Báo cáo khoa học: "Quantitative modeling of the neural representation of adjective-noun phrases to account for fMRI activation" doc

... biologically-informed model of semantic representation of lexical knowledge. We there-fore look forward to further brain imaging stud-ies shedding new light on the nature of human representation of semantic ... model. The adjective model assumes that the meaning of the composition is the same as the adjective: up= The noun model assumes that the meaning of the composition is the same as the ... found the modifier-head interpretation of the multiplicative model to best account for the neural activity ob-served in adjective-noun phrase data.Table 4 shows the semantic representation for...

Báo cáo khoa học: Quantitative modeling of triacylglycerol homeostasis in yeast – metabolic requirement for lipolysis to promote membrane lipid synthesis and cellular growth potx

... point of view, they allow the cell to dispose of excessmetabolites by storing them in an inert form. Whendemand for these metabolites is high, they are read-ily available without the need for ... supporting the predominant role of TAG to provide precursors for phospholipidsynthesis during the initiation of cellular growth.However, these simulations show that the cell is able to respond to a ... andpromotes the rapid initiation of growth of quiescentcells exposed to glucose-containing media. TAG mobi-lization provides DAG and ⁄ or FA for the synthesis of phospholipids; forcing the system to...

Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx

... in apoptosis, the relationship of these two molecules is stilllargely unknown. The aim of the current study was to investigate the potential involvement of nucleolin ⁄ C23 in the antiapoptotic ... microscopy. Apoptotic cells wereidentiﬁed by the condensation and fragmentation of theirnuclei. The percentage of apoptotic cells was calculated as the number of apoptotic cells divided by the total ... out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. All efforts were made to minimize the number of animals used and their suffering.H2O2pcDNA3.1100100...

Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf

... sites to the inhibitory regions of Akazara scallop and rabbit TnI, respectively.ATnI232)292and RTnI96)181correspond to the regionsspanning from the inhibitory regions to the C-termini of these ... [26]. The initiator Met at the N-terminus was removed by the bacterial cell for all these proteins except for RTnI96)181.Inhibition of Mg-ATPase of actomyosinby TnI-fragments The inhibition of ... that by ATnI-19K (88%) orATnI130)252. Therefore, the effects of the N- or C-ter-minal region of TnI on the function of the inhibitoryregion appeared to differ between rabbit and Akazarascallop...

Tài liệu Báo cáo khoa học: "Event Matching Using the Transitive Closure of Dependency Relations" pdf

... based on the transitive closure of the dependency relation of the event and that of the de-pendency relation of the sentence. Our aim was to achieve a balance between the speciﬁcity of depen-dency ... parse trees. The set of nonterminal labels associated with each word is the set of labels of the nodes for which that word was the head. For example, in the lexicalized tree inFigure 1, the head ... de-noting the index of the word that is the descendantin dxand dx.a denoting the ancestor. We deﬁne the following matching function to match the pair of de-scendants (or ancestors):matchd(de,...

Tài liệu Báo cáo khoa học: Dimer asymmetry and the catalytic cycle of alkaline phosphatase from Escherichia coli doc

... to the Ser102 conformation and the nature of the metal ion bound to the M3 site [10]. The APasePistructure displays anincreased mobility of the active site with pronouncedanisotropy for the ... notaffect the difference between the subunits with respect for their afﬁnity for the substrate or the product (the differenceFig. 3. The inﬂuence of Zn2+on the kinetic properties of APase fromE. ... formation of the nucleophile for the hydrolysis of the covalent inter-mediate. Alternatively, the mechanism that includes the trianion may have evolved in order to control the dissociation of the...

Báo cáo khoa học: Lipopolyamine treatment increases the efﬁcacy of intoxication with saporin and an anticancer saporin conjugate doc

... into the endosome membrane,which permits passage of the toxin catalytic subunitinto the cytosol. A second category of AB toxins trav-els from the endosomes to the Golgi apparatus enroute to ... of the newly synthesized chimeric toxin mislocalized into the cytosol. Most toxins that reach the ER exploit the quality control system of ER-associated degradation(ERAD) for translocation to ... site for dimethylsulfoxide-facilitatedentry of saporin into the cytosol. The LEX2 inhibition of cargo delivery to the late endosomes would therebyincrease the pool of saporin available for passage...

Báo cáo khoa học: Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding pdf

... certain protein substratesBefore testing the unfolding activity of RR ⁄ AA, wewished to compare the ability of the RR ⁄ AA mutant to bind to the various substrates tested. To do this, weconstructed ... initiatedthrough productive binding to the substrate via twoelements in ClpA, one in the N-domain and the otherin the pore of the ClpA hexamer. In the case of shortunstructured peptides or unfolded ... from the rapid exchange of 80 accessibleamide protons. In the absence of ClpA, the remainingamide protons within the protected core did notexchange over a period of 2 h (data not shown). In the Fig....

Báo cáo khoa học: "Some Problems in the Mechanical Translation of German" pdf

... its form excludes the possibility of it being nominative, then the relative pronoun may be taken to be the subject of the clause. This ap- plies to about half of all the instances where the ... preference being given to the formally distinct denen. The presence of a preposition, on the other hand, does not solve the problem as before, unless the preposition is of the type which can be ... a subordinate clause the verb must normally come at the end. How, then, are we to deter- mine the function of the relative pronoun in those instances where the form of the relative provides...

Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx

... contributes to maintaining the conformationalswitch of the V1aR in the off-state. The unique ability of arginyl to fulﬁl this constraining function in the N-terminus of the V1aR is similar to the ... ([Ile8]oxytocin) are the evolutionary precursors of oxytocin [1]. The receptors that mediate the effects of thesehormones are G-protein coupled receptors (GPCRs) andinclude the isotocin receptor, the ... mesotocin receptor, the oxytocin receptor (OTR), the vasotocin receptor and threesubtypes of vasopressin receptor: V1a,V1band V2(V1aR,V1bRandV2R respectively). In addition to the...

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