Báo cáo khoa học: Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential doc

... controlsubstance in this context, because it is an inhibitor of P-glycoprotein rather than MPTP, and is devoid of calcineurin-inhibiting properties [23].We hypothesized that an increase in steady-stateDWmunderlies ... 3003–3012 ª 2007 The Authors Journal compilation ª 2007 FEBS Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential Marco van der Toorn1, ... the electron transfer chain [13]. This results in an increased likelihood of leakage of electronsfrom the chain, with increased ROS production as a consequence [14].One mechanism by which the...

Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx

... of the questions within an analysis of the hypothesis in the context of a characterization of the "how" of the entire behavior. By adapting HOPE for processing French, we furthermore ... often are not translated into meaning preserving sentences in English. An example sentence demonstrating this is: Ce singe aime le cafe. (This monkey likes coffee.) The degradation of these same ... background in current linguistic research on French. This will include an overview of recent relevant psycholinguistic and neurolinguistic studies in French. Then we will present an overview of computational...

Báo cáo khoa học: A novel mass spectrometric approach to the analysis of hormonal peptides in extracts of mouse pancreatic islets ppt

... performed in orderto get an overview of the many compounds of the pancreaticislet extract (Fig. 1a). The prominent signals in the spectrumoriginated from products of proinsulin. Two insulin variantsare ... 60–80% of the islets and as insulin makes up almost20% of the proteins in the b-cells, proinsulin-derivedpeptides can be expected to constitute quantitatively pre-dominant components of the extracts. ... proinsulin.Insulin1and2andC-peptide1and2wereidentiﬁed, while the other prominent peaksrepresent the B-chain of insulin (*) and the truncated form of the C-peptide (**). Highmass accuracy is provided...

Báo cáo khoa học: Fasting-induced oxidative stress in very long chain acyl-CoA dehydrogenase-deﬁcient mice pdf

... analysis revealed thatwith an LCT diet and no fasting, the expression of AOXwas signiﬁcantly higher in VLCAD KO mice than in WT mice. Fasting induced a signiﬁcant increase in bothgenotypes; ... [1]. The pathophysiology behind the hepatic damage is not well understood. Oxidative stress has often beendiscussed, but has never been proven. To gain insightsinto the pathogenetic mechanisms involved ... assembly and secretion of VLDL.Overall, there is increasing evidence that an inheritedenzyme defect in mitochondrial b-oxidation also affectsmany other pathways of lipid metabolism [13]. The transcription...

Báo cáo khoa học: Human skin cell stress response to GSM-900 mobile phone signals In vitro study on isolated primary cells and reconstructed epidermis docx

... placed at the centre of the cross-linker at adistance of 13.5 cm (minus the height of the culturedish) from the UV lamp. The apparatus calculates the duration of exposure as a function of the desired ... cannot be ruledout. However, as we did not detect any overproliferationor increase in thickness in this model, we suggest that the slight increase in Hsp70 seen in hRE does not trans-late into ... We did not obtain suchresults in isolated keratinocytes, possibly because of alack of cell differentiation in cell layers. The relevance of this 3D model in approaching the real organ in phototoxicity...

Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx

... [103].Crohn’s disease is an in ammatory disease of the small intestine and ⁄ or the colon. As mentionedalready, in the small intestine, the pathogenesis is asso-ciated with a reduced expression of the ... peptide and of other unusual iso-forms of the peptide. The current thinking is that, atleast partially, the chronic in ammation results from the increased chemotactic and angiogenic activity of the ... recently.Human a-defensins and b-defensins induce the release of histamine and prostaglandin D2 in a G-protein–phospholipase C-dependent manner [62] [71]; HPN1–3bind C1q and activate the classic...

Tài liệu Báo cáo khoa học: Pyrimidine-speciﬁc ribonucleoside hydrolase from the archaeon Sulfolobus solfataricus – biochemical characterization and homology modeling doc

... mixture of 95% methanol and 0.1% triﬂuoroacetic acid in H2O. The retention times of adenosine and adenine, inosine and hyp-oxantine, guanosine and guanine, uridine and uracil, cyti-dine and cytosine ... cytosine were 12.2 and 6.2 min, 10.5 and 4.7 min,15.2 and 6.1 min, 6.8 and 4.2 min and 6.6 and 3.9 minrespectively. The amount of purine or pyrimidine baseformed is determined by integrating the ... accordingto Facchiano et al. [48].Docking of ribose and Ca2+into the binding site of SsCU-NH was performed using, as a starting reference, the position of the sugar and of the metal in the crystallo-graphic...

Tài liệu Báo cáo khoa học: Molecular characterization, phylogenetic relationships, and developmental expression patterns of prion genes in zebraﬁsh (Danio rerio) doc

... part of the intestine (Fig. 5M,Q,R). This lastfinding should be of interest because in terms of func-tion, the fish intestine is highly regionalized both in the larva and in the adult [38]. The ... independentduplications; the first round resulting in the ancestrallong repeat unit and the second giving the repeatsfound in the zebrafish PrP1 sequence. Analysis of the Fig. 3. Alignment of the N-terminal amino ... in cranial ganglia including the trigeminalganglia and their projections (Fig. 4A,B,D,E). The hybridization signal was maintained in the ganglia upto the larval stages (Fig. 4G–J,L) while an...

Tài liệu Báo cáo khoa học: "NATURAL VS. PRECISE CONCISE LANGUAGES FOR HUMAN OPERATION OF COMPUTERS: RESEARCH ISSUES AND EXPERIMENTAL APPROACHES" doc

... that they are in control of the system and not the system in control of them. Equally, nothing can be more damaging to satisfactory system opemtion, regardless of how well all other aspects of ... about the data stored in the machine. An understanding of onto/into mappings, one-to-one/one-to-many/many-to-many relationships, set theory, boolean algebra, or predicate calculus and the proper ... of great assis- tance in formulating queries. Mathematicians (and musicians, chemists, knitters, etc.) have long relied on precise concise notations because they help in problem solving and...

Tài liệu Báo cáo khoa học: "Language Resources Factory: case study on the acquisition of Translation Memories" potx

... if the workflow is robust (i.e. makesuse of retry and parallelisation) and the error is confined to a WS (i.e. it does not affect the rest of the workflow). An instance of Biocatalogue and one of ... to get familiar with the characteristic bilingual terminology and otheraspects of the domain. Another obvious potential use of this data would be to use it to train a Statis-tical MT system.Three ... align-ment and conversion to TMX.1 IntroductionA fundamental issue for many tasks in the field of Computational Linguistics and Language Tech-nologies in general is the lack of Language Re-sources...

Xem thêm