... tissue-specific APssuch as intestinal-type AP (IAP), placental-type AP(PLAP), and germ cell-type AP (GCAP) [9,10]. Notissue-specific APs have, to date, been found in inver-tebrates. IAP was a ... metal-binding site 3; PLAP, placental alkaline phosphatase; rIAP,rat intestinal alkaline phosphatase; SAP, shrimp alkaline phosphatase; TNAP, tissue-nonspecific alkaline phosphatase.FEBS Journal ... those seen in human placental alkaline phosphatase (hPLAP), and the orange sticks with red tips represent PO4. The posi-tions of the metal, represented by a brown sphere, and of PO4, were constructed...