... hypoglycemia and lacticacidosis [3]. Despite the necessity of glycolysis for survival of the malaria parasite and the distinct molecular character-istics of the parasite e nzyme, the inhibitors ... . The Pf MDH gene did not posses any targeting signal and therefore should be localized to the cytosol. The resultspresented here, and in a recent report [40], clearly demon-strate that this ... lycolysis [ 1], w hich also supplies precursors forseveral other pathways i.e. nonmevalonate pathway ofisoprenoids biosynthesis, fatty acid biosynthesis, purinesalvage, pyrimidine biosynthesis,...