Báo cáo Y học: Refolding of the Escherichia coli expressed extracellular domain of a7 nicotinic acetylcholine receptor Cys116 mutation diminishes aggregation and stabilizes the b structure pdf
Báo cáo Y học: Refolding of the Escherichia coli expressed extracellular domain of a7 nicotinic acetylcholine receptor Cys116 mutation diminishes aggregation and stabilizes the b structure pdf
... Refolding < /b> of < /b> the< /b> Escherichia < /b> coli< /b> expressed < /b> extracellular < /b> domain < /b> of < /b> a7 < /b> nicotinic < /b> acetylcholine < /b> receptor< /b> Cys116 < /b> mutation < /b> diminishes < /b> aggregation < /b> and < /b> stabilizes < /b> the < /b> b structure Victor ... form.Keywords: a7 < /b> nicotinic < /b> acetylcholine < /b> receptor;< /b> extracellular< /b> domains; expression in Escherichia < /b> coli;< /b> Cys116 < /b> mutation;< /b> CD spectroscopy. Nicotinic < /b> acetylcholine < /b> receptors (AChRs), belonging to the< /b> family ... studying the< /b> functional and < /b> spatial characteristics of < /b> their ligand-bindingsites. The < /b> ECD of < /b> the < /b> a7 < /b> subunit of < /b> the < /b> homo-oligomeric a7< /b> neuronal AChR appears to be a more suitable object thanthe...
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Báo cáo Y học: DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase docx
... Amsterdam, the < /b> Netherlands;2Department of < /b> Biochemistry, University of < /b> Stellenbosch, South Africa;3Section of < /b> Molecular Microbiology,Biocentrum, Technical University of < /b> Denmark, Lyngby, Denmark;4Stellenbosch ... calculated by multiplying the < /b> derivative of < /b> the < /b> ®tted curve at each point of < /b> the < /b> graph with the < /b> quotient of < /b> the< /b> respective x /y < /b> coordinates. At wild-type level of < /b> supercoiling a n elasti-city coecient ... activity. Over athousand-fold range of < /b> expression of < /b> topoisomerase I the< /b> aLk varied by no more than six linking numbers, i.e.between )3 and < /b> +3 linking numbers relative to the < /b> )13active links of < /b> the...
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Tài liệu Báo cáo Y học: The glucose-specific carrier of the Escherichia coli phosphotransferase system Synthesis of selective inhibitors and inactivation studies pptx
... Methyl 2,3-anhydro-a-D-allopyr-anoside (2a) and < /b> methyl 3,4-anhydro-a-D-galactopyrano-side ( 2b) were obtained by desilylation of < /b> 1 mmol of < /b> the< /b> 6-O-[dimethyl-(1,1,2-trimethylpropyl)silyl]-protected ... group by reaction with trityl chloride, (b) benzylation of < /b> the < /b> 2, 3, 4-OH groups, and < /b> (c) acid-catalysedremoval of < /b> the < /b> 6-O-trityl group. Oxidation of < /b> the < /b> free C-6hydroxymethylene of < /b> 4 to aldehyde ... inactivation. To the < /b> contrary, the< /b> presence of < /b> Glc slightly sensitized EIIGlcfor inactivation by the < /b> isothiocyanates 1e and < /b> 3d. On the < /b> other hand, the < /b> rate of< /b> inactivation by bromoacetyl-Glc (1a)...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... of < /b> the < /b> loop indicated by the < /b> letter a.Fig. 5. Scheme of < /b> the < /b> binuclear manganese cluster and < /b> the < /b> localization of < /b> the < /b> side-chains of < /b> Asp153 and < /b> Asn153 in the < /b> modelled structures of< /b> wild-type and < /b> ... the< /b> consequences of < /b> the < /b> Asp153fiAsn substitution, we used amodelled structure of < /b> the < /b> E. coli < /b> enzyme, constructed byusing homology-modelling techniques and < /b> the < /b> 3D structure of < /b> the < /b> binuclear form of < /b> B. caldovelox ... Engineering and < /b> Biotechnology, Habana, CubaUpon mutation < /b> of < /b> Asp153 by asparagine, the < /b> catalyticactivity of < /b> agmatinase (agmatine ureohydrolase, EC3.5.3.11) from Escherichia < /b> coli < /b> was reduced to about...
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Báo cáo Y học: Investigations into the mechanisms used by the C-terminal anchors of Escherichia coli penicillin-binding proteins 4, 5, 6 and 6b for membrane interaction ppt
... Nonethe-less, the < /b> membrane interactive mechanisms utilized by the< /b> C-terminal anchors of < /b> PBP4 and < /b> PBP 6b show differences tothose utilized by PBP5 and < /b> PBP6. Here, hydrophobicmoment-based analyses ... utilized by PBP5 and < /b> PBP6 [1,2,19,21,24].Here, we have considered the < /b> possibility that differencesbetween these anchoring mechanisms may lay in the < /b> ability of < /b> the < /b> low molecular mass PBPs to form oblique ... [18].A number of < /b> authors have used theoretical analysis toinvestigate the < /b> potential of < /b> the < /b> PBP4, PBP5, PBP6 and< /b> PBP 6b C-terminal regions for membrane interaction and< /b> based on these analyses, it...
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Báo cáo y học: " Self-reported sickness absence as a risk marker of future disability pension. Prospective findings from the DWECS/DREAM study 1990-2004"
... exposure contrast and < /b> reduce the < /b> generalizability of < /b> the < /b> results, and < /b> the < /b> findings may therefore not apply to the < /b> general population. The < /b> present study and < /b> the < /b> study by Gjesdal and < /b> Bratberg [10] ... According to the < /b> majority of < /b> the < /b> found studies, the < /b> recall period is too long, and < /b> the < /b> possibil-ity of < /b> a systematic over- or underestimation of < /b> sick-ness absence is present, most probably a systematic ... which may not always be obtainable, and < /b> mostly in countries with a welfare system providing and < /b> regis-tering compensation for absence and < /b> disability. We therefore studied the < /b> predictive abilities...
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Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
... marrow and < /b> the < /b> gastrointestinal tissues from the < /b> cytotoxicity of < /b> CY in mice. We also profiled the < /b> changes of < /b> the < /b> expression of < /b> growth factors in gastric tissues in response to the < /b> damage by CY and < /b> ... toxicity of < /b> CY on bone marrow by measuring WBC number in the < /b> peripheral blood. Twenty microliters of < /b> blood was mixed with 380μl of < /b> Randolph’s solution. WBC counting was then performed by using ... respectively) and < /b> duodenal tissues (Fig. 3A and < /b> 3B respectively). Dose-dependent effects were observed in general. Western blot analysis implicated the < /b> reduction by CY and < /b> normalization by AP of < /b> blood...
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Báo cáo y học: "Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary"
... for the < /b> Community Control of < /b> Hereditary Diseases, Budapest, Hungary Corresponding address: Andrew E. Czeizel Foundation for the < /b> Community Control of < /b> Hereditary Diseases, 1148 Budapest, Bolgárkerék ... used the < /b> term birth (live- and < /b> stillbirths) prevalence in the < /b> past. However, recently the < /b> different methods of < /b> prenatal diagnoses have been used widely for the < /b> detection of < /b> fetal defects and < /b> ... epicanthal folds, ocular hypotelorism, preauricular tags and < /b> pits, low-set ears, simian crease, clino- and < /b> camptodactyly, partial syndactyly between toes 2 and < /b> 3, hydrocele, umbilical hernia, sacral...
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Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
... 50%. The < /b> only feasible way that pre-screening might work at an acceptable level of < /b> efficiency would be to screen blastocyst-stage embryos. However, blastocyst biopsy techniques are in their ... would be an obvious choice of < /b> transgene delivery method for human embryos. The < /b> technique is well established in animals, and < /b> is likely to be directly applicable to the < /b> human zygote [6, 7, 8]. Zygotes ... could be taken from 8 cell stage embryos and < /b> analysed by PCR for the < /b> presence of < /b> transgene DNA. However, such pre-screening would not be 100% reliable, due to mosaicism within the < /b> early embryo....
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Báo cáo y học: "Update on the treatment of ocular toxoplasmosis"
... by Rothova et al was 250mg a day or 500mg every other day and < /b> therapy was associated with pyrimethamine 100mg on the < /b> first day that was fol-lowed by 50mg a day. Prophylaxy of < /b> recurrence of < /b> ... introduce a therapy were the < /b> following: a) the < /b> presence of < /b> a lesion within the < /b> vascular arcades of < /b> the < /b> posterior pole (zone 1) b) the < /b> presence of < /b> a lesion in the < /b> proximity of < /b> the < /b> optic nerve or the < /b> ... their efficacy in vivo in the < /b> treatment of < /b> toxoplamosis. To increase the < /b> efficacy of < /b> therapy a combination of < /b> sulfadiazine and < /b> pyrimethamine was proposed since synergistic effect of < /b> these two...
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