... Because of the poor description of the methods used in the patent and the lack of any descrip-tion of the compound synthesized, it is difficult to drawa conclusion concerning the reasons for our failure ... The discovery of two natural thiamine adenine compoundsfurther highlights the complexity and diversity of thiamine biochemistry,which is not restricted to the cofactor role of thiamine diphosphate.AbbreviationsAThDP, ... glutami-cum) are able to synthesize AThDP in the presence of suitable precursors (thiamine, ThMP, adenine, adeno-sine) added to the medium. Under these conditions, the inventors reported that the bacteria...