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Báo cáo khoa học: PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AM pptx

Báo cáo khoa học: PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AM pptx

Báo cáo khoa học: PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AM pptx

... 2005 FEBS 2759 PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMPLiang Chen1,2, Peixiang Wang1,2, Cristiano F. Andrade1,2, Ian ... in the GLUTag cell line at 1, 2, 3, and 4 h.To investigate whether the activation of Cdx-2 pro-tein expression by forskolin ⁄ IBMX is caused by increasing intracellular levels of cAMP, the cell ... wefurther investigated the involvement of PKA in Cdx-2 expression. First, we compared the effects of PKAccotransfection on the expression of the Cdx-2 promo-ter vs. the proglucagon gene promoter....
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Báo cáo khoa học: Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production ppt

Báo cáo khoa học: Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production ppt

... response, and further characterization of the JNK functionlinked to gene expression downstream of Fas will helpus understand the role of the Fas-FasL system ininflammation and ⁄ or tumorigenesis.It ... 2377 the FasL- and PMA-induced activation of the minimalessential promoter of the IL8 gene (Fig. 1C). More-over, the IL-8 production induced by FasL stimulationwas reduced by the expression of ... to induce AP-1 activation. On the other hand, further deletion of Fas up to part of the DD (FD7 and FD2) or the lpr complementinggeneralized lymphoproliferative disease (lprcg) -type point mutation...
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Báo cáo khoa học: Metabolomics, modelling and machine learning in systems biology – towards an understanding of the languages of cells potx

Báo cáo khoa học: Metabolomics, modelling and machine learning in systems biology – towards an understanding of the languages of cells potx

... of the crosstalk problem, leads to a profound reassessment of howto understand the downstream effects of dynamic changes in the concentra-tions of elements in these pathways, and stresses the ... between the worlds of ideas and of experimental data. The world of ideasincludes theories, hypotheses, human knowledge and any othermental constructs, while the world of data consists of experimentalobservations ... over the timings and amplitudes of the oscilla-tions in the nuclear NF-jB concentration [18], that the nonlinearity of the model implied: (a) both a differen-tial control of the frequency and amplitude...
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Báo cáo khoa học: Puroindoline-a and a1-purothionin form ion channels in giant liposomes but exert different toxic actions on murine cells pptx

Báo cáo khoa học: Puroindoline-a and a1-purothionin form ion channels in giant liposomes but exert different toxic actions on murine cells pptx

... and the effects were quantified using the samecells examined before and during the action of the proteins. The 3D projected area of cells was measuredas an index of cell volume. The addition of ... trace), the reduction and complete block of averagedMEPPs induced by a1-PTH (B, right trace), and the absence of effect of PIN-a on the amplitude of averaged MEPPs (C, righttrace). Note the different ... indicate the relative projected area of the cells as a funct-ion of PIN-a concentration and time of exposure. (C) Immunostain-ing of actin under control conditions (Ca) and after exposure of the cells...
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Báo cáo khoa học: "Paragraph-, word-, and coherence-based approaches to sentence ranking: A comparison of algorithm and human performance" ppt

... cf. Luhn (1958)). Then, the weight of each cluster is calculated by dividing the square of the number of significant words in the cluster by the total number of words in the cluster. Sentences ... Satellite (Marcu (2000)). The Nucleus is the equivalent of the arc destination, and the Satellite is the equivalent of the arc origin in the non-tree-based approach. The symmetrical or undirected ... PRn is the PageRank of the current sentence, PRn-1 is the PageRank of the sentence that relates to sentence n, on-1 is the out-degree of sentence n-1, and α is a damping parameter that...
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Báo cáo khoa học: Bovine tryptases cDNA cloning, tissue specific expression and characterization of the lung isoform ppt

Báo cáo khoa học: Bovine tryptases cDNA cloning, tissue specific expression and characterization of the lung isoform ppt

... at the bottom of the pocket and aconsequent weaker interaction of substrates when comparedwith BLT and the other tryptases. The usual substratespecificity of BLCT was explained by assuming someconformational ... Barra,D. & Ascoli, F. (1996) cDNA cloning and primary structure of tryptase from bovine mast cells, and evidence for the expression of bovine pancreatic trypsin inhibitor mRNA in the same cells. ... K. & Hellman, L. (1993) Expression of amast cell tryptase in the human monocytic cell lines U-937 and Mono Mac 6. Scand. J. Immunol. 38, 359–367.Ó FEBS 2003 Tissue -specific expression of...
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Báo cáo khoa học: Functional characterization and Me2+ ion specificity of a Ca2+–citrate transporter from Enterococcus faecalis1 pdf

Báo cáo khoa học: Functional characterization and Me2+ ion specificity of a Ca2+–citrate transporter from Enterococcus faecalis1 pdf

... genomes of E. faecalis and S. mutansare similar, but not the same. Upstream of the citDEFgenes coding for the a, b and c subunits of citrate lyaseare the oadDB genes coding for the d and b subunitsCa ... and of proline by all membranes in the presence of Cu2+must be at the level of the transport-ers themselves. The lack of transport activity of the proline transporter in the presence of Cu2+is ... transcribed genes coding for the putative citrate transporter. The citrate lyase accessory gene citX and the oadA gene coding for the a subunit of the decarboxylase are located downstream of the cit-rate...
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Báo cáo khoa học: Photodynamic treatment and H2O2-induced oxidative stress result in different patterns of cellular protein oxidation ppt

Báo cáo khoa học: Photodynamic treatment and H2O2-induced oxidative stress result in different patterns of cellular protein oxidation ppt

... of tumor cells with photodynamictreatment (PDT). The mode of cell death by PDT may beeither apoptosis or necrosis, depending on the nature and concentration of the photosensitizer and the amount ... from the site of their generation[2]. In this way, the intracellular localization of the photosensitizer determines the areas of its photodynamicaction. Molecular targets of oxidation may therefore ... assessment of the general changes of the proteinmap on PDT was beyond the scope of this study. Under the conditions of the experiment presented in Fig. 4, the proteinmap did not change dramatically,...
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Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf

Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf

... dissociation of these twoproteins inhibits the antiapoptotic activity of Bcl-2 by initiating the release of cytochrome c from mitochon-dria into the cytosol and increasing the activities of caspase 3 and ... overall fate of the cell [10]. Insome cellular settings, autophagy can serve as a cell survival pathway to suppress apoptosis [11]. On the other hand, autophagy can lead to cell death, either incollaboration ... 2010)doi:10.1111/j.1742-4658.2010.07965.xAutophagy and apoptosis play important roles in the development, cellularhomeostasis and, especially, oncogenesis of mammals. They may be trig-gered by common upstream signals, resulting...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx

Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx

... toreduce the photosynthetic rate by decreasing the effi-ciency of the photosystem II [4–6] and ⁄ or by causingdamage to the Calvin cycle [50,51]. Moreover, in situdegeneration of zooxanthellae ... as nematodes and flies [44]. This could be explained by the basalposition of cnidarians on the metazoan tree and by the extensive gene loss in protostomes.Caspase-like activity and thermal stressAfter ... embryogenesis, to remove damaged cells, protectagainst pathogen infection, and regulate cell numbers and tissue homeostasis. Program cell death is character-istic of all multicellular animals and...
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