Báo cáo khoa học: Molecular basis for substrate recognition and drug ˚ resistance from 1 1 to 1 6 A resolution crystal structures of HIV-1 protease mutants with substrate analogs pptx
... Shimura Y, Ibuka A, Sakai H,
Matsuzawa H, Sakano Y & Ohta T (19 95) Comparison
of primary structures and substrate specificities of two
pullulan-hydrolyzing a- amylases, TVA I and TVA II,
from ... (2002) Crystal structures and structural com-
parison of Thermoactinomyces vulgaris R-47 a- amylase I
(TVAI) at 1. 6 A
˚
resolution and a- amylase II (TVAII...
... P2
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Beamline X 11 X 11 X 11 X 11 X 11 ID14 -1
Unit cell:
a ¼ 56. 86 A
˚
56. 73 A
˚
57.28 A
˚
56. 80 A
˚
56. 71 A
˚
56. 78 A
˚
b ¼ 83. 21 A
˚
83. 36 A
˚
82 .68 A
˚
83 .14 A
˚
83.59 A
˚
83.32 A
˚
c ......
... et al.
2 762 FEBS Journal 278 (2 011 ) 2753–2 766 ª 2 011 The Authors Journal compilation ª 2 011 FEBS
catalytic base, and the 17 -fold drop in k
cat
for the
Y 118 F mutant implicates Tyr 118 as a catalytic ... lyase pathway). Bottom: cleavage to
yield AMPA and glyoxylate (the AMPA
pathway), referred to as the GOX pathway.
(B) Reaction catalyzed by GO on glyphosate,
an alternativ...
... Al Karadaghi S (20 01) Interplay between
an AAA module and an integrin I domain may regulate
the function of magnesium chelatase. J Mol Biol 311 ,
11 1 12 2.
7 Reid JD, Siebert CA, Bullough PA & ... a higher
available concentration of ChlM to bind other mole-
cular species in the reaction.
ChlH appears to enhance catalysis by accelerating
the formation and decay of a ca...
... hypophosphatasia
[1 4]. Perinatal and infantile forms of hypophosphata-
sia are severe and are usually transmitted as a recessive
trait, whereas the other three forms of hypophosphata-
sia are mild and are ... revised 18
January 2008, accepted 19 March 2008)
doi :10 .11 11/ j .17 42- 465 8.2008. 06 414 .x
Hypophosphatasia, a congenital metabolic disease related to the tis...