Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx

Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx

Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx

... studies have established a direct correlation between obesity and the development of cardiovascular disease [36,37]. Despite the pivotal role of obesity and dyslipidemia in the development of the ... lipo- protein transport system have not yet been investigated thoroughly. In this minireview, we focus on the current literature pertinent to the involvement...
Ngày tải lên : 29/03/2014, 22:21
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Báo cáo khoa học: Catalytic residues Lys197 and Arg199 ofBacillus subtilis phosphoribosyl diphosphate synthase Alanine-scanning mutagenesis of the flexible catalytic loop ppt

Báo cáo khoa học: Catalytic residues Lys197 and Arg199 ofBacillus subtilis phosphoribosyl diphosphate synthase Alanine-scanning mutagenesis of the flexible catalytic loop ppt

... both the wildtype enzyme, the K197A enzyme and the R199A enzyme. The K-values, obtained by fitting the data to Eqn (1), and assuming the binding of ATP before Rib5P (see below), are presented in ... Characterization of alanine variants of the remaining amino acid residues of the flexible loop revealed an effect on the K m values, whereas the effect on the k c...
Ngày tải lên : 23/03/2014, 15:20
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Báo cáo khoa học: Lipins from plants are phosphatidate phosphatases that restore lipid synthesis in apah1Dmutant strain of Saccharomyces cerevisiae ppt

Báo cáo khoa học: Lipins from plants are phosphatidate phosphatases that restore lipid synthesis in apah1Dmutant strain of Saccharomyces cerevisiae ppt

... sufficient to completely hinder enzyme activity. To determine whether the previous results with respect to enzyme activity were related to other effects on lipid metabolism, we examined the yeast ... residues in the HAD-like motif of the plant enzymes are required for PAP function, and demonstrate the importance of conserved glycine and serine residues for the activity...
Ngày tải lên : 15/03/2014, 00:20
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx

Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx

... endocrine milieu that regulates the fibroelastic properties of the penis via tissue maintenance and remodeling. The evidence presented in the literature regarding obesity and ED, and as discussed in ... vascular bed of the penis; (b) the endothelium lining the cavernosal arteries and the helicine arterioles, as well as the endothelium lining the lacunar sp...
Ngày tải lên : 18/02/2014, 06:20
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Báo cáo khoa học: Mechanisms of obesity and related pathologies: Transcriptional control of adipose tissue development pdf

Báo cáo khoa học: Mechanisms of obesity and related pathologies: Transcriptional control of adipose tissue development pdf

... incidence of these diseases is expected to double by the year 2030 and the associated healthcare expenditure will be > $100 billion in the USA alone [2,3]. The increased incidence of obesity, ... in the mature adipocyte and facilitates the expression of multiple proteins regulating insulin sensitivity, including the insulin-dependent glucose transporter GLUT4...
Ngày tải lên : 29/03/2014, 22:21
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Báo cáo khoa học: Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue pdf

Báo cáo khoa học: Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue pdf

... adipocyte ‘secretome’ ranges from molecules of direct metabolic relevance to those with effects unrelated to metabolism. These include the adipocyte-specific proteins adiponectin and leptin, the in ammatory ... overall health, despite an even further expansion of the Fig. 1. Interactions between expanding adipose tissue and the endothelium via adipokines. Adipokines induce a r...
Ngày tải lên : 29/03/2014, 22:21
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... resulted in the opposite pheno- type to what was expected [34] and needs to be explored further. Other areas of the brain have also been shown to regulate feeding via AMPK [35,36]. Of interest ... nutrient sensing in the brain and is an example of an enzyme that can sense and respond to the nutritional environment. The major challenge to understanding the role o...
Ngày tải lên : 14/02/2014, 22:20
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Báo cáo khoa học: Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulfiram potx

Báo cáo khoa học: Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulfiram potx

... To test whether the DS-dependent inhibition of NAT1 is a result of reaction at the active site cysteine residue, we carried out protection experiments in the presence of the physiological acetyl ... been used for decades to treat alcoholism. Its therapeutic effect is thought to be mediated by the irreversible inhibition of aldehyde dehydrogenase. Recent reports have indica...
Ngày tải lên : 07/03/2014, 02:20
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Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata pot

Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata pot

... to contribute to the enrichment of arachidonate in PtdIns in mammals. Further experiments are needed to clarify the involvement of the PtdIns cycle in the accumulation of arachidonic acid in PtdIns of ... respectively. These results obtained in the presence of large amounts of docosahexaenoic acid are in good agreement with the distribution patterns of ar...
Ngày tải lên : 08/03/2014, 08:20
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Báo cáo khoa học: Mechanisms of amyloid fibril self-assembly and inhibition Model short peptides as a key research tool pptx

Báo cáo khoa học: Mechanisms of amyloid fibril self-assembly and inhibition Model short peptides as a key research tool pptx

... were obtained when the phenylalanine residue of the medin hexa- peptide fragment was replaced with alanine or with the more hydrophobic amino acid, isoleucine [18]. The overall results of these ... to those of the native peptide [24]. The role of aromatic interactions Taken together, the results of these peptide studies indicate that very simple motifs contain all t...
Ngày tải lên : 23/03/2014, 11:20
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