Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase pptx
Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase pptx
... PAH and TH (Eur. J. Biochem. 270) 1075 Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and ... binding to the catalytic domains of PAH and THDocking of the native cosubstrate BH4 into the crystalstructure of the PAH catalytic domain yielded a total of 286 conformations. Out of these, 44 ... actualfeatures of the structural environment defining the activesite underlie the substrate specificity of PAH and TH.Rapid conversion of active cosubstrates and substrates into their products...
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Báo cáo khoa học: by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site potx
... conclusion, the present studies provide the firstsystematic and detailed characterization of the nucleotidebinding specificity of the N- and C-terminal nucleotidebinding sites of the 90-kDa molecular chaperone, ... an intact adenine ring; the stick model is the structure of the kinked ADP in the Hsp90 crystal, the phosphates pointing out of the domain;Rstandsforphosphates(ATP)orothermoietiesasinNADor adenosine ... or even the orientation (therefore the cleavage) of the iron-polyphosphate moiety might differ form that of the biologically predominant magnesium–ATP. Furthermore, the susceptibility of neighboring...
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Báo cáo khoa học: "Learning How to Conjugate the Romanian Verb. Rules for Regular and Partially Irregular Verbs" docx
... looking at the inflection of the verbs and number of allomorphs of the stem. Romalo(1968, p. 5-203) produced a list of 38 verb types,which she eventually reduced to 10.For the purpose of machine ... alternations occuring in the stem of irregular and partially irregular verbs. The system of rulespresented below took into account both the end-ings pattern and the type of stem alternation foreach ... aparticular type of verb class with a particular set of suffixes. Note that the dot accepts any letterin the Romanian alphabet and that, for each of the six forms, the value of the capturing groups(those...
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Báo cáo khoa học: Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells pot
... bioas-says specific to the extract. Pure compounds are thenisolated from active fractions and the structure of the compound is determined. The activity of the chemo-preventive agent is then confirmed ... focus on IxoA because of its abundance in the leaves and stems of the plant and its presence in the fruits.To examine the mechanism that might account for the effects of IxoA in colon cancer ... for the influence of diet oncolon cancer development [6,8,9]. Therefore, the dis-covery of novel chemopreventive agents of natural origin has been targeted, with fruits and vegetablesbeing of...
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Tài liệu Báo cáo khoa học: S100–annexin complexes – biology of conditional association doc
... S100–annexin complexes have a role in the differentiation of gonad cells and neurological disor-ders, such as depression. These complexes regulate the organization of membranes and vesicles, and thereby ... Ca2+via EF-hand motifs and undergo large conformationalchanges. These changes induce the exposure of ahydrophobic patch at the surface of these molecules and assist them to interact with their target ... be caused by the loss of the S100A10–annexin A2 complex on the outer surface of the plasma membrane of the endothelial cells.S100A11–annexin A1 complexDistribution The association of S100A11...
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Tài liệu Báo cáo khoa học: S100–annexin complexes – structural insights pptx
... that the acetyl group aidsin the stabilization of the helix dipole of the annexinN-terminus, and therefore the required helical confor-mation of the peptide. The rmsd for the backbones for the ... each of the hydrophobic residues are labelled. For example, the side-chain of L7 of annexin A1 is within 6 A˚ of the side-chains of L45, A47, F48 within the linker of S100A11, L85 and C89 of helix ... shows the direc-tion of movement), exposing a hydrophobic cleft between helix IV and the linker of one monomer and helix I¢ of the other monomer. (C)Binding of the N-terminal region of annexin...
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Báo cáo khoa học: A single mismatch in the DNA induces enhanced aggregation of MutS Hydrodynamic analyses of the protein-DNA complexes pot
... either ‘Regularization’ or DynaLS analysis of the entireset (¼ 10) of curves. The goodness of the fit by DynaLSsoftware was evaluated by visual inspection of residualdistribution (random and ... obviates the need of looping of interveningDNA. The in vivo data supporting the MutS–MutLfoci formation suggests the possibility of extensiverecruitment of protein molecules at the sites of mis-match ... function of time. The width of distribution of Rhwas in the range of % 50 nm in these samples. Next,two higher concentrations of ATP (1 mm and 10 mm)brought about rapid aggregation of MutS,...
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Báo cáo khoa học: Data-driven docking for the study of biomolecular complexes pptx
... partly depends on the kind of data used (e.g. the level of detail and the amount of inherent ambiguity) and the samplingmethod. ‘Geometric’ methods might limit the number of orientations selected ... microscopy and tomography can also provide valuable information about the ‘shape’ and organiza-tion of biomolecular complexes. As these are ratherdifferent kinds of approaches, we will not review themhere, ... assessment of which residues of the labeled molecule are perturbed by the formation of the complex. One then repeats this procedure with the second molecule labeled. Under the assumption that the perturbed...
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Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc
... all-trans retinol(atROL) as the substrate for the conversion of 11cROL [24–27]; the substrate of RPE65 in the RPE isatRE [12]. To verify the substrate specificity of zebra-fish RPE65c, total ... the area of the 11cROL and 13cROL peaks and expressed as the mean ± SD of three independent measurements.Retinal cell dissociation The zebrafish eyes were enucleated, and the corneas and lenswere ... (ortho-logue of human RPE65) and retains all of the known key residues for the enzymatic activity of RPE65. Similar to the other RPE-specific RPE65,RPE65c was present in both the membrane and cytosolic...
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Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc
... stefin A and the different enzymes is the averagedistance between the centre of mass of CA atoms of the stefin molecule and the centre of mass of the CA atoms of the reactive site cysteine and histidine ... its original position. A comparison of the structure of the unli-ganded cathepsin B with the structure of the proenzyme, its complexes withchagasin and stefin A shows that the magnitude of the ... nor the inhibition of the enzyme by their endoge-nous protein inhibitors cystatins and stefins [21].A further step in understanding of these mechanisms was provided by the crystal structures of...
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