... efficacy and safety assessments used in this study were standard for OA and are widely used and recognized as reliable, accurate, and relevant. WOMAC scores were determined, at screening, and ... rate, and pulse rate), and liver (bilirubin, GGT, and ALP) and kidney (BUN and creatinine) functions were not affected by UC-II treatment, suggesting that UC-II is well toler-ated and does ... ran-domization and during the study, were not allowed. Treatment compliance Compliance was assessed by capsule count at visits 3, 4, and 5 and review of subject diary. Efficacy and Safety Variables...