Báo cáo Y học: Optimizing the delivery systems of chimeric RNA DNA oligonucleotides Beyond general oligonucleotide transfer ppt

Báo cáo Y học: Optimizing the delivery systems of chimeric RNA . DNA oligonucleotides Beyond general oligonucleotide transfer ppt

... REVIEW ARTICLE Optimizing the delivery systems of chimeric RNA . DNA oligonucleotides Beyond general oligonucleotide transfer Li Liang, De-Pei Liu and Chih-Chuan LiangNational Laboratory of Medical ... with the development of delivery systems can RDOs be used for gene therapy, andsuccessfully applied to functional genomics.Keywords: chimeric RNA DNA oligonucleotides; gene delivery; gene therapy; ... ovary cells; DMRIE, dimyristyloxypropyldimethylhydroxyethylammonium bromide; DOPE, dioleoyl-phosphatidylethanolamine; DOPS, dioleoylphosphatidylserine;DOTAP, dioleoyloxypropyl trimethylammonium...

Báo cáo Y học: Monitoring the structural consequences of Phe12 ﬁ D-Phe and Leu15 ﬁ Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf

... shows the family of 40 structuresand Table 1 contains a summary of statistical data indica-ting the quality of the 40 models and the average energy-minimized structure. The polypeptide chain of ... CordopatisDepartment of Pharmacy, University of Patras, GreeceA new human/rat CRH analogue has been synthesizedusing the Fmoc/tBu solid-phase synthetic protocol. The sequence of the new peptide diﬀers from the ... preterm labour, anxiety and depres-sion and a potentially great number of other disorders.We have previously described the synthesis and the biological evaluation of a new series of CRH analogues,which...

Báo cáo Y học: Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus pptx

... occlude channels by binding to the outeropening of the conduction pore, at the centre of symmetry of the channel [2–6].Two new toxins blocking transient A-currents wererecently isolated from ... (Applied Biosystem) using a-cyano-4-hydroxycin-namic acid as matrix.Lethality assay in mice The in vivo toxicity of venoms, HPLC fractions or puriﬁedtoxins was tested in male C57 Bl/6 mice by intracerebro-ventricular ... seems to increase with the number of positivelycharged residues in the N-terminal half of these toxins (sixfor AmmTX3 and Aa1, ﬁve in BmTX3) and with the hydrophobicity of certain residues (Ile2...

Báo cáo Y học: Reconstructing the replication complex of AcMNPV pdf

... with2 lg of the reporter plasmid pCAPCAT, and either 0.5 lg of each of the clones of the overlapping AcMNPV k libraryor 1.0 lg of each plasmid of the overlapping lef library asdescribed by Passarelli ... by insertion of PCR products into the BglIIand PspAI sites of plasmid phsp70HAHisVI+ containing the 5¢ terminal amino acid sequence RYPYDVPDYARA. The sequence YPYDVPDYA constitutes the haemaggluti-nin ... into the nature of the AcMNPV DNA replication complex, we examined the ability of each taggedlef to interact with other replication lefs. This was accom-plished by employing both yeast two-hybrid...

Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"

... commonly complicated by hyperglycaemia caused by mediators of stress and inflammation. Severity of disease is the main risk factor for development of hyperglycaemia, but not all severely ill ... fortendency to hyperglycaemia that are the root of hospitalacquired hyperglycaemia and in the long term lead todevelopment of diabetes.Although the incidence of hospital acquired hypergly-caemia ... included in the early years of the study werefollowed after the targeted five-year period; maximal fol-low-up time was 11 years for patients included in the firstyear. Cumulative incidence of diabetes...

Báo cáo y học: "Facing medical care problems of victims of sexual violence in Goma/Eastern Democratic Republic of the Congo"

... assessment of the availability of key resources to treat victims of sexual vio-lence in hospitals regularly caring for victims of sexualviolence; and (3) assessment of the frequency of delivery of ... violence in the four hospitals of Goma. Only half of the hospitals had physicians specializedin gynaecology or gynaecological surgery available. Similarly, anaesthetists and psychiatrists/psychologists ... in the area of Goma, which is the capital city of the North Kivu province in the Eastern DemocraticRepublic of the Congo.MethodsThis analysis was designed as a combined retrospectivestudy...

Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"

... by use of regular reminders until the first day of the study period. The staff designated to form the MET varied between participating centers because of local circumstances. The study protocol ... criteria and who were subsequently admitted to the ICU. During the study, there were no differences in the incidence of the composite primary outcome between the control and MET hospitals (5.86 ... that early intervention may prevent further deterioration and/or death. We investigated whether implementation of a medical emergency team (MET) system could reduce the incidence of cardiac...

Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"

... the potentially limited generalizability of patterns of care in the VHA system and possible dissimilarity in the RA patients it treats compared to other RA populations. However, sensitivity ... patients and generally continued even if therapeutic response is suboptimal, in contrast to other RA therapies where the drugs are typically discontinued if they are not effective. Because of similarities ... activity measures such as the DAS28 may not adequately capture underlying RA disease activity for some patients (e.g. those with concomitant fibromyalgia). Moreover, patients may fear that they...

Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"

... the management of patients have a sound grasp of at least the basics of statistical methods. Unfortunately, in practice this isoften not true, with many relying on distant memories of poorly ... Although some of the topics covered in this serieswill probably be familiar, it is hoped that there will still be usefullessons to be learned, for example the underlying assumptions of a hypothesis ... analysis of survival data. Ideally the series will evolve to meet the needs of Critical Care readers,and you are encouraged to suggest additional topics that youwould like to see covered in the...

Báo cáo y học: "A Comparative Effectiveness Study of Bone Density Changes in Women Over 40 Following Three Bone Health Plans Containing Variations of the Same Novel Plant-sourced Calcium"

... unacceptable by the end of the study. In all three groups and sub-groups, none of the normal scores were abnormal by the end of the study. Thus, it was our conclusion that the absence of changes in the ... repeated measures of total bone density phantoms provided by the manufacturer. Outcome Measure of safety. To assess safety in all three Plans at baseline and at the end of the study period, subjects ... supplementation. These increases occurred without adverse side effects. While the study also provides evidence of the benefit of adding the physi-cal activity and health literacy components, the data...

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