1995)Cloning and expression of four novel isoforms of human inter-leukin-1...

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