... 317
CHAPTER 13
Federal Oversight of Gene Therapy
Research
THOMAS F. KRESINA, PH.D.
BACKGROUND
Federal oversight of biomedical research is an evolving regulatory activity of the
federal government. Federally ... recombinant
DNA, gene transfer, genetic testing, and xenotransplantation.
304 FEDERAL OVERSIGHT OF GENE THERAPY RESEARCH
OFFICE OF BIOTECHNOLOGY...
... the deletion of the E1
and E2b genes and the use of homologous (rat) BMP
genes do not improve the osteogenic potential of
direct BMP adenovirus vector gene therapy, the
results of this study ... findings of
this experiment, accurate gene sequencing is also a
critical factor in the determination of the fate of gene
expression. Any mismatched base pair may lead to th...
... Smith lectures in genetics and physiology in the School of Contemporary
Sciences, University of Abertay, Dundee, United Kingdom. His research interests
include transgenesis, gene therapy and bioethics. ... event in a clinical trial of
gene therapy for X-linked severe combined immune deficiency (X-SCID) - Position statement from the
European Society of Gene Therapy (ES...
... Naldini
2
1
Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II; Italy
2
Laboratory for Gene Transfer
and Therapy, Institute for Cancer Research and Treatment, University of ... detection of
fluorescence after infection of MPS I cells with 20 ng
of lentiviral-GFP; efficiency was calculated as number of
Fig. 1. Diagram of lentiviral vecto...
... is the manipulation of these genetic mutations and the enhancement of normal
cellular events that is the goal of cancer gene therapy. Thus, gene therapy for the
treatment of cancer has been directed ... understanding of gene regulation, apoptosis, and the synergy between
gene therapy and chemotherapy will augment the approaches for gene- based
therapy of cancer.
KE...
... viral gene expres-
sion to avoid cytotoxic and immunological effects. The exclusion of these genes,
however, often reduces the efficiency and length of transgene expression. Control
of the gene ... encourage cell survival form the basis of gene therapy
in the nervous system. As gene therapy approaches are developed and refined,
the outcome of gene therapy in the nervou...
... Freeman 479
31 Gene Therapy for Treatment of Brain Tumors
(
HSV-tK
In Vivo Gene Transfer):
A Case Study
Friedrich Weber, Frank Floeth, and Hans Bojar 499
x Contents
32 Gene Therapy of Glioblastoma ... 511
33 Intratumoral Gene Transfer of the Cytosine Deaminase Gene
for the Treatment of Breast Cancer
Hardev S. Pandha and Nicholas R. Lemoine 523
C:
Anti-Oncogene and Supp...
... dục.
nguyenthanhloi_2@yahoo.com 54
TRƯỜNG ĐH TÂY NGUYÊN
KHOA KHTN & CN
LIỆU PHÁP GEN
(Human Gene Therapy)
GVHD: Võ Thị Phương Khanh
SVTH: Nguyễn Thành Lợi
Hồ Thị Lan Anh
Nguyễn Thị Trang
nguyenthanhloi_2@yahoo.com ... bắn
gen, các vi đạn có
bọc gen liệu pháp
để đưa vào tế bào
đích
Kỹ thuật dùng súng bắn gen (gene gun):
nguyenthanhloi_2@yahoo.com 14
Kỹ thuật liposom (liposom te...
... real-time analysis of accumulation of multiple products to
provide more sophisticated information on relative levels of different gene
transcripts. Changes in gene expression of even more genes can be ... success of both the DNA elution and re-amplification
depends on the amount of cDNA generated during the first round of PCR.
A good way of optimizing the first round PCR is t...