Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc

Báo cáo khoa học: The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology pptx

Báo cáo khoa học: The impact of G-protein-coupled receptor hetero-oligomerization on function and pharmacology pptx

... determines the fate of the internalized receptors. Other examples of the reciprocal in uence of receptors in the internalization process are the adrenergic a 1a and a 1b receptors [ 21] , neurokinin ... GPCR–b-arres- tin interaction. (A) The sequential binding of the ligands to each half of the receptor dimer induces the recruitment of two molecules of b...
Ngày tải lên : 16/03/2014, 22:20
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Báo cáo khoa học: The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics doc

Báo cáo khoa học: The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics doc

... algorithms and the selection of the sequences in the alignment determine the nature of the answers returned by the application of the computational tools. The statistical nature of these tools makes their ... changes that occur during evo- lution at one of the interaction interfaces must be com- pensated by changes in the other interacting protein in orde...
Ngày tải lên : 16/03/2014, 22:20
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Tài liệu Báo cáo khoa học: The occurrence of hemocyanin in Hexapoda docx

Tài liệu Báo cáo khoa học: The occurrence of hemocyanin in Hexapoda docx

... (PamHc2) and Sh. lateralis (StaHc2). Hexapod hemocyanin subunits 1 We completed the fragments of ScuHc1, MgeHc1, CmoHc1, CacHc1, HmeHc1, CseHc1, BduHc1 and PamHc1 using 5¢- and 3¢-RACE (Table 2). The ... (kDa) cDNA (bp) 5¢-UTR (bp) ORF (bp) 3¢-UTR (bp) ScuHc1 FM242638 217 8 37 2 016 12 5 672 19 653 75.59 FcaHc1 FM242650 10 53 – – – 3 51 – – – MgeHc1 FM242639 2208 30 2058 12...
Ngày tải lên : 18/02/2014, 08:20
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

... determined by a number of fac- tors, including the rate of unfolding, the amino acid sequence of the protein, the experimental conditions and the nature of the intermediate state(s) that form [1, 2]. ... no in uence of the additive on the chaperone activity of aB-crystallin (i.e. the effect of the additive on the aggregation of the target protein is...
Ngày tải lên : 18/02/2014, 16:20
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Tài liệu Báo cáo khoa học: The sequentiallity of nucleosomes in the 30 nm chromatin fibre pptx

Tài liệu Báo cáo khoa học: The sequentiallity of nucleosomes in the 30 nm chromatin fibre pptx

... 3–9. 19 Thomas JO & Khabaza AJ (19 80) Cross-linking of his- tone H1 in chromatin. Eur J Biochem 11 2, 5 01 511 . 20 Kunkel GR, Mehrabian M & Martinson HG (19 81) Contact-site cross-linking ... 2008) doi :10 .11 11/ j .17 42-4658.2008.06522.x The folding of eukaryotic DNA into the 30 nm fibre comprises the first level of transcriptionally dormant chromatin. Understandin...
Ngày tải lên : 18/02/2014, 18:20
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Tài liệu Báo cáo khoa học: The stereochemistry of benzo[a]pyrene-2¢-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases pptx

Tài liệu Báo cáo khoa học: The stereochemistry of benzo[a]pyrene-2¢-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases pptx

... reduction in the binding affinity was observed in the case of binding of the M.HhaI with the X + CG ⁄ CGM duplex containing the (+)-cis-B[a]P- N 2 -dG adduct on the 5¢-side of the target dC residue. The ... with the intercalative conformation of the (+)-cis adduct and the minor- groove conformation of the (+)-trans adduct, the lat- ter interfering with...
Ngày tải lên : 19/02/2014, 00:20
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Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx

Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx

... were cultured in a 1 : 1 mixture of DMEM and Ham’s F12 medium containing 5% fetal bovine serum, insulin (10 lgÆmL )1 ), ferritin (10 lgÆmL )1 ), selenium (1 ngÆmL )1 ) and antibiotics. Cells at 60% ... development. Cell 11 5, 513 –5 21. 46 Strous G & Govers R (19 99) The ubiquitin–proteasome system and endocytosis. J Cell Sci 11 2 , 14 17 14 23. 47 Hicke...
Ngày tải lên : 19/02/2014, 00:20
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... charge EIE max (kT) BS-RNase 10 0 10 0 10 0 18 )63.8 HHP-RNase 51 103 10 0 10 )67.3 RNase AA-GG 71 109 10 0 10 )44.3 RNase AA-G 28 58 0 8 )27.3 RNase AA 12 0 0 6 )14 .0 Fig. 3. Lipid mixing of DMPG vesicles induced by ... +39 0 81 67 915 9 Tel: +39 0 81 67 915 7 E-mail: dalessio@unina.it (Received 12 April 2006, revised 31 May 2006, accepted 12 June 2006) doi :10 .11 11/ j ....
Ngày tải lên : 19/02/2014, 06:20
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Tài liệu Báo cáo khoa học: Transient silencing of Plasmodium falciparum bifunctional glucose-6-phosphate dehydrogenase) 6-phosphogluconolactonase docx

Tài liệu Báo cáo khoa học: Transient silencing of Plasmodium falciparum bifunctional glucose-6-phosphate dehydrogenase) 6-phosphogluconolactonase docx

... 90.00 ± 14 .14 10 ± 14 .14 nd pHC1 48 1. 99 ± 0.53 nd 10 0 nd 96 0.52 ± 0 .16 nd 99.0 ± 1. 00 0.7 ± 0 .10 pHC1G6 PD-AS 48 2 .16 ± 0 .19 nd 10 0 nd 96 0.47 ± 0.06 nd 96.7 ± 1. 00 3 .1 ± 0 .16 a To determine parasitaemia, ... confirming the key role of this enzyme in the intraerythrocyte stage of infection. Results Effects of PfG6PD-6PGL gene silencing on growth and pa...
Ngày tải lên : 19/02/2014, 07:20
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Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx

Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx

... enhanced cytotoxicity of Topotecan in both cells. In contrast, NAC enhanced resistance against doxorubicine and vincristine in MRP1 overexpressing cells. We conclude that Quercetin and NAC may have ... leads to the generation of recombino- genic intermediates. DNA recombination enables the cells to cross the mitotic boundary, but the damage that remains kills the...
Ngày tải lên : 19/02/2014, 07:20
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