... studies have
established a direct correlation between obesity and
the development of cardiovascular disease [36,37].
Despite the pivotal role of obesity and dyslipidemia in
the development of the ... lipo-
protein transport system have not yet been investigated thoroughly. In this
minireview, we focus on the current literature pertinent to the involvement...
... both the wildtype
enzyme, the K197A enzyme and the R199A enzyme.
The K-values, obtained by fitting the data to Eqn (1),
and assuming the binding of ATP before Rib5P (see
below), are presented in ... Characterization of alanine variants
of the remaining amino acid residues of the flexible
loop revealed an effect on the K
m
values, whereas the
effect on the k
c...
... sufficient to completely
hinder enzyme activity.
To determine whether the previous results with
respect to enzyme activity were related to other effects
on lipid metabolism, we examined the yeast ... residues in the HAD-like motif of the
plant enzymes are required for PAP function, and
demonstrate the importance of conserved glycine and
serine residues for the activity...
... endocrine milieu that
regulates the fibroelastic properties of the penis via
tissue maintenance and remodeling. The evidence
presented in the literature regarding obesity and ED,
and as discussed in ... vascular
bed of the penis; (b) the endothelium lining the
cavernosal arteries and the helicine arterioles, as well
as the endothelium lining the lacunar sp...
... incidence of
these diseases is expected to double by the year 2030
and the associated healthcare expenditure will be
> $100 billion in the USA alone [2,3]. The increased
incidence of obesity, ... in the mature adipocyte and facilitates
the expression of multiple proteins regulating insulin
sensitivity, including the insulin-dependent glucose
transporter GLUT4...
... adipocyte ‘secretome’ ranges
from molecules of direct metabolic relevance to those
with effects unrelated to metabolism. These include the
adipocyte-specific proteins adiponectin and leptin, the
in ammatory ... overall
health, despite an even further expansion of the
Fig. 1. Interactions between expanding adipose tissue and the
endothelium via adipokines. Adipokines induce a r...
... resulted in the opposite pheno-
type to what was expected [34] and needs to be
explored further. Other areas of the brain have also
been shown to regulate feeding via AMPK [35,36].
Of interest ... nutrient sensing in the
brain and is an example of an enzyme that can sense
and respond to the nutritional environment. The major
challenge to understanding the role o...
... To test
whether the DS-dependent inhibition of NAT1 is a
result of reaction at the active site cysteine residue,
we carried out protection experiments in the presence
of the physiological acetyl ... been used for decades to treat alcoholism. Its therapeutic
effect is thought to be mediated by the irreversible inhibition of aldehyde
dehydrogenase. Recent reports have indica...
... to
contribute to the enrichment of arachidonate in PtdIns in
mammals. Further experiments are needed to clarify the
involvement of the PtdIns cycle in the accumulation of
arachidonic acid in PtdIns of ... respectively.
These results obtained in the presence of large amounts of
docosahexaenoic acid are in good agreement with the
distribution patterns of ar...
... were obtained
when the phenylalanine residue of the medin hexa-
peptide fragment was replaced with alanine or with
the more hydrophobic amino acid, isoleucine [18].
The overall results of these ... to those of the native
peptide [24].
The role of aromatic interactions
Taken together, the results of these peptide studies
indicate that very simple motifs contain all t...