Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated doc
Báo cáo khoa học: The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated doc
... results. Interestingly, these truncated proteins are O-GlcNAc modified in their C-terminal tail (residues670–7 11) and not in the DNA-binding domain, as for t hefull-length proteins. Thus, the O-GlcNAc ... 670–7 11) and not in the DNA-binding domain (Fig. 6). These resultsprovide another convincing example highlighting the ABFig. 7. The glycosylated t runcated forms of HIC1 a re unable to bind their specific ... dentified the SPT sequence (aminoABFig. 4. O-GlcNAc modification of full-length HIC1 proteins is predominantly localized in the DNA-binding domain. (A) Diagram of the HIC1 deletion mutants used in the...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
... DP9-overexpressing cells of the ECM-interacting molecules discoidin domain receptor1, a kinase activated by collagen binding, and the MMP inhibitor, tissue inhibitor of matrix metallopro-teinase-2, ... fordifferent cancers. Further understanding of the biologi-cal anti-invasive effect of DPIV in vitro could be ofimportance in the control of certain carcinomas.FAP distribution The unique tissue distribution ... domain and a C-terminal a ⁄ b-hydrolase domain. The a ⁄ b-hydrolase domain, containing the catalytictriad, is highly conserved throughout this protein fam-ily. The b-propeller domain, which is...
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
... [45,46].SDS–PAGE analysis of the purified proteins indicated thatthey contained < 5% contaminating proteins. The concen-trations of proteins used in these studies were determinedby spectrophotometric ... stackinginteractions of arginine and aromatic side-chains in proteins. J Mol Biol 235, 709–717.43 Lindner RA, Treweek TM & Carver JA (20 01) The molecular chaperone a-crystallin is in kinetic ... HE is supported by an NHMRC Peter Doherty postdoctoraltraining fellowship.References1 Uversky VN (2003) Protein folding revisited. A poly-peptide chain at the folding–misfolding–nonfoldingcross-roads:...
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... keep the mass cen-tre of the protein (marked with a black dot in Fig. 4) onto the axis z, and (b) to conserve the minimal distancebetween protein and membrane at 3.5 A˚. The EIE, i.e., the ... proteins, with highisoelectric point values. Thus we investigated the effectsTable 1. Natural and engineered RNases investigated in this study. IC50 is the RNase concentration producing half-maximal ... ‘r’) and variation of the inclination (inclination angle ‘i’) withrespect to the plane of the membrane (parallel to the xy plane).Cter and Nter are the C-terminal and N-terminal structural regions,respectively,...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... N-linked oligosaccharide side-chainsare important for the GABA transport activity.1-Deoxymannojirimycin inhibits the GABA-uptakeof GAT1 In order to gain further insight into the role of the terminal ... for the stability of this protein,but the terminal structure of the N-glycans is not.Defective N-glycosylation reduces the traffickingof GAT1 to the plasma membrane In order to study the in uence ... slowed kinetics of the transport cycle. This indicates thatN-glycans, in particular their terminal trimming, are important for the GABA-uptake activity of GAT1. They play a regulatory role in the...
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Tài liệu Báo cáo khoa học: "The Sentimental Factor: Improving Review Classification via Human-Provided Information" docx
... produc-ing information about the opinions that a documentcontains; for instance, Morinaga et al. (2002). In March, 2004, the American Association for Artifi-cial Intelligence held a symposium in this ... class: linear estimates for the logit.This understanding facilitates further extensions, in particular, utilizing the following:1. Labeled documents2. More anchor words The reason for using labeled ... 95120-6099AbstractSentiment classification is the task of labeling a re-view document according to the polarity of its pre-vailing opinion (favorable or unfavorable). In ap-proaching this problem, a model builder...
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Tài liệu Báo cáo khoa học: The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase doc
... accomplish the selectivecharge–charge interaction. The presence of an additionalhistidine residue in the prolyl 4-hydroxylase binding sitemay be required to maintain the lysine side-chain in apositively ... 2-OG. The difference in the levels of coupling between 2-OG andpenicillin G or ampicillin oxidation is probably a reflected in the apparent Kmvalues for these substrates. The interpretation of these ... because the presence of a positive charge in the active site would be expected to suppress cosubstratebinding. In the case of the R258K mutant this may beallowed because of disordering of the lysine...
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Tài liệu Báo cáo khoa học: "THE REPRESENTATION OF INCONSISTENT INFORMATION IN A DYNAMIC MODEL-THEORETIC SEMANTICS" ppt
... in the table using the ~-expression, and then finding the corresponding element in the model. If the element in the model that was the denotation of the h-expression was not expanded in the ... Mechanisms are introduced to eliminate these local (temporary) inconsistencies, but the most natural mechanism can introduce permanent inconsistencies in the information contained in the dynamic ... differ is several interesting ways. The difference discussed here is the possibility of inconsistent information being included in the model. If a computation causes the model to expand, the...
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Tài liệu Báo cáo khoa học: "THE INTERPRETATIONOF TENSE AND ASPECT IN ENGLISH" potx
... necessary; in this case, it is precisely the end point of the building event that coincides with the beginning of the event of the house being new. In a system using Allen's primitives, the ... tion that the cake is warm while John is frosting it, the time span during which the cake is warm must include the time 3:00; however, the starting and ending points of the cake-frosting event ... house." The building event can be thought of as beginning before the event of the house's being new. At the start of the building event, there is no house, nor, obviously, is there is any...
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Tài liệu Báo cáo khoa học: "The Use of Shared Forests in Tree Adjoining Grammar Parsing" pptx
... BLSa' ] is the distinguished child of ALSa ]. Given a derivation, the distinguished de- scendant relation is the reflexive, transitive closure of the distinguished child relation. The language ... node. In 7 t the nodes contributed by/3 have the same constraints as those associated with the corresponding nodes in/ 3. The remaining nodes in 7 ~ have the constraints of the corresponding ... of representing the parse forest one of which involves the use of linear indexed grammars and the other the use of context-free gram- mars. The work presented in this paper is intended to...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ