... first identified in budding yeast, leading to the discov-ery of highly conserved MAD (mitotic arrest deficient) and BUB (budding uninhibitedby benzamidazol) genes, encoding the spindle-assembly ... Catarin, B., Herskowitz, I., Deshaies, R. J., and Peter, M. (1997)Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase in- hibitor Far1p in budding yeast. Genes Dev. ... Rum1), and replication proteins (Cdc6 and Cdc18; reviewed in ref.55). SCF was first identified in budding yeast, where it was found that mutants in Cdc53, Cdc4, and Cdc34 failed to degrade Sic1p...