... picolinicacid (PA), quinolinic acid (QA) and NAD homeostasis. Indeed, the enzymestands at a branch point of the tryptophan to NAD pathway, and deter-mines the final fate of the amino acid, i.e. transformation ... cerebral malaria. Int J Parasitol 36,569–582.32 Medana IM, Day NPJ, Salahifar-Sabet H, Stocker R,Smythe G, Bwanaisa L, Njobvu A, Kayira K, TurnerGDH, Taylor TT et al. (2003) Metabolites of the kynurenine ... hepatocyte nuclear factor 4a andperoxisome proliferator-activated receptor a. MolPharmacol 70, 1281–1290.9 Ogata S, Takeuchi M, Fujita H, Shibata K, Okumura K& Taguchi H (2000) Apoptosis...