... elimination half-life of lamotrigine isprolonged in renal failure, and dosing may need to bemodified based on the creatinine clearance [72,73].Gabapentin clearance is linearly related to creatinineclearance ... portacaval shunting, thereby decreasing first passmetabolism; decrease in quantities and affinity of plasmaproteins, thereby increasing free-drug levels; increase involume of distribution in patients ... syndrome), including carbamazepine, phenytoin,phenobarbital, and lamotrigine. The triad of hypersensi-tivity includes fever, rash and internal organ involvementwith onset of symptoms within 1 to...