Báo cáo khoa học: Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling pot
Tài liệu Báo cáo khoa học: A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3 pptx
... at the interface between the a and b subunits.A comparison of the amino-acid sequences showed that the ADP-bindingmotif in the a subunit of PDH1 clearly differs from that in the a subunit of ... stream from the 5¢-terminus of the predic-ted ORF, is the proper initial codon for a2. The N-ter-minal amino-acid sequences of the b2 and c2 subunitscorresponded to the sequences of the predictedPH1751 ... show the amino-acidalignment of the a and b subunits of PDH1, PDH2 and T. profundus dye-l-proDH. The amino-acid sequence of the a1 subunit of PDH1 showed 31% and 32% identi-ties with the a2...
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Báo cáo khoa học: Abortive translation caused by peptidyl-tRNA drop-off at NGG codons in the early coding region of mRNA potx
... inhibitgrowth of the strain even in the presence of IPTGinduction. All of these results suggest that the low geneexpression associated with NGG codons in the down-stream region following the initiation ... paus-ing at early NGG codons is the reason for the observed low gene expression. The length of the peptidyl moiety of the peptidyl-tRNA in uences the drop-off process in the case of very small mini-genes ... analysed argininecodons AGA, CGC, CGA and CGU. The amino acidsequence of the nascent peptide is the same in all of these cases. This fact eliminates any amino acid contri-bution by the amino acid...
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Báo cáo khoa học: Activated transglutaminase from Streptomyces mobaraensis is processed by a tripeptidyl aminopeptidase in the final step pptx
... Ne-(c-glutamyl)lysine bonds, the incorpor-ation of polyamines into proteins, the deamidation of protein-bound glutamines, and the covalent attachment of proteins to lipids such as x-hydroxyceramides ... distinct differ-entiation stages. Culture on agar plates containing glucose,yeast and malt extracts allows the organism to developsubstrate and aerial mycelia culminating in the formation of spores ... furtherenhanced by the addition of small amounts of CaCl2.Forinstance, Ala-Pro-pNA was hydrolysed in the presence of 50 lMCa2+at double the normal rate. Further increasing the Ca2+concentration...
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Tài liệu Báo cáo khoa học: Purification and characterization of a membrane-bound enzyme complex from the sulfate-reducing archaeon Archaeoglobus fulgidus related to heterodisulfide reductase from methanogenic archaea pdf
... locus of A. vinosum, the DsrJ protein. The mature form of the AF503 protein contains an N-terminal hydrophobic s tretchpredicted to form a transmembrane a helix, which mayanchor the protein in the ... DsrK, and HmcFclearly identified the t wo typical CXXCXXCXXXCPbinding motifs for [4Fe-4S] clusters in the N-terminal part of these proteins. AF502, DsrK, and HmcF also containone of the two ... N-terminal Ôtwin-arginineÕ signal sequence that ischaracteristic of cofactor-containing proteins translocatedinto the periplasm via the Tat translocase [27]. As deducedfrom the N-terminal sequence...
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Báo cáo khoa học: Trafficking and proteolytic processing of RNF13, a model PA-TM-RING family endosomal membrane ubiquitin ligase pot
... ubiquitination in endosomes, on the plasma membrane, in the cytoplasm, in the nucleoplasm or on the inner nuclear membrane, with the site(s) regulated by signaling events that modulateprotein targeting and ... tags and RNF13 CTFs arefound in purified INM fractions [46].This signal-induced movement to the INM places the RING domain in the nucleoplasm and the PAdomain between the two nuclear membranes. ... EGFR superfamily of tyrosine kinases [55,56] and APP [24,57]. The growingappreciation of the role of both the nuclear membrane [58,59] and endosomes [60] in the regulation of tran-scription...
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Báo cáo khoa học: Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells pptx
... peptidemap, and most of the input masses were matched to the candidate protein sequences. The majority of the trypticpeptides matched with the theoretical masses within62 p.p.m. MALDI-TOF MS data of the ... adipo-philin and perilipin genes have been revealed, and analysis of the 5¢ flanking region of the PP17 gene has shown anumber of potential transcription factor binding sitesindicating its complex ... inducedapoptosis and PP17b synthesis in HeLa cells, which wassignificantly inhibited by protein kinase C (PKC) inhibitor,indicating the involvement of NF-jB and AP-1 transcriptionfactors in...
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Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx
... [125I]TC-PCSK9 binding toHepG2 cells (data not shown), further supporting the specificity of the binding.Estimation of binding affinity of wild-type and two mutant variants of PCSK9 In preliminary saturation ... First, the number of LDLRs on HepG2cells increased following growth in the absence of lipo-proteins, and there was a corresponding increase in the binding of [125I]TC-PCSK9 and [125I]TC-PCSK9-D374Y. ... wild-type and two gain -of- function mutants of PCSK9 reduced binding of [125I]TC-PCSK9. The Scatchard plot of the binding-inhibition curve was curvilinear, indicative of high-affinity and low-affinity...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... domain of t-bet, the STAT protein inter-action domain, STAT protein all-alpha domain, STATprotein DNA-binding domain and SH2 domain of stat6, and the zinc-finger domain, leucine-zipperdomain and ... proteins, a leucine zipper domain and a C2H2 zinc finger domain, both of which arethought to help mediate DNA binding and may beinvolved in the induction of dimerization [43]. Each of these ... expression of T-bet has beenseen within a wide variety of tissues and cells in the Ginbuna crucian carp [27] and, in mammals, in the lung tissue of mouse and spleen and thymus of human and mouse...
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Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx
... we show, for the first time, that PGD2isinvolved in the activation of adipogenesis and regula-tion of insulin sensitivity in vivo. Further characteriza-tion of the role of PGD2 in adipocyte ... more in WAT of TGmice than in WAT of WT mice.Serum levels of triglyceride, glucose, leptin and insulin, and insulin sensitivity, in TG miceAfter 6 weeks of normal or HF diet, serum levels of triglyceride, ... resulting in pronounced adi-pogenesis and increased insulin sensitivity. The present study provides the first evidence that PGD2participates in the differentiation of adipocytes and in insulin...
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Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt
... conditions of elevated leptin and NPY by overexpressing NPY in the hypothalamus of Y2) ⁄ )mice [25]. These animals had a marked increase in leptin levels, and thereby an increase in body weight and ... 3665(ruling out the possibility of an autocrine, paracrine orendocrine mechanism of regulation in the ob ⁄ obmodel), and given that the majority of leptin receptorsexist in the arcuate nucleus of ... link between the mechanisms of action of NPY and leptin in the regulation of bonemass. Moreover, it led to the hypothesis that NPYmight be a common mediator underlying the highbone mass in...
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Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ