... 5322–5323.32 Brandon EF, Sparidans RW, Meijerman I, Manzan-ares I, Beijnen JH & Schellens JH (2004) In vitro char-acterization of the biotransformation of thiocoraline, anovel marine anti-cancer ... can be either branched-cyclic,as in the case of the last-line antibiotic daptomycin, orclosed, as in the case of the antibiotic tyrocidine A[12,13]. The nature of the intramolecular bond forma-tion ... capable of catalyz-ing ligation and the subsequent cyclization of tetrapeptidyl-thioestersubstrates, circumventing the demanding synthesis of octapeptidyl sub-strates. The general importance of...