Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin Jae-Hoon Kim1,*, Kazuki Saito1,2 and Shigeyuki ... N- and C-terminal parts of the ligand are cross-linked to domainsI and III, respectively, of the receptor [19,22]. The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ... activated the chimeras with the ErbB-4 domain I and the ErbB-1 domain III, but not those with the ErbB-1 domain I and the ErbB-4 domain III. Therefore, the relativecontributions between domains I and...
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Báo cáo Y học: A single charged surface residue modifies the activity of ikitoxin, a beta-type Na+ channel toxin from Parabuthus transvaalicus doc
... Hammock11Department of Entomology and Cancer Research Center,2Section of Neurobiology, Physiology and Behavior, and 3Department of Chemistry and Superfund Analytical Laboratory, University of California, ... eachdose.Themicewereobservedfor24h,andeffectswererankedbetween 0 and 10, 0 being no effect and 10 being lethality. The inter-mediate ratings are based on the strength of the symptoms observed, 5 and above is given for heavy tremors and paralysis of hind ... or mechanism of action, the similarity of their effects at other concentrationsraised the possibility that both toxins have a commonmechanism of action. By assessing the effect of these toxinson...
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Báo cáo Y học: Nuclear receptor-dependent transcription with chromatin Is it all about enzymes? pot
... Interestingly, the repression of NR activity by histone H1 can be relieved by the ligand-dependent phosphorylation of H1 by cdk2 (and possiblyother kinases, as well), which leads to the removal of H1from ... thyroid hormone receptor and retinoic acid receptor, have the capacity to activelyrepress the transcription of their target genes in the absence of their cognate ligands [3,4,9,16]. Early competitionexperiments ... contributions of particular HMTs and HATsin the context of a large, NR-dependent transcriptionalregulatory complex may be difficult, as each effect may besubtle and may influence the activity of other factors...
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Báo cáo Y học: Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin a-sarcin potx
... the first step of the reaction. The hydrolysis of the cyclicderivative is performed by the same groups, but their rolesare reversed [23]. In a-sarcin the same roles are fulfilled byHis137 and Glu96, ... by using the dinucleotide ApA as substrate [18]. Both mutant variantshydrolysed ApA. They displayed a Kmvalue similar tothat of the wild-type protein although they exhibited alower catalytic ... characterization of the individual pKavalues of the active site residues, wereconsistent with the existence of two mechanisms for the hydrolysis of ApA with different optimum pH and different...
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Báo cáo y học: "High-Resolution Flow Cytometry: a Suitable Tool for Monitoring Aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment"
... of the investigated TMZ-BioShuttle Cell Cycle and Cell Death Analysis The effects on the cell viability and the cell cycle distribution were determined by DNA flow cytome-try. Flow cytometric ... figure shows the cell cycle distribution of DU 145 cells: In the left part of the figure the plot of the untreated control is demonstrated, the middle and the right plot show the cell cycle distribution ... fraction of the DU 145 cells in the G1 phase allows the DNA-repair and subsequently the re-entry in the cell cycle. Therefore these cells turn out to be refractory against TMZ as shown in the TMZ-based...
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Báo cáo y học: "An Avian Connection as a Catalyst to the 1918-1919 Influenza Pandemic"
... the virulence of a virus is determined by: the efficiency of the hemagglutinin ability to drift; functional ability of the nueraminidase, and the immunity of the host it infects to fight the ... numbers quickly and killing the very young and very old. The association of avian influenza with the 1918 pandemic has not been determined; however, a more probable link still exists with the swine ... necessary to prevent the reappearance of this influenza. Unlike the typical “flu” that strikes the very young, chronically ill and elderly; this flu would attack and kill healthy young adults....
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
... by the 26Sproteasome or, in certain cases, by the lysosomes/vacuole and rapidly degraded. Ubiquitination of target proteinsinvolves a cascade of reactions catalysed by the E1, E2 and E3 enzymes. ... toincubation with another type of primary antibody.Detection of ubiquitinated proteinsUb is highly conserved among eukaryotes, as only three of 76 amino acids differ between the human and yeast proteins.Therefore, ... binding to the P85 subunit: one involves the proline-richdomain of Cbl and the SH3 domain of P85 and while the other implicates a phosphorylated C-terminal tyrosine (Y7 31) of Cbl and an undefined...
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Báo cáo y học: "Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain"
... intrathecally once daily for 7 days, starting from 1 day before CCI surgery. Evaluation of tactile allodynia and thermal hyperalgesia The paw withdrawal latency (PWL) to radiant heat and ... One of the potential ad-vantages of RNAi technologies is the ability to design precisely targeted therapeutics for almost any gene, regardless of the function of the gene product, whether ... to behavioral hypersensitivity (3-5). A cur-rent theory for the etiology of neuropathic pain in-volves CNS immune activation with cytokine pro-duction inducing the expression of final common...
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Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... thrombocythemia (ET) and often in polycythemia vera (PV), myelofibrosis (MF) and chronic myelogenous leukemia. The risks associ-ated with thrombocythemia are thromboembolic events and bleeding, ... by in-hibition of megakaryocyte colony development, thereby reducing megakaryocyte size and ploidy, and disrupting or preventing full megakaryocyte matura-tion. However, little is known of ... cells. It is well established that se-rum levels of TPO are regulated by the binding of the ligand to the receptor and the endocytosis of the ligand -receptor complex [9]. Against that background,...
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Tài liệu Báo cáo Y học: Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) pdf
... transiently transfected with the respective expression plasmids and analyzed by confocalmicroscopy the next day. Full-length GFP-tagged TRAF4molecules were localized in the cytoplasm and were barelydetectable ... 8).Correspondingly, fluorescence of cytoplasmic T4(259–470)–YFP and full-length T4–GFP was already significantly reduced after 2 min of bleaching in a small area of the cytoplasm, whereas the fluorescence of ... functionally distinctpopulations of this molecule. Analyses of the various deletion mutants of TRAF4suggest that the zinc fingers of the molecule are responsiblefor the cytoplasmic retention of TRAF4....
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roTranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ