... MINIREVIEW
Roles of prolactin-releasing peptide and RFamide related
peptides in the control of stress and food intake
Yuki Takayanagi and Tatsushi Onaka
Division of Brain and Neurophysiology, ... progress
in research investigating the roles of these two peptides
in the control of energy metabolism and stress.
PrRP
PrRP was considered...
... and
transduction of the measurement of galactose to the
nucleus through protein–protein interaction leading to
gene expression. The status of the switch is determined by
the state of the upstream ... element of the GAL
genes in the nucleus. The regulatory protein may bind to
the upstream regulatory element constituting a protein–
DNA interaction [4–6]. The...
... SH3
domain in the same protein, and that this intramolecu-
lar interaction suppresses the lipid-binding activity of
the PX domain in the resting state; phosphorylation of
p47
phox
releases the binding, ... domains
play important roles in the function of proteins contain-
ing this domain [40]. In particular, p47
phox
, which con-
tains the PX domain and two SH...
... may
AB
Fig. 5. The role of the C-terminal, HBXIP interacting, domain of hSuv3p in protein stability. (A) The protein stability of the wildtype hSuv3TAP
and the hSuv3TAP variant lacking the C-terminal 136 ... decline in the truncated protein levels
within 4 h following inhibition of protein synthesis by
cycloheximide. We next wanted to examine whether the
presence...
... be
involved in signaling processes related to the regulation
of synaptic plasticity by binding to the adaptor protein
PSD95. This protein contains several PDZ domains one
of which binds to the ... C-terminal amino acids
of the NMDA receptor. This particular feature was
exploited for the retrieval of a PSD95-containing complex
by immobilizing a hexapeptide corresponding t...
... chain
corresponding to the catalytic domain (C domain);
and the B chain corresponding to the translocation
domain (T domain) and the receptor-binding domain.
The C and T domains remain covalently linked ... of the pro-
tein in the N state and the evolution of the overall
structure of the protein in the MG state. This degree
of resolution is unpreceden...
... striking feature of the
structure is an inherent asymmetry among the catalytic
b subunits. In combination with the asymmetric loca-
tion of the central c subunit, and in accordance with
the binding ... to
clarify whether the stoichiometry of the c rings is
in uenced by variation of the expression level of
subunit c.
In the present study we investigated whe...
... role of AP-2a and AP-2e
in chondrogenesis. Overview of the differen-
tiation stages during chondrogenesis and
the involvement of transcription factors
(henatoxylin and eosin-stained section of ... helix–span–helix domain at the C-terminus shown in blue medi-
ates dimerization and, together with the basic domain, (red) DNA-binding. ‘*’, amino acids that are identical...
... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in
hindbrain except for the midbrain, hindbrain midline. Surprisingly, the HSF2 ... would enhance or diminish the impact of
HSF2 deficiency.
Pending questions for the roles of HSF1 and
HSF2 in oogenesis and in early embryos
The role of HS...
... per
monomer of poly(dT), showing that the changes were
mainly due to the binding of the first DNA, while the
binding of the second DNA had less in uence
(Fig. 5A). To ensure that the estimation of the ... located, and are not found at the ATP-binding site
or the subunit–subunit interface of the Rad51 filament.
Therefore, the Rad51 L1 and L2 loops may also be...