Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
... Authors Journal compilation ª 2007 FEBS BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL- induced apoptosis in breast cancer cells Latricia D. Fitzgerald1,*, Charvann ... 22-foldenhancement in apoptosis relative to cells expressing BRCA1 in the absence of TRAIL and a three-foldenhancement of apoptosis over that induced by TRAIL in the presence of the empty vector. Thus, the data ... and induce apoptosis in breast cancer cells. Therefore, we assessed the requirementfor functional BRCA1 in TRAIL- stimulated apoptosis. HCC1937 cells have a 5382insC mutation in BRCA1, resulting...
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Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx
... pregnenolone synthesis in recombinant yeast. In conclusion, the SCC reaction appears to be regulatedsimilarlyinyeastandinadrenalcells;inthelatter,Adxpandnot Adrp limits the activity of CYP11A1 and hence ... the CYP11A1antigen appears to be excluded from mitochondria in vivo, and most of the antigen is detected in the plasma membrane,with a minor fraction localizing to the ER. To determine whether ... to the inner mitochondrial membrane [11]. In contrast, the factors and processes responsible for the intracellular supplyof cholesterol to the outer mitochondrial membrane arepoorly understood....
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Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf
... vectors containing the mutations of the miR-23a binding site (Fig. 4A). It was shown thatmiR-23a ASO or pcDNA3 ⁄ pri-23a did not affect the intensity of EGFP fluorescence in the vector bearing the ... fluorescentreporter, and found an increase in EGFP intensity afterblocking miR-23a and a decrease in EGFP intensityafter overexpressing miR-23a. Furthermore, anotherthree reporter vectors containing mutations ... containing mutations of the miR-23a binding site were used in the fluorescentreporter assay. The reporter vector containing a muta-tion of the first binding site showed no response to altered miR-23a...
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Tài liệu Báo cáo khoa học: Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells docx
... sixfoldincrease in hepatocyte nonheme Fe. This strongly suggests arole for the liver in binding, storing and detoxifying excessbody Fe in the form of plasma NTBI. While these hepatoma cells took ... a big increase in the proportion of Fe in the cytosolsuggest that all the chelators including DFO and DFP, act in part intracellularly, mobilizing Fe from ferritin butforming Fe-chelator complexes ... studies, there appeared to be a shift from the membrane-bound fraction to the cytosolic compartments, while the proportion of Fe incor-porated into ferritin remained within the range obtained forthe...
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Báo cáo khoa học: Structural flexibility of the methanogenic-type seryl-tRNA synthetase active site and its implication for specific substrate recognition pptx
... of the conserved arginine residues in the motif 2 loop show aconcerted movement following substrate binding in the active site. In the apo-enzyme, the motif 2 Arg336occupies the adenine-binding ... which is in close proximity to the negativelycharged carboxylate group of the amino acid sub-strate [21]. The binding of ATP and the amino acidsubstrate in the active site are linked, and incorrectbinding ... incorrectbinding of ATP can affect serine binding and viceversa [22]. Asn435, together with Asp416 and Glu432,contributes to binding of the Mg2+ion between the a- and b-phosphates of ATP. Indeed,...
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Báo cáo khoa học: Structural study of the catalytic domain of PKCf using infrared spectroscopy and two-dimensional infrared correlation spectroscopy pot
... functional domains and motifs, including a PB1domain in the N-terminus, a pseudosubstrate (PS)sequence, a C1 domain of a single Cys-rich zinc-fingermotif, and a kinase domain in the C-terminus. The catalytic ... increase). It seems,then, that this substrate was able to modulate the sec-ondary structure significantly. To gain further insight into the structure and foldingof cat-f and into the structural changes ... with the maximum intensity, will be surrounded by sixcontour lines, whereas the rest of the peaks will show anumber of contour lines reflecting their intensities in rela-tion to the main peak....
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Báo cáo khoa học: Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways doc
... interaction.Dematin and Ras-GRF2 associate in mouse brain lysate and in transfected epithelial cells To test whether Ras-GRF2 and dematin associate in vivo,we examined their association in mouse brain lysate ... domain ofRas-GRF2 stimulates the activation of the MAP kinaseERK1 and Ras upon in ux of intracellular calcium in A293 cells [22,26]. First, we wanted to test whether the binding ofdematin to the ... It is therefore plausible that the direct binding of dematin to the DH domain of R as-GRF2may provide a functional link between Ras signaling and the actin cytoskeleton.Elucidation of the crystal...
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Báo cáo khoa học: Identification of the N-termini of NADPH : protochlorophyllide oxidoreductase A and B from barley etioplasts (Hordeum vulgare L.) ppt
... foundN-terminal to the arginine. Alanine or threonine isfound C-terminal to the processing site. Similar aminoacids are present around the processing site in POR ofpea. Glutamine has been found to ... modifies the N-terminal amino groups of internal peptides, the hydrophobicity of the corresponding peptides isincreased, leading to a delay in the retention timeduring chromatographic separation. In ... homologous to the N-terminal amino acid of PORA (Fig. 4). The twoadditional N-terminal peptides of PORB both startwith the amino acid alanine. In parallel with the lossof one and two amino groups, the...
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Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish pdf
... chelate one zinc ion each, and binds to the minor groove of the DNA [6]. Dmrts wereoriginally described to play important roles during sexdetermination in flies and worms by regulating severalaspects ... FEBSrather than being continuously mature individuals. In general, for males, abundant dmrt1 expression duringpreparatory and prespawning and spermatogenesisperiods was seen, in contrast to a ... dmrt1 inactivation in either the Sertoli cells or the germ cells indicated that mouse Dmrt1 is indeedrequired for radial migration of germ cells and survivalof gonocytes. It is also required autonomously...
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Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt
... from the R1 subunit back to the tyro-sine Y122 of the R2 subunit; and (d) dedocking of the product deoxyribonucleotide and reductionof the disulfide cysteine by NADPH. In in vitro stud-ies, the ... [35] may not be considered in the light of the results obtained in the present study. Rather, the involvement of manganese in the in vivo assembly of the metallocofactor of C. ammoniagenes R2F ... using l-tryptophan-con-taining standards to simulate the protein background. Forexample, in GF-AAS, high contents of the organic matrixwill generate microscopic particles in the gas phase insidethe...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ