Báo cáo khoa học: Tec family kinases: regulation of FceRI-mediated mast-cell activation ppt
Báo cáo khoa học: Tec family kinases: regulation of FceRI-mediated mast-cell activation ppt
... FEBSMINIREVIEW Tec family kinases: regulation of FceRI-mediated mast-cell activation Wilfried Ellmeier, Anastasia Abramova and Alexandra SchebestaDivision of Immunobiology, Institute of Immunology, ... during mast-cell activation. Tec fam-ily kinases (TFKs) represent another class of proteintyrosine kinases that are implicated in FceRI-mediated mast-cell activation [22]. The Tec kinase family ... regulator of cytokine production in mast cells. Tec is essential for efficient cytokineproduction upon FceRI-mediated mast-cell activation Tec is the third member of the Tec kinase family forwhich...
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Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot
... implicating Tec kinase signaling in multiple levels of regulation of cytokine production.Itk and the regulation of cytokine-producing innate T-cell populationsThe contributions of TFKs to peripheral ... major activa-tor of the Ras–Raf–ERK pathway in T cells. Mutation of Itk prevents full activation of Ca2+mobilizationand ERK activation – these defects are worsened bymutation of both Rlk ⁄ Txk ... expression of Txk, amember of the Tec family of tyrosine kinases, inpatients with Behcet’s disease. Clin Med Res 4, 147–151.5 Smith-Garvin JE, Koretzky GA & Jordan MS (2009)T cell activation. ...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... Tec family kinases Itk and Rlk ⁄ Txk in T lym-phocytes: cross -regulation of cytokine production andT cell fates. FEBS J 278, 1980–1989.41 Qi Q, Kannan AK & August A (2011) Tec family kinases: ... cells, the expression of ITK is extremely lowand often undetectable in immunoblot analysis. The activation of CD4+cells, however, dramaticallyinduces transcription of the ITK gene and is ... recipient of a PhDFellowship from the Ministry of Higher Education andScientific Research ⁄ KRG-Erbil, Iraq.References1 Ortutay C, Nore BF, Vihinen M & Smith CI (2008)Phylogeny of Tec family kinases:...
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Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx
... (2011) Tec family kinases: regulation of FceRI-mediated mast-cell activation. FEBS J 278, 1990–2000.4 Schwartzberg P, Finkelstein L & Readinger J (2005) Tec- family kinases: regulators of T-helper-cell ... results in the development of i NKT ab and cd T cells. Note that in the case of the TCR, these pathways seem to beshared (negative regulation of PLZF, positive regulation of ERK), but lead to different ... member of the Tec family of nonreceptor protein tyrosinekinases which includes Rlk and Tec, and is importantfor effective signaling through the T-cell receptor(TCR) [1,2]. There are additional Tec...
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Báo cáo khoa học: MicroRNAs and the regulation of fibrosis potx
... large amounts of ECM leading finally to liverfibrosis [33].A number of reports have demonstrated an impor-tant role of miRNAs during the activation of HSCs.Thus, measurement of the changes ... development of diabetic nephropathy throughthe down -regulation of PTEN and the subsequent acti-vation of Akt (Fig. 1) [43]. Increased expression of miR-377 is also thought to regulate the expression of fibronectin, ... subsequent activation of the PI3K-Akt pathwayincreased the expression of matrix metalloproteinase-2,which is known to degrade ECM and permit theinfiltration of fibroblasts [24].The miR-29 family...
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Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt
... transcriptional activation of p53, thereby potentiating the expression of pro-apoptotic target genes [21]. The apoptotic signalcan be additionally boosted through the p53-dependentupregulation of PML ... leads to subsequent activation of c-Abl and facilitates p73 transcriptional activation through c-Abl-mediated phosphorylation of p73 atTyr99 [60]. In addition, a key regulator of p73 activity,Yes-associated ... in complete loss of p53 expression. Intumours expressing wild-type p53, its ability to represscancer development often becomes functionally inacti-vated via the upregulation of critical negative...
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Báo cáo khoa học: Gonadotropin-releasing hormone: regulation of the GnRH gene pot
... Because of the recent discovery of GnRH-IIas a new isoform of GnRH, the majority of the studieshave been done on the GnRH-I promoter, and thereare only a few regarding regulation of the GnRH-IIgene.The ... peptide of the GnRH neuropeptide family, beingpresent in animals from jaw fish to humans. The highlyconserved amino acid sequence of GnRH-II in a widerange of species and over millions of years of ... be suitable for studies of regulation of the twoforms of GnRH [83]. Treatment of TE-671 cells withP4(10)6and 10)5m) resulted in increases in GnRH-ImRNA levels of 40 and 100%, respectively,...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... ell-specific dysregulation of thelevels of CB1 m RNA. The overall goal of this research wasto determine how expression of mutant huntingtin selec-tively alters the steady-state mRNA levels of specifictranscripts ... primary cause of HD. Examination o f t he regulation of individual m utanthuntingtin-affected genes such as CB1 may increase ourunderstanding of at least o ne abnormal f unction of mutanthuntingtin ... chemiluminescent detection(Pierce) of the protected probe and RNA ladder.Quantitative RT-PCRQuantitative reverse transcription-PCR (qRT-PCR) wasused to determine the number of copies of mature andunspliced...
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Báo cáo khoa học: Wisely chosen paths – regulation of rRNA synthesis Delivered on 30 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden potx
... formation of the stem–loop structureimpair binding of pRNA to TIP5 and abolish nucleo-lar targeting of NoRC [69].Analysis of the silencing capacity of wild-type ormutant forms of pRNA revealed ... level of regulation of Pol I transcrip-tion, at which TIF-IA not only senses external signalsbut also translates changes in intracellular energysupply into upregulation or downregulation of rRNAsynthesis.Oncogenes ... of strate-gies leading to the molecular characterization of neoplastic diseases, and will drive the design and devel-opment of novel drugs to combat cancer throughtargeted downregulation of...
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Báo cáo khoa học: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric G proteins pptx
... [51].GααβγGPCRAgonistβγGαNo EffectGβγEffectors Activation of GTPase of tubulin by Gα, and inhibition of Loss of GTP cap on MT end by Gαpromotescatastrophy di iPromotion of MT assembly by GβγGTP-TubulinMT ... topromote the GTPase activity of tubulin and subsequent regulation of microtubule assembly [19]. Thus, themodulation of microtubule assembly by G proteinsmay require activation of G proteins by either ... theGDP bound form of Gia and inhibit the exchange of GDP-bound for GTP-bound Ga [73–75]. These signal-ing partners of G proteins might also be involved inthe regulation of microtubule assembly...
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