Báo cáo khoa học: "Co-evolution of Language and of the Language Acquisition Device" docx
Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
... forextracellular ligands in the pericellular environment[15] (Fig. 2). The remaining portion of the membrane-bound receptor loses its ability to bind ligands, and can be further processed by the presenilin ... hydrophobicenvironment (mainly between Leu403 and Val404) of the phospholipid bilayer of the membrane [17]. Inturn, there is decreased plasma membrane targeting of the transcriptional cofactor calcium ⁄ calmodulin-associ-ated ... How-ever, the mechanism remains unknown.Integrins and syndecans together may influence the outcome of cell adhesion and migration because theirdifferent activation states and clustering on the cellsurface...
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Báo cáo khoa học: "Determining Term Subjectivity and Term Orientation for Opinion Mining" docx
... sets Lp and Ln of known Positive and Negative terms, respectively, and expands them into the two final training setsT rp⊃ Lp and T rn⊃ Lnby adding them new sets of terms Up and Unfound ... orien-tation) is given by the sum of the weights of itssemantic association with the seed positive termsminus the sum of the weights of its semantic as-sociation with the seed negative terms. ... comparing the lengths of (i) the shortest path between t and the seed term good, and (ii) the shortest path be-tween t and the seed term bad: if the former isshorter than the latter, than t is...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... entry of fatty acid into mitochon-dria. Thus, the steady-state level of malonyl-CoA inthese tissues is determined by the relative activities of ACC and malonyl-CoA decarboxylase.Role of the ... ghrelin and adiponectin alter hypothalamic AMPK and malo-nyl-CoA levels [13,23,28,30–33]. The genetic evidencefor the role of AMPK in the hypothalamus is less clearbecause the loss of the AMPKa2 ... lipid nutrient sensing in the brain and is an example of an enzyme that can sense and respond to the nutritional environment. The majorchallenge to understanding the role of CPT1c is todetermine...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... molecule takes the position of the adenine ring of ATP. The carbon and oxygen atoms of pantoate are shown inyellow and red, respectively. The carbon and oxygen atoms of ATP are shown in red, the nitrogen ... between the O2 atom of pantoate and the Nf atom of the sidechain of Lys39. However, there are a large number of water-mediated networked interactions that stabilize the pantoate at site II. The ... from low amounts of pantoate [9]. Here, wereport the results of the structural studies of the panto-ate-bound form of the N-terminal domain of E. coliPS (nPS). The structure and substrate-binding...
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Tài liệu Báo cáo khoa học: Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion pptx
... performed and the P-values are displayed, as calculated using the Student’s t-test. The mean and standard deviations of absolute numbers of the observedcolonies are indicated. (C) Number of colonies ... were lysed and dilutions plated and cultured for 2 days at27 °C. The number of colonies for OTUB1 and the OTUB1 mutants were counted and presented relative to the number obtained for the control ... KesslerDepartment of Clinical Medicine, University of Oxford, UKIntroduction The genus Yersinia consists of three pathogenic speciesthat are agents of a variety of diseases, one of whichwas historically the...
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Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf
... 158(21) and 296(154) [14–17]. The high specific activity of theseFVIIa variants is presumably linked to a more stableburial of the N-terminus of the protease domain in the activation pocket of the ... included in the pub-lished alanine scanning mutagenesis study of FVIIa[13], and investigated the effects of the mutation on the enzymatic maturation of FVIIa and on the response of FVIIa to ... cleavage of the scissile bond. This would affect FX and peptidehydrolysis similarly, supported by the similar decreasein the rate of cleavage of both types of substrates. The effect of the G372(223)A...
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Tài liệu Báo cáo khoa học: Post-translational modifications of the linker histone variants and their association with cell mechanisms docx
... number of these modifications is low, the density of modifications is much the same as in the rest of the lin-ker histones. It is the shortness of the N-terminal tailsTable 1. Alignment of chicken, ... studies [14–16] suggest that the linkerhistone is close to the dyad axis of the core particle at the entry and exit of the DNA. Similarly, the geometry of one nucleosome in the fibre relative to a ... histonesHistorically, the location of the globular domain of the linker histone has been a matter of contention [13].Currently, although there is a good degree of agree-ment about the overall parameters of the...
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Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc
... presenting the pulse of Src activity in the plane of the inactive and active fractions, si and s1. If the duration of the stimulus exceeds the critical value, the trajectory in the (si, ... conformation, the SH2 domain binds to pYion the C-terminal tail, and the Src homology 3 (SH3) domain binds to the linkerbetween the SH2 and kinase domains at the back of the small lobe, preventing the ... by the addition of relevant phosphatases (or other Src activators, such as the SH2/SH3-ligands) [38] to activate step 1, followedby the addition of Csk and ATP to the reaction med-ium. At the...
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Tài liệu Báo cáo khoa học: Studies on structural and functional divergence among seven WhiB proteins of Mycobacterium tuberculosis H37Rv pdf
... except WhiB2, the amino acid imme-diately after the C-terminal cysteine of the CXXCmotif is proline (Fig. S6). In WhiB2 the absence of proline and therefore of the kink might not allow the protein ... conditions [15]. The rate of dis-integration was directly correlated with the duration and strength of the oxidizing environment. Similarly,in this study, the intensity of the brown color and the iron–sulfur ... at the amino acid sequence level both WhiB5 and WhiB6differ from the others, and the difference is clearlyreflected in their secondary structure. The other impor-tant point is that although the...
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Tài liệu Báo cáo khoa học: Substrate specificity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria brassicicola ppt
... resulted in 55% and 51%loss of the initial activities of BHLmL2 and BHAb,respectively. These results strongly suggest that Ser isinvolved in the catalytic activity of BHLmL2 and BHAb and are consistent ... 97% inhibition of BHLmL2 and BHAb, respectively. The influence of pH on the activities of the BHenzymes was investigated in the pH range 6–11. The pH optima were determined to be in the basic range(pH ... and BHAb. The temperature dependence of the activities of the BHs was tested in the range 5–56 °C; the apparentoptimum temperatures of BHLmL2 were 25–30 °CTable 3. Masses and scores of tryptic...
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