... prevent the relapse of ATL in
postallogeneic stem cell transplantation patients.
The expression of Tax by the host cell targets them
for attack by CTL, resulting in the elimination of the
infected ... unpulsed T2 -A2 cells as target cells,
specific cytotoxic activity was evaluated by FCM assay of cell- mediated cytotoxicity. All tests were carried out in triplicate at effector : target
r...
... downstream elements that ultimately
converge at the EXECUTER1 and EXECUTER2 genes. Most of the intermediates in this pathway have not yet been identified and are there-
fore highlighted with a ... hypersensitive
response-like cell death symptoms [92]. Taken together,
these results emphasize that signals other than SA, JA
and ethylene must be involved in the regulation of cell
death i...
... sense,
5¢-CCGAGATCTGGCTTTTACTTAAACCG-3¢; IL6R
antisense, 5¢-CAGGAATTCACTTGCTCTGTCACCC-3¢;
GAPDH sense, 5¢-GCGAATTCCGTGTCCCCACTGCC
AACGTGTC-3¢; GAPDH antisense, 5¢-GCTACTCGAGT
TACTCCTTGGAGGCCATGTGG-3¢. The ... expressed as the means ± standard devia-
tion (SD) and statistical analysis utilized a two-tailed Stu-
dent’s t- test. Statistical significance was set at P £ 0.05.
Acknowledgements
We...
... exert their toxic effect through other targets in
addition to, or instead of, the CBPs; this deserves fur-
ther and thorough investigation.
Despite their structural similarity, atropine and
ipratropium ... elution process, indica-
ting that N-substitution is a minor determinant in the
protein–ligand interaction, provided that the substitu-
ent is hydrophobic [26]. On the other hand, when...
... activation, and both required to
ensure plasmin anchorage and subsequent proteolytic
activity. These structural and functional transitions
are determinant in the initiation and acceleration of
fibrinolysis ... anchorage and functioning. Both
K1- and K4-LBS support Lys-plasmin(ogen) binding
and activation. These structural–functional transitions
are determinant in the initiation...
... compartment (Fig. 7).
This indicated that the silenced cells, albeit retaining D
identity, failed to maintain stable interactions with
other D cells and sorted-out towards the V compart-
ment. This ... related
to its human counterpart, sharing with it 66% identity
and 79% similarity. The conservation increases
remarkably within several specific domains, so that
total identity exists betwee...
... the
reticulum of endothelial cells [32]. Thus, it is likely
that epithelial, mesangial and endothelial cells can all
contribute to renal cholinesterase activity, but the
most important point is the comparable ... acetylcholinesterase mRNAs, their lifespan
and translational efficiency, and the capacity of the
translated product to bind to protein partners.
The upregulation of butyrylcholi...
... present and activ-
ated in the system. Another could be that the intracellu-
lar concentrations of ATP (Mg) are high enough to
attenuate observed inhibition. Alternatively, it may well
be the case ... in the presence and
absence of ATP. K
app
m
is the apparent dissociation constant for full
length GST-IjBa substrate at saturation concentration of 60 l
M
ATP, and the dissociation constan...
... activator system plays a central role
in wound healing, inflammatory and tissue dissolution,
and cell invasion and metastasis. Tumor cells need to
penetrate the extracellular matrix (ECM) and the ... 5¢-GTCACCACA
GGCTAGCTACAACGACCAGGCACT-3¢
Dz483 (mutant) 5¢-ACACCACTG
GGCTAGCTACAACGATCACGGACC-3¢ 483 nt
Dz720 (active) 5¢-GAGCATCCA
GGCTAGCTACAACGAGGGTGCTGT-3¢
Dz720 (mutant) 5¢-TAGAGCCA...
... proteins into an active form and in the
degradation of regulatory proteins that prevent PCD.
Thus, cysteine proteases that interact with cystatin may
be good candidates for activities that execute ... cystatin A (stefin A) in
the binding of target proteinases: characterization by kinetic and
equilibrium methods of the interactions of cystatin A Gly-4
mutants with papain, cathepsin B, and...