... exploratory step then hasformed a basis for the parameter space with informationin which directions the objective function decreases. Inthe next step, the pattern move, the informationobtained is ... Kaandorp JA & Blom J (2007)Efficient parameter estimation for spatio-temporalmodels of pattern formation: case study of Drosophilamelanogaster. Bioinformatics 23, 3356–3363.37 Kirkpatrick S, Gelatt ... metaheuristic for parameter estimation in nonlin-ear dynamic biological systems. BMC Bioinformatics 7,483.85 Egea JA, Rodrı´guez-Ferna´ndez M, Banga JR & Martı´R (2007) Scatter search for...