Báo cáo khoa học: Expression and functional characterization of P2Y1 and P2Y12 nucleotide receptors in long-term serum-deprived glioma C6 cells ppt

... onResearch and development in information retrieval,pages 411–418, Singapore. ACM.Wayne Xin Zhao, Jing Jiang, Hongfei Yan, and Xiaom-ing Li. 2010. Jointly modeling aspects and opin-ions with ... 2008. Opinion mining and sentiment analysis. Foundations and Trends in Infor-mation Retrieval, 2(1-2):1–135.Ana-Maria Popescu and Oren Etzioni. 2005. Extractingproduct features and opinions ... Ryan McDonald. 2008. A joint model of text and aspect ratings for sentiment summarization. In Proceedings of the 46th Annual Meeting of the As-sociation of Computational Linguistics: Human Lan-guage...

... antigenicdeterminants and the functional domains of TC havenot been identified.Cloning [5–7] and recent expression of several kind-red Cbl-binding proteins [8–11] helped to elucidatesome of their ... EV,McLoughlin P & Morgan AC (1996) Synthesis of coba-lamin–biotin conjugates that vary in the position of cobalamin coupling. Evaluation of cobalamin derivativebinding to transcobalamin II. ... notdone.mAbEpitopeclusterPrecipitation of Apo-TC (%)Precipitation of Holo-TC (%)Inhibition of precipitationby heparinb(%)Blocking of recptorbinding (%)Blocking of Cbl binding(%)3-9a1 20–50 70–90...

... data describing the catalytic cycle of twomammalianperoxidases,LPOandMPO,inordertoreconcile the apparent inconsistencies and to provide somenew insights. MPO and LPO share functional and structural ... existence of two Cpd I isomers both in MPO and LPO. In the case of MPO the evidence is: (a) the EPR spectrum of a trapped amino acid radical found by Lardinois et al.[48] in at least one catalytic intermediate ... which is involved in LPO dimerization and has no catalytic role. Tyr289 couldalso be involved in H2O2-mediated cross-linking betweenLPO and myoglobin [55]. The precise identity of the secondresidue...

... [22] and increased extracellular Cu causes an increased turnover of PrPc[23]. Binding of Cu to the protein in uences its abilityto interact with other proteins such as plasminogen [24] and glycosaminoglycans ... activity.We determined that the active site consists of two domains.The first includes the Cu-binding domain and the secondincludes the conserved hydrophobic domain in the middle of the protein. Additionally, ... Gerstmann–Stra¨ussler–Scheinker syndrome[6]. All of these disease are linked together because of thedeposition of an abnormal, protease-resistant isoform of theprion protein in brains of individuals with...

... probes and optical spectroscopy are nowentering a phase enabling the in vivo interrogation of the role of oligomers in amyloidosis. Such techniques used in parallel with in vitro experiments, of increasing ... efficiency changes uponprotein binding. Recently, new antibody stains have allowed precise moni-toring of the oligomer size and distributions using multicolor labelling and single molecule detection. ... a-synuclein,apolipoprotein C-II and insulin. To obtain information on the progression of the intermediate states, these were monitored in terms of fluorescenceparameters, such as anisotropy, and quantum...

... restrictions in Hebrew on the co-occurrence of several determiners in the same NP and on their relative order- ing within the NP. To explain them, Glin- ert (Glinert, 1989) adopts a functional ... following open problems in the resulting sample: the selection of the unmarked realization option and the deter- mination of the default value of the definite feature remain difficult and vary ... considering the case of partitives and pos- sessives in a bilingual Hebrew-English gen- eration grammar. In the case of bilingual generation, the ultimate goal is to provide a single input...

... and kinetic constantsrelated to the binding of l-Arg [10–14] and NOHA[10], nothing is known about the thermodynamics and kinetics of the binding of guanidines and N-hydroxy-guanidines to iNOS. ... modes of binding of N-hydroxyguanidines to NO synthases: first evidence forthe formation of iron–N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining thebinding mode. ... variation in koffas a function of the iNOSsubstrate structure.Kinetics of the binding of guanidines and N-hydroxyguanidines to iNOSoxymeasured bystopped-flow UV ⁄ Vis spectroscopyAn iNOSoxysolution...

... are beingmeasured within the intact network operating in its cellularenvironment (i.e. either in the intact cell or at least in a celllysate) and adopting a sufficiently large spectrum of differ-ent ... take into account only the in uence of substrates and products on the reaction rate. The rate of meta-bolic enzymes determined by network perturbations of intact cells [6,7] is inevitably in uenced ... complex than in the case of varying energetic load (see Appendices S3 and S4). Increasing rates of GSH consumption areparalleled by increasing rates of NADPH consump-tion. A decrease in the NADPH...

... earlier in this paper. The results are obtained using the two-stage training schedule, including six iterations for training phrase translation models and two iterations for training lexicon ... the baseline and also over training phrase or lexicon models alone. The two-stage training of both models gives the best result of 27.33%, outperforming the baseline by 1.1 BLEU points. More ... machine translation. In Proc. of EMNLP 2008. Xinyan Xiao, Yang Liu, Qun Liu, and Shouxun Lin. 2011. Fast Generation of Translation Forest for Large-Scale SMT Discriminative Training. In Proc....