Báo cáo khoa học: Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium’s susceptibility to antibiotics that target the cell wall potx
Báo cáo khoa học: Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium’s susceptibility to antibiotics that target the cell wall potx
... 2005 FEBS 3003 Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium’s susceptibility to antibiotics that target the cell wall Juergen J. ... inhibitor. To test if the inhibitor 5 was able to penetrate the cell wall to reach its target DltA, we investigated chan-ges in the growth rates of the Gram positive wildtype strains B. subtilis ... 5).Discussion The biosynthesis of d-alanyl-lipoteichoic acid requiresfour proteins that are encoded by the dlt operon [5]. The synthesis starts with the selection of the d-Alaby the 57 kDa d-Ala-d-Ala carrier...
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Báo cáo khoa học: Characterization of L-aspartate oxidase and quinolinate synthase from Bacillus subtilis potx
... folding of the protein, or a charged residueclose to the [Fe–S] center that has a pKaclose to that of the sample at pH 8 so that it is only charged in afraction of the samples (about 50%). The ... suggesting that the integrity of the [Fe–S] cluster is important for the binding of iminoaspartate to NadA.ConclusionsIn the past few years there has been a revival of inter-est in the study of the ... affectde novo synthesis. In contrast, if the cysteine to serine substi-tution affected de novo synthesis, we observed that from 50% to 100% (in the case of gene conversion) of the clones that were...
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Báo cáo khoa học: Inhibition of Hsp90 function delays and impairs recovery from heat shock ppt
... health. The accumulation of a threshold level of Hsp70 sig-nals the cessation of Hsp mRNA transcription and the restoration of the normal rate of protein synthesis.This has been termed ‘autoregulation’ ... Brilliant Blue staining of the gels after electrophoresis). Labeled proteins were detected by autoradiography. The basic region of the gel is to the right, the acidic end to the left. Cells labeled after ... shock response in the absence of heat shock, as reportedpreviously. Pretreatment of cells with the Hsp90 inhibitors significantlydelayed the rate of restoration of normal protein synthesis following...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... operating at varioussteps in the cytotoxic activity of the drug, from adecrease of drug accumulation in the cell to abrogation of apoptosis induced by the chemical substance. Oftenseveral different ... determining the sensitivity of tumor cells to chemo-therapy and is linked to activation of the phosphatidylinositol-3-kinase/Akt(PI3K/Akt) pathway. In the present study, we further investigate the ... exhibiting IR; 3, 50–75% of the tumor cells exhibiting IR; 4, > 75% of the tumor cellsexhibiting IR. The overall score was the multiplication of the two. The scores were then classified as negative...
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Báo cáo khoa học: ` Inhibition of human ether a go-go potassium channels by 2+ Ca ⁄calmodulin binding to the cytosolic N- and C-termini potx
... interactionthen results in opening of these channels [9,10]. The mechanism of CaM-mediated closure of hEAG1channels is far from understood mainly because of the lack of structural information on the ... weassured that addition of 1 lm CaM to the Ca2+-containingbuffer did not alter the concentration of free Ca2+ions.For application of His-tagged hCaM, the purified protein was transferred to the ... Binding of MCGS-(H)6-hCaM to fusion proteins of cytosolic hEAG1 domains. Dissociation constants KDfor binding of TMR-MCGS-(H)6-hCaM to the indicated constructs in the absence and presence of...
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Báo cáo khoa học: Inhibition of the NF-jB transcriptional activity by protein kinase A pot
... F). These data indicate that elevation of intracellular cAMP and subsequent activation of PKA lead to the inhibition of NF-jB activity. To further examine the effect of PKA on NF-jB activity,we ... commonfeature of the regulation of the NF-jB family is theirsequestration in the cytoplasm as inactive complexes with aclass of inhibitory molecules known as IjBs [1–4]. Treat-ment of cells with ... reverse the PKA-mediated inhibition of p65 transactivation. Thus, the inhibitory action of the cAMP/PKA pathway on the transcriptional activity of NF-jB appears to be exhibited by modifying the C-terminaltransactivation...
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Báo cáo khoa học: Inhibition of the mitochondrial calcium uniporter by the oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart docx
... suggest that the cytosolic calcium concentration ([Ca2+]c) regulatesboth the utilization of ATP in the contractile process,as well as the mitochondrial production of ATP, byincreasing the mitochondrial ... much103Ru360com-pared to the enriched mitochondrial fraction (2.3 ±0.6 pmol of 103Ru360Æmg)1 of protein vs. 1.2 ±0.15 pmol103Ru360Æmg)1 of protein; n ¼ 4). The purity of these fractions ... ª 2005 FEBS 3483contradictory finding that CsA, the most potent inhib-itor of mPTP opening in isolated mitochondria, isunable to prevent the entry into mitochondria of 2-de-oxy[3H]glucose...
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Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration pot
... afterremoval of excess DA, the DA-modified protein (mixture of monomer and oligomer), also retains the cytotoxicity, supporting the hypothesis that the cyto-toxicity primarily arises from the reaction ... or dimers. The DA quinoprotein retains the same cytotoxicity as the intact a-Syn, suggest-ing that the oligomeric intermediates are the major elements that are toxic to the neuronal cells. This ... worthy of identifying the three to four reactive Lys residues in a-Syn.DA linkage retains the cytotoxicity of a-Syn The previous studies have shown that a-Syn fibrilliza-tion is toxic to neural cells...
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Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx
... inhibitors of methionine synthase. Our results indicate that the potency of the tested compounds is related to a planar region of the inhibitor that can be positioned in the centre of the active ... enzyme. The anaesthetic gas N2O is possibly the only selective inhibitor of MetS reported to date, itsaction mediated through the oxidation of the cobala-min cofactor [12]. Other compounds that ... displace the dimethylbenzimidaz-ole side chain of the cobalamin-cofactor or that it mayact on the binding site of the MetS allosteric cofactor,S-AdoMet, both effects which could explain the observed...
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... in the separ-ation of the daughter cells at the end of cell divisionand in cellular autolysis [9], where it mediates the release of toxins that damage the host tissues andallows the entry of ... inhibit the attach-ment of the CBPs to the cell wall at lower concen-trations may allow the development of newantimicrobial therapies [27] to address the problem of the increasing rates of drug-resistant ... pointed out that the fluorescence intensi-ties of the bicyclic ligands themselves are negligiblecompared to that of the protein, despite the presence of aromatic moieties, and that the use of an excitationwavelength...
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