Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... determines the fate of the internalized receptors.
Other examples of the reciprocal in uence of receptors
in the internalization process are the adrenergic a
1a
and a
1b
receptors [ 21] , neurokinin ... GPCR–b-arres-
tin interaction. (A) The sequential binding
of the ligands to each half of the receptor
dimer induces the recruitment of two
molecules of b...
... algorithms
and the selection of the sequences in the alignment
determine the nature of the answers returned by the
application of the computational tools. The statistical
nature of these tools makes their ... changes that occur during evo-
lution at one of the interaction interfaces must be com-
pensated by changes in the other interacting protein
in orde...
... determined by a number of fac-
tors, including the rate of unfolding, the amino acid
sequence of the protein, the experimental conditions
and the nature of the intermediate state(s) that form
[1, 2]. ... no in uence of the additive
on the chaperone activity of aB-crystallin (i.e. the effect of
the additive on the aggregation of the target protein is...
... 3–9.
19 Thomas JO & Khabaza AJ (19 80) Cross-linking of his-
tone H1 in chromatin. Eur J Biochem 11 2, 5 01 511 .
20 Kunkel GR, Mehrabian M & Martinson HG (19 81)
Contact-site cross-linking ... 2008)
doi :10 .11 11/ j .17 42-4658.2008.06522.x
The folding of eukaryotic DNA into the 30 nm fibre comprises the first
level of transcriptionally dormant chromatin. Understandin...
... reduction in the binding affinity was
observed in the case of binding of the M.HhaI with
the X
+
CG ⁄ CGM duplex containing the (+)-cis-B[a]P-
N
2
-dG adduct on the 5¢-side of the target dC residue.
The ... with the intercalative
conformation of the (+)-cis adduct and the minor-
groove conformation of the (+)-trans adduct, the lat-
ter interfering with...
... enhanced cytotoxicity of
Topotecan in both cells. In contrast, NAC enhanced resistance
against doxorubicine and vincristine in MRP1 overexpressing
cells. We conclude that Quercetin and NAC may have ... leads to the generation of recombino-
genic intermediates. DNA recombination enables the cells to
cross the mitotic boundary, but the damage that remains kills the...