Báo cáo khoa học: Towards understanding the functional role of the glycosyltransferases involved in the biosynthesis of Moraxella catarrhalis lipooligosaccharide ppt
Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka pptx
... [5]. In the present minireview, the expression of relaxin-3 in the brain, and particularly its functions, including the stress response and food intake, are described.Expression of relaxin-3 in the ... consists of sig-nal peptides, and a B-chain, C-peptide and A-chain,and contains the RXXXRXXI motif in the B chain(B12–B19 in human) for binding to the relaxin recep-tor [3]. Similar to insulin, ... expressed in the brain and testis. In rodent brain, ana-tomical studies have revealed its predominant expression in neurons of the nucleus incertus of the dorsal pons, and a few other regions of the...
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Báo cáo khoa học: A novel prokaryotic L-arginine:glycine amidinotransferase is involved in cylindrospermopsin biosynthesis potx
... andl-arginine:glycine amidinotransferase (EC 2.1.4.1) involved in creatine biosynthesis in vertebrates [26]. In cylindrospermopsin biosynthesis, the amidinotransfer-ase CyrA is thought to catalyze the ... [24,27,30,34]. The best studied amidinotransferases are l-arginine:inos-amine phosphate amidinotransferase (EC 2.1.4.2; StrB1) involved in the biosynthesis of the antibiotic streptomy-cin in the soil ... closes,regulating access to the active site. Binding of the large s ubstrate ⁄ product (l-arginine ⁄ ornithine) to AGATinduces the open conformation of the lid, whereasbinding of the small substrate...
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Báo cáo khoa học: Towards understanding the functional role of the glycosyltransferases involved in the biosynthesis of Moraxella catarrhalis lipooligosaccharide ppt
... investigate the function of the glycosyltransferase enzymes involved in the biosynthesis of lipooligosaccha-ride of M. catarrhalis and to gain some insight into the mechanism of sero-type specificity ... strain (asproposed by Edwards et al. [5]). The elucidation of the biosynthetic pathway of LOS structures of knownserotypes will allow further examination of the role of LOS in pathogenesis. In ... that there is competi-tion between glycosyltransferases Lgt1 and Lgt4.Results In order to investigate the function of the glycosyl-transferase enzymes involved in the biosynthesis of LOS of...
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Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt
... two termini of the inserted Ca2+-binding sites in the model structure of the EF-hand of STIM1 is within15 A˚. Accordingly, a total of six glycine linkers is suffi-cient to enable the grafted ... the initial mixture. The fluorescence intensity wasnormalized by subtracting the contribution of the baselineslope using logarithmic fitting. The Tb3+-binding affinity of the protein was obtained ... Ca2+. According to calculationsusing the spherical shape of macromolecules, the hydrodynamic radius of the protein will increase by27% on formation of the dimer [22]. The increase in size for...
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Báo cáo khoa học: Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain pdf
... good inhibitors of the asymmetrical hydrolases, having Kivalues within the range of the Kmfor Ap4A. By contrast, none of the six analogs were good substrates orinhibitors of the bacterial ... cleavage of dinucleoside polyphosphate molecules modified in theirADP moieties. In addition, none of the oxymethyleneanalogs investigated inhibited the hydrolysis of Ap4Acatalyzed by the E. ... could arise either from weaker binding of 3 in the active site of the hydrolase in the reverse orientation(Fig. 3B) or from a reduced rate of cleavage. WhileABFig. 2. Time course of ApOpCH2OpOpA...
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Báo cáo khoa học: NrpRII mediates contacts between NrpRI and general transcription factors in the archaeon ¨ Methanosarcina mazei Go1 pot
... further verifying formation of a complexbetween NrpRI and NrpRII. The presence of 10 mm2-oxoglutarate significantly decreased the binding of MBP–NrpRI to the operator as well as the binding of the ... completeloss of repression in M. maripaludis, whereas the muta-tion of the corresponding amino acid in the first NrpRdomain (S168A) retained a normal regulation [22]. If the second NrpR domain of M. ... binding of NrpRI to the nifH promoter in the presence of NrpRII was analysed. E. coli cell extractscontaining MBP–NrpRI and (His)6–NrpRII were com-bined in a 1 : 1 ratio and promoter-binding...
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Báo cáo khoa học: "Towards Open-Domain Semantic Role Labeling" doc
... + AC chain.4.1 The Role of Lexical Clustering The first study aims at detecting the impact of dif-ferent clustering policies on the resulting AC ac-curacy. Clustering, as discussed in Section ... about the relation r. In ANC the percentage of times that the Eq. 5 isbacked off against test instances (as h or r arenot available from the training data) is twiceas high as in the BNC-FN or in ... scores. Finally, the final space is obtained by applying the SVD reduc-tion over M, with a dimensionality cut of l = 250. In the evaluation of the AC task, accuracy iscomputed over the nodes of the...
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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt
... from the results listed in Table 1 that most, if not all, of the amylose issynthesized in vivo when the rate of amylopectin synthesisbecomes minimal. At these moments the rates of amylopec-tin ... further distinguished fromglycogen by the presence of highly ordered parallel arrays of double helical glucans (reviewed in [5]). The origin of these arrays resides in the close packing of the ... rate of amylopectin synthesis. The increase in crystallinity wit-nessed during these first 12 h is in line with the high ratesobserved for amylopectin synthesis. However between 12and 58 h the...
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Báo cáo khoa học: hhLIM is a novel F-actin binding protein involved in actin cytoskeleton remodeling ppt
... identi-fication of their actin-binding domains. To date, none of the actin-binding domain sequences registered in databases is present in hhLIM or CRPs. The goals of this study were to define the actin-binding ... the second LIM domain plays a central role in bundling of F-actin. Taken together, these data identify hhLIM as an actin-bindingprotein that increases actin cytoskeleton stability by promoting ... includedSM22a, a known actin cross-linking protein, and BSA,which does not interact with or cross-link actin. In the absence of hhLIM, the majority of actin remained in the supernatant (S) and...
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Tài liệu Báo cáo khoa học: Molecular modeling and functional characterization of the monomeric primase–polymerase domain from the Sulfolobus solfataricus plasmid pIT3 doc
... step increase of 0.2 nm, and a bandwidth of 1 nm. Thermal stability of Rep245 was measured by incu-bating the protein at 60, 70 and 80 °C for 30 min and thenrecording the CD spectra of the incubated ... structure–sequenceanalysis The N-terminal domain comprising residues 31–245 of the orf915-encoded putative replication protein of the plasmid pIT3 was predicted to be the minimum-lengthsequence containing all the functionally ... it.Another significant finding concerns the nature of the acid residues within the active site of Rep245. The carboxylate triad of Rep245 including the D101, D103and D166 motif is similar to the...
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