Báo cáo khoa học: Functional role of the linker region in purified human P-glycoprotein pot

Báo cáo khoa học: Functional role of the linker region in purified human P-glycoprotein pot

Báo cáo khoa học: Functional role of the linker region in purified human P-glycoprotein pot

... This kinetic analysis provided new insight into the role of the linker region. In addition, we fur- ther analyzed the functional role of the linker region based on the crystal structures of a ... cleavage of the linker [22]. Although these results provided valuable suggestions for the role of the P-gp linker region, the molecular details, such...
Ngày tải lên : 29/03/2014, 23:20
  • 13
  • 313
  • 0
Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf

Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf

... preventing binding of oxygen. We analyzed the azide inhibition and determined the inhibition constants for sodium azide, in order to see the effect of the mutation (L559A) on the binding properties ... stability of the trinuclear site is decreased, the binding of azide to the trinuclear site may be decreased. The depletion of the T2 copper and chloride ion may...
Ngày tải lên : 16/03/2014, 00:20
  • 16
  • 452
  • 0
Tài liệu Báo cáo khoa học: Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance pptx

Tài liệu Báo cáo khoa học: Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance pptx

... base-pairs in the centre of the junctions [19]. Detailed understanding of the functional role of these interactions would require the crystal structure of the Ydc2–junction complex. In this study the ... [14,20]. Binding of CCE1 results in the complete unpairing of the four base-pairs in the centre of the junctions with a lesser disruption of t...
Ngày tải lên : 20/02/2014, 11:20
  • 11
  • 575
  • 0
Báo cáo khoa học: Functional role of Bb-chain N-terminal fragment in the fibrin polymerization process pdf

Báo cáo khoa học: Functional role of Bb-chain N-terminal fragment in the fibrin polymerization process pdf

... situated in the E-domain of the fibrin molecule, the complementary site ‘c’ is suggested to be situated in the D-domain. We have tried to model the intermolecular binding between the D-domain of one ... the N-terminal region of the Aa-chain by the splitting off of fibrinopeptide A [6]. Site ‘a’ is formed by amino acid residues cGln329, cAsp330, cHis340 and cAsp36...
Ngày tải lên : 30/03/2014, 03:20
  • 10
  • 575
  • 0
Tài liệu Báo cáo khoa học: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation ppt

Tài liệu Báo cáo khoa học: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation ppt

... to DEC1 in the region between amino acids 48–124 of DEC1. This region, including the bHLH domain, coincided w ith t he r egion required for bo th the suppressive activity of DEC1 and the interaction ... Arg65, is responsible for t he E-box binding. Determination of the region in BMAL1 for binding to DEC1 To identify the region in BMAL1 required for the binding...
Ngày tải lên : 19/02/2014, 16:20
  • 11
  • 629
  • 0
Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx

Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx

... obtained by other groups who also point to the role of the connecting loop of the b-hairpin of defensins. A combination of mutational analysis [35] and structural analysis of the plant defensin Rs-AFP1 ... molecule comprising Ôresidues in the protruding domain consisting of the type VI b-turn and the first part of b-strand 3Õ (i.e. the b-hairpin loop and part...
Ngày tải lên : 20/02/2014, 11:20
  • 9
  • 598
  • 0
Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf

Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf

... this protease at pH9 [10]. Further interest in the aromatic stacking is in the role of the electrostatic properties in enzymatic catalysis of API, and in distinguishing the functionally catalytic quadruple ... position. In the struc- tural deviation, the solvent ASA of the side-chain of His210 increased with the decrease in size of the side-chain at r...
Ngày tải lên : 21/02/2014, 03:20
  • 7
  • 603
  • 0
Báo cáo khoa học: Functional association of the AAA complex and the peroxisomal importomer potx

Báo cáo khoa học: Functional association of the AAA complex and the peroxisomal importomer potx

... Pex15p. To investigate the in uence of individual peroxins of the importomer on the composition of the membrane- bound AAA complex, we selected gene deletion strains affected in the docking complex ... a control. The corresponding solubilisates (right panel) were analyzed for the presence of Pex1p and Pex6p as indicated. The defici- ency of either protein of the...
Ngày tải lên : 07/03/2014, 12:20
  • 12
  • 458
  • 0
Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx

Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx

... hydrolysis, resulting in an increase in intracellular sterol trafficking. It is unclear, then, whether the corresponding increase in pregnenolone pro- duction results from an increase in free sterol ... ([14,15]). In the latter case, the concentration of Adrp limits the production of pregneno- lone [15] through a mechanism involving oxidized Adxp, that is in excess in...
Ngày tải lên : 08/03/2014, 08:20
  • 13
  • 441
  • 0
Báo cáo khoa học: Functional analysis of the aglycone-binding site of the maize b-glucosidase Zm-p60.1 pot

Báo cáo khoa học: Functional analysis of the aglycone-binding site of the maize b-glucosidase Zm-p60.1 pot

... anal- ysis of plant b-glucosidases to obtain insights into the evolution of the molecular sites involved in the two modes of aglycone binding. The amino acid sequence of Zm-p60.1 was com- pared with the ... distances of reacting atoms. The only noted difference was in the orienta- tion of the aromatic ring of pNPGlc in the F193A mutant (Fig. 6D), owing to...
Ngày tải lên : 16/03/2014, 04:20
  • 13
  • 400
  • 0

Xem thêm

Từ khóa: