Báo cáo khoa học: The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest pdf
Báo cáo khoa học: The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest pdf
... levels of regula-tion: the synthesis of the cyclins and their assembly intocyclin/Cdk complexes [14], the phosphorylation of the Cdks, and the inhibitory action of the Cdk inhibitors (CKIs) in these ... Rat1 /ras cells at the G1 phase of the cell cycle, following up-regulation of the cell cycle inhibitorp27Kip1 and down-regulation of the kinase activity of the cyclin E/cyclin-dependent kinase-2 ... Cell growth of Rat1 /ras cells was arrested at the G1 phase of the cell cycle. Analysis of cell cycle components showed thatHR12 treatment of Rat1 /ras cells led to elevated cellularlevels of the cyclin-dependent...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... in nontransfected, Scramble- and ANT1 and ANT2 siRNA-transfected cells. (D) Westernblot analysis of ANT protein in Scramble- and ANT1 and ANT2 siRNA-transfectedcells; the 33 kDa band corresponds to ... ANT1 and ANT2 transcripts in nontransfected ADF cells. (B) Number of ANT1 transcripts in nontransfected, Scram-ble- and ANT1 and ANT2 siRNA-transfectedcells. (C) Number of ANT2 transcripts in nontransfected, ... informationabout the function of ANT proteins in the regulation of cell death⁄ survival processes. We analyzed the role of ANT1 and ANT2 isoforms in a human glioblas-toma cell line, the ADF cells in which,...
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Tài liệu Báo cáo khoa học: "The Structure of User-Adviser Dialogues: Is there Method in their Madness?" pdf
... focusing, topic shifts, the use of pronominal noun phrases to refer to antecedents in focus, and the use of non-pronominal noun phrases to refer to antecedents not in focus. 224 Gross and ... independent converging analyses: a) the distribution of non- pronominal and pronominal noun phrases b) the distribution of antecedents of pronominal and non-pronominal anaphors, and c) the ... positioned in N and N-1. Their distribution is consistent with the derived dialogue structure on the basis of an analysis of the task and an analysis of the users' and adviser's plans and...
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Báo cáo khoa học: The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXa reductase and human biliverdin-IXb reductase potx
... BVR-B and BVR-A is likely to involve the B-face hydrogenatom attached to C4 of the nicotinamide ring and the two bridging pyrroles (rings B and C) with the linkingC10 methene bridge as the electrophilic ... inhibitors of BVR-A.With this in mind, and in the absence of a crystalstructure of the ternary complex of BVR-A with pyri-dine nucleotide and biliverdin, we set out to furtherprobe the nature of ... provesignificant during organ transplantation by elevating the concentration of cytosolic biliverdin-IXa. The pau-city of information on the biliverdin binding site hashampered the development of inhibitors...
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Báo cáo khoa học: The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology pptx
... coexpression of angiotensin I and bradykinin B2receptors in HEK-293cells increases the efficacy and potency of angiotensinII, but it also reduces the ability of bradykinin to sti-mulate inositol phosphate ... GPCR–b-arres-tin interaction. (A) The sequential binding of the ligands to each half of the receptordimer induces the recruitment of twomolecules of b-arrestin and then the activation of ERK. (B) ... a mutant muscarinic M3receptorthat is incapable of binding to b-arrestin-1 impairscompletely the ability of wild-type M3receptors to recruit b-arrestin-1 to the plasma membrane and to stimulate...
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Báo cáo khoa học: The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics doc
... phenylanine at thisposition in the 5HT2 subfamily of serotonin receptorshas been suggested to be involved in ligand binding[87]. On the other hand, early experimental studiespointed to the involvement ... algorithms and the selection of the sequences in the alignmentdetermine the nature of the answers returned by the application of the computational tools. The statisticalnature of these tools makes their ... 50, and the N2 values of the other locidecrease towards the N-terminus and increase toward the C-terminus. The compilation of the predicted dimerization ⁄ oligo-merization interfaces obtained...
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Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt
... cargo binding sites, referred to as the major and minor binding sites [1]. These sites arelocated in the concave face of the protein near regions of invariant Trp and Asn arrays. The major bindingsite ... positioned at the end of the binding pocket. In total, the CLIC4 NLS main chain and side chainsmake 174 atom -to- atom van der Waals’ contacts withimportin-a and 13 hydrogen bonds, including one saltbridge ... affinity for cargo proteins and help-ing to facilitate the release of the cargo within the nucleus [10,11]. The removal of the autoinhibitorydomain to create a truncated importin-a avoids possi-ble...
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Tài liệu Báo cáo khoa học: The occurrence of hemocyanin in Hexapoda docx
... hex-amerins, crustacean hemocyanins, crustacean pseudohemocyanins, chelicerate hemocyanins, myriapod hemocyanins and one onychophoranhemocyanin. The onychophoran hemocyanin (EpiHc1) was used to root ... Crustacean hemocyanins and pseudohemo-cyanins form a third clade with 1.00 posterior proba-bility and 100% bootstrap support. The monophyly of crustacean and hexapod hemocyanins and hemo-cyanin-related ... also included 17 selected insect hexamerins, 23crustacean hemocyanins, 4 crustacean pseudohemocyanins,20 chelicerate hemocyanins, 5 myriapod hemocyanins and 1 onychophoran hemocyanin in the...
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
... increase the activity of aB-crystallin against DTT-induced precipi-tation of insulin at intermediate and high concentra-tions, and it also increased the activity of aB-crystallin in preventing the ... 20 min, and the increase in light scattering due to precipitation of the protein reached a maximum after 90 min (Fig. 3A).All of the additives tested increased the amount of light scattering ... thought to be determined by a number of fac-tors, including the rate of unfolding, the amino acidsequence of the protein, the experimental conditions and the nature of the intermediate state(s)...
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Tài liệu Báo cáo khoa học: The sequentiallity of nucleosomes in the 30 nm chromatin fibre pptx
... 2008)doi:10.1111/j.1742-4658.2008.06522.x The folding of eukaryotic DNA into the 30 nm fibre comprises the firstlevel of transcriptionally dormant chromatin. Understanding its structure and the processes of its folding and unfolding ... crosslinking of nucleosomes and digestion of the DNA to mononucleosome size of samples con-sisting of a mixture of hepta-, octa- and nonanucleosomes and half the amount of hexa- and decanucleosomes ... mononucleosomes and the band S. DNA gel electrophoresis of the fractionsfrom Fig. 3D,E showed that approximately 90% of the DNA in the main peak as well as the mononucleo-somes and band S are all in the...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roTăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘITÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ