... Mutational analyses have
also been valuable in elucidating factors important for
activity. Table 2 lists the most informative mutations that
have been made in a range of a- conotoxins. In addition,
an ... University of Queensland, Brisbane, QLD, Australia
a- Conotoxins that target the neuronal nicotinic acetylcho-
line receptor have a range of potential therapeutic applica-...
... mature fowlicidin-1, a
linear peptide of 26 amino acid residues, was found to
be broadly active against a range of Gram-negative
and Gram-positive bacteria with a potency similar to
that of SMAP-29 ... 2534–2539.
40 Tossi A, Scocchi M, Skerlavaj B & Gennaro R (1994)
Identification and characterization of a primary antibac-
terial domain in CAP18, a lipopolysacchari...
... Golgi apparatus.
During this process, the external tubule is assembled at
the apical end of the capsule and in a later stage invag-
inates into the capsule matrix and spines are assembled
in the ... mm NaCl. SDS ⁄ PAGE in the absence of a
reducing agent showed that the spinalin of the first
peak migrates as a double band in the gel, with one
band running at a similar posi...
... route of functional diversification of
proteins via varying their conformational states and associated ligands.
Abbreviations
ANS, 8-anilinonaphthalene-1-sulfonic acid; BAMLET, bovine a- lactalbumin ... that a- lactalbumin in the MAL fraction was
structurally modified. As no post-translational modifi-
cations were detected, the folding state of a- lactalbu-
min in MAL was examined w...
... Evans. 2001. Applying machine learning: toward
an automatic classification of it. Literary and Lin-
guistic Computing, 16(1):45–57.
A. Ferr
´
andez and J. Peral. 2000. A computational ap-
proach ... Computational Linguistics
(COLING-02), pages 1–7.
Real Academia Espa
˜
nola. 2001. Diccionario de la
lengua espa
˜
nola. Espasa-Calpe, Madrid, 22 edi-
tion.
Real Academia Espa
˜
nola. 2009. Nu...
... If a similar mechanism operates in
mammalian cells, then KDM 2A may suppress this
pathway and maintain histone acetylation at tran-
scribed CG islands.
It is becoming increasingly likely that ... binding
sites accessible [204].
CG islands maintain active chromatin domains
free of DNA methylation
DNA methylation is one of the most prevalent mecha-
nisms employed within the genome to m...
... 5349
by following the changes in the 695 nm absorbance
band. It appears clear that both anions favor protein
collapse into a compact form, and induce formation of
a consistent population of macromolecules ... the K88E mutation introduces an acidic resi-
due (E88, present in yeast [28]) in place of a lysine,
whereas in site 2, the K13N mutation introduces an
asparagine in...
... protein family includes
saposins, which are lysosomal sphingolipid-activator pro-
teins [37], NK-lysin, granulysin, surfactant protein B,
amoebapores and domains of acid sphingomyelinase and
acyloxyacyl ... hydrophobic
N-terminal signal sequence, responsible for translocation
into the ER, followed by a prosegment of about 40 amino
acids, and a N-terminal domain and a C-terminal doma...
... The tandem KH1–KH2 domains of NusA recognize
RNA ligand 5¢-GAACUCAAUAG. (A) The KH1–KH2 domains of NusA bound to cognate RNA ligand (Protein Data Bank entry 2ASB). The
RNA–protein contact surface ... UACUAAC in pre-mRNA transcripts
[35], with KH domain binding augmented by addi-
tional interactions with an N-terminal helix known as
the QUA2 domain (labeled in Fig. 7) [36]. The RNA
ado...
... lyase (BAL) catalyzes cleavage and formation
of R-benzoin. BAL is known to accept several other substituted aro-
matic or aliphatic acyl-acceptors as substrates for the formation of
an acyloin ... flanked by a varying
number of a- helices. Residues involved in binding of
the cofactor ThDP are located at the C-terminal ends
of the b-strands of Dom-c (diphosphates and Mg
2+
)
an...