... However, cellularCa2+transients also have a spatial dimension. In thecytoplasm of single cells, C a2+gradients can be observedwhen Ca2+release from the ER is excited at particularsubcellular ... the cells oscillating faster in isolationpeak before the slower cells. Thus the intercellular couplingleads to a (near) 1 : 1 entrainment, or synchrony, of theoscillations in adjacent cells. ... [197]. Intercellular entrainment of Ca2+oscillationshas also been observed i n other cell types, such aspancreatic acinar cells [198], articular chondrocytes[199,200], kidney cells [201],...