Báo cáo khoa học: Importance of the gating segment in the substrate-recognition loop of pyranose 2-oxidase pptx
Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated transcript. Taken together, these findingsprovide a compelling argument for the role for malo-nyl-CoA in regulating ... and certain amino acids [16].A linkage between fatty acid synthesis in the CNSand feeding behavior was uncovered with the findingthat systemic or intracerebroventricular administration of fatty ... needs to beexplored further. Other areas of the brain have alsobeen shown to regulate feeding via AMPK [35,36]. Of interest is the extensive use of fructose as asweetener in the human diet [37]....
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
... from the other bran-ches, which was indeed predicted. The other maingroup, obtained 97% of the time in 20 740 exploredtrees, contained the DIDO PHD sequences clusteredwith the PHF and the ... analyses The localization of the DIDO1 gene in the context of chromatin stability was addressed experimentally.Although the experiments conducted were preliminary,they indicated the involvement of ... inhi-bitor of growth protein 3 (ING3) PHD, which isanother domain involved in chromatin binding andclearly more divergent (e-value 0.019) from DIDO and the other sequences. As the alignment...
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Báo cáo khoa học: Monomeric molten globule intermediate involved in the equilibrium unfolding of tetrameric duck d2-crystallin pdf
... stabilityfor crystallins is essential in maintaining lens transparency[4]. Determining the mechanism of folding and assembly of these proteins is important for understanding how they canform stable ... concentrations. The d2-crystallin in lens was recruited during evolutionfrom argininosuccinate lyase, an enzyme involved in arginine biosynthesis derived from the urea cycle. Thesetwo proteins shared ... further increased. The unfolding curveusing the ANS fluorescence probe suggested a multistateprocess, consistent with the results obtained by proteinintrinsic fluorescence and CD. The binding...
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Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx
... chain is brefeldin A-insensitive and isinhibited by the proteasome inhibitor clasto-lactacystinb-lactone, resulting in the accumulation of ricinA chains. These stabilized ricin A chains are partlydeglycosylated ... pivotal role of the UPR is to maintain ER home-ostasis. Therefore, the presence of mutated proteinsthat are unable to fold into their native conformation in the ER induces the UPR in an effort ... peptide in the 24-kDa a-zein and the 19-kDa a-zein endosperm storage proteins, respect-ively. These mutant proteins are translocated into the lumen of the ER, but remain anchored to the mem-branes...
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Báo cáo khoa học: A novel retinol-binding protein in the retina of the swallowtail butterfly, Papilio xuthus docx
... staining of the gel indicates that the fluorescing protein is one of the major components of soluble proteins in the crude extract. The surface of the fluorescing protein carries negative charge in ... cellular retinal-binding protein; CRBP,cellular retinol-binding protein; IRBP, interphotoreceptorretinoid-binding protein; RBP, retinol-binding protein.Note: The nucleotide sequence reported in this ... ligand-binding protein in the fly chemosensoryhair [26]). The calculated pI value of the Papilio RBP is 4.92; the protein is highly acidic. This explains the high mobility of the protein in the native...
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Báo cáo khoa học: 2-Oxo acid dehydrogenase complexes in redox regulation Role of the lipoate residues and thioredoxin pot
... Rather, the advantageappears to depend on the ability of the lipoyl group toprotrude from the inner core of the complex, indicative of the biological significance of the complex-bound lipoateinteraction ... In view of the redox-sensingfunction of the lipoate/dihydrolipoate couple of the complex (Fig. 3) and the intimate link between thiscouple and E1, the E1 dissociation from the complex tobind ... Anotheressential feature of the lipoate residues within the 2-oxoacid dehydrogenase complexes arises from the ÔcrowdingÕeffect. Confinement of the complex-bound lipoate within the volume of the...
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Báo cáo khoa học: Succinate dehydrogenase flavoprotein subunit expression in Saccharomyces cerevisiae – involvement of the mitochondrial FAD transporter, Flx1p ppt
... strains to obtain the newstrains reported in Table 1.Genomic HA-tagging of SDH1Three consecutive copies of the HA epitope were fused to the 3¢-end of the SDH1 ORF in the genome of both the WT ... for the quantitation of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.55 Laemmli UK (1970) Cleavage of structural proteinsduring the ... role in maintaining the normalactivity of mitochondrial FAD-binding enzymes, including lipoamidedehydrogenase and succinate dehydrogenase flavoprotein subunit Sdh1p. Adecrease in the amount of...
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Báo cáo khoa học: Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases ppt
... by decreasing the rate of cleavagebetween the two subdomains of the A domain. Thesefindings were later explained with the structural modelthat the smaller subdomain AC of the A domainrotates ... consisted of the firsttwo functional domains, namely the phenylalanine-specific A domain and the PCP domain. The terminalE domain was excised (the exact amino acid composi-tion of the investigated ... for the investigation of the highly homologous protein tyrocidine synthetaseI (TycA) in its apo-form. They found that the addition of the substrates slowed down the proteolysis of the protein,...
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Tài liệu Báo cáo khoa học: A genetic screen identifies mutations in the yeastWAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation docx
... were raised in rabbitsagainst a GST-War1p fusion protein containing 294 aminoacids of the C-terminal part of War1p (amino acids 650–944) fused in- frame to the C-terminus of GST. The genefusion ... DNA-binding zinccluster at the N-terminus, whereas the acidic activationdomain is usually present at the C-terminus. The mid-dle homology region (MHR) bridging the DNA-bind-ing and the activation ... expression of the C-terminal 294 amino acids of WAR1 fused in- frameto the C-terminus of GST. Escherichia coli strain DH5aharboring pCG1950 was grown on 37 °CtoanA600 of 0.5.Expression of the GST-War1p...
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Tài liệu Báo cáo khoa học: "A HYBRID APPROACH TO REPRESENTATION IN THE JANUS NATURAL LANGUAGE PROCESSOR" pot
... defining the set of items that have ever been the actor in a flight. Their definition is solely within NIKL using the QUA link [14], which is exactly the set of fillers of a slot. While having ... expressions in inten- sional logic. 3 4. Use of the Taxonomy in Janus By domain mode/we mean the set of axioms en- coded in NIKL regarding the constants. The domain model serves several purposes in ... all of the definitions of approximately 200 items from the base vocabulary using the defini. tJons of those vocabulary items themselves in the dictionary. In this attempt, we encountered the...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Chuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015