Báo cáo khoa học: Molecular basis of cerebral neurodegeneration in prion diseases pdf
Báo cáo khoa học: Molecular basis of cerebral neurodegeneration in prion diseases pdf
... cellular isoform of the prion protein is a key medi-ator in prion pathology. Transgenic models were instrumental in dissectingpropagation of prions, disease-associated isoforms of prion protein andamyloid ... isoform of prion protein is not exactly known,the impact of gain of toxic function or loss of function, or a combination of both, in prion pathology is still controversial. There is increasing ... an interac-tion of PrPCwith accessory proteins, such as trans-membrane proteins involved in PrP-induced signaling.Alternatively, deletion of the HD could indirectlyaffect intermolecular interactions...
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Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
... accompanied by improved bind-ing to longer ligands (up to five atoms in the mainchain) and retained binding to shorter ligands [55]. Of the 21 changes in the evolution of R7 fromnative GLYAT ... some of the key findings that have led to our current under-standing of the molecular mode of action of glypho-sate and the molecular basis for glyphosate resistance.Structure and function of ... d-amino acid oxidase [47]. In B. subtil-is, GO is involved in biosynthesis of the thiazolemoiety of thiamine pyrophosphate (vitamin B1). Thisreaction requires the direct transfer of the imine...
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Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx
... 2737 Molecular basis of perinatal hypophosphatasia withtissue-nonspecific alkaline phosphatase bearinga conservative replacement of valine by alanine atposition 406Structural importance of the ... a result of the synthesis of an excess amount of TNSALP (Fig. 1C, lanes 4–6, see the top of gel). In the present experiment, TNSALPs were expressed Molecular basis of perinatal form of hypophosphatasia ... 3B),further supporting that the folding and assembly pro-cess and subsequent intracellular trafficking of TNSALP (V406A) are largely normal in the stable cellline.Kinetics of the soluble form of TNSALP...
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Báo cáo khoa học: Molecular basis of toxicity of Clostridium perfringens epsilon toxin ppt
... activa-tion of the toxin in the gastrointestinal tract compro-mises the intestinal barrier of intoxicated animals,allowing the dissemination of toxin via the bloodstreamto the main target organs of ... that toxin-inducedoedema of the brain is due to the damaging action of the toxin on vascular endothelial cells [45]. Toxin-induced increase in vascular permeability in the brainwas initially ... necrosis of neuronal cells [54]. In intravenously injected mice, pre-injection of pro-totoxin inhibited preferential accumulation and lethalactivity of radiolabelled toxin in the brain, indicatingthat...
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Báo cáo khoa học: Molecular basis of cytokine signalling – theme and variations docx
... the main bindingdeterminants of the IL-4 ⁄ IL-4Ra ligand–receptor interaction, contrib-uting more than 80% of the overall binding free energy. (A) Theside chain guanidinium group of Arg88 of ... can possibly be explained by thehomodimeric nature resulting in four binding interfaces for a single Noggin molecule.W. Sebald et al. Molecular basis of cytokine signallingFEBS Journal 277 ... and core structure) the contribution of the individual binding interfaces can be small. (B) The binding of two N-terminal VWC domains of CV-2 (grey, left in surface representation) to the dimeric...
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Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc
... with GDP (red) obtained usingMOE software. (B) Close up of the purine ring binding site in theC-terminal domain. Lines indicate hydrogen bonds interactions. Let-tering in red corresponds to ... carbon 2 of the guanine ring may interact withthe side chain of Glu309, whereas the carbonyl group atposition 6 of the guanine ring may interact with thehydroxyl group of the Tyr239 side chain (Figs ... modelingprocedure, exploring the conformational space of side-chain rotamers in the presence of GDP to induce theirfitting. This procedure was programmed in moe in order to construct and minimize...
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Tài liệu Báo cáo khoa học: Improving Classification of Medical Assertions in Clinical Notes" pdf
... LinguisticsImproving Classification of Medical Assertions in Clinical Notes Youngjun Kim Ellen Riloff Stéphane M. Meystre School of Computing School of Computing Department of Biomedical Informatics ... recall gains on the minority classes. 1 Introduction Since the beginning of the new millennium, there has been a growing need in the medical community for Natural Language Processing (NLP) ... the training data to measure the impact of each of the four subsets of features explained in Section 3. Ta-ble 3 shows the cross validation results when cu-mulatively adding each set of features....
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Báo cáo khoa học: " THE DISTRIBUTION OF WORD LENGTH IN TECHNICAL RUSSIAN" pdf
... theoretical interest of this distribution arises from the possibility of using it as a basis for an operational definition of words in printed texts. If texts are considered purely as sequences of ... not shared by the others, of being concentrated at relatively low values of length, and of having no elements exceeding a certain length (Fig. 1). Words, defined in this fashion, can readily ... identified by a machine and they are of limited variety, so that their listing in a dictionary is practicable. From the practical point of view, the distri-bution is useful in planning input and storage...
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Báo cáo khoa học: "Classification of Feedback Expressions in Multimodal Data" pdf
... predicting listener backchannels. Au-tonomous Agents and Multi-Agent Systems, 20:70–84, Springer.Gabriel Murray and Steve Renals. 2008. DetectingAction Meetings in Meetings. In Proceedings of the ... MUMIN Coding Scheme for the Annotation of Feedback, Turn Management and Sequencing. Mul-timodal Corpora for Modelling Human MultimodalBehaviour. Special Issue of the International Jour-nal of ... In Pro-ceedings of SIGDIAL 2009: the 10th Annual Meet-ing of the Special Interest Group in Discourse andDialogue, September 2009, pages 253–261, QueenMary University of London.Nina Grønnum....
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Báo cáo khoa học: Molecular basis for specificities of reactivating factors for adenosylcobalamin-dependent diol and glycerol dehydratases pptx
... enzyme-bound, adenine-lacking cobalamins for free adenosyl-cobalamin, an adenine-containing cobalamin throughintermediary formation of apoenzyme. The function of reactivating factors is to ... consideredmodels of the damaged cofactor (adenine-lackingcobalamin) and intact coenzyme (adenine-containingcobalamin), respectively. As shown in Fig. 3A, whenthe diol dehydratase–CN-Cbl complex was incubatedwith ... to result in the dissociation of a tightly bound damaged cofactoror adenine-lacking cobalamin [36,37]. To elucidate the molecular basis of the specificities of reactivating fac-tors in the reactivation...
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