Báo cáo khoa học: "CONTEXT-FREENESS AND THE COMPUTER PROCESSING OF HUMAN LANGUAGES" pot

... i d, and it is left to the bookkeeping phase of the compiler to keep track of declarations and uses of particular names. The bookkeeping has Co be done, of course, even in the case of languages ... generative capacity, and time complexity of recognition. All three of these matters should be of concern to theoretical linguists; the study of what mathematically definable classes human languages ... in the ~ and ~ strings, then the vocabulary of recursive nonterminals would have to be increased in proportion. (The second clause in the defini- tion of profligacy makes it irrelevant whether...

Báo cáo khoa học: Stability and ﬁbril formation properties of human and ﬁsh transthyretin, and of the Escherichia coli transthyretin-related protein potx

... 2011Stability and ﬁbril formation properties of human and ﬁsh transthyretin, and of the Escherichia colitransthyretin-related proteinErik Lundberg1, Anders Olofsson2, Gunilla T. Westermark3 and ... polar residues, Thr75 and His88 (hTTR number-ing), buried within the hydrophobic core of the mono-mers. The side chains of these residues form, togetherwith the Ne1 atom of Trp79, hydrogen bonds ... cold-adapted proteins and distinguishesthem from their mesophilic and thermophilic counter-parts is their lower thermal stability [66]. This couldtherefore be one explanation for the reduced stabilitythat...

Tài liệu Báo cáo khoa học: Molecular and cellular speciﬁcity of post-translational aminoacyl isomerization in the crustacean hyperglycaemic hormone family docx

... terminal in the sinus gland, as a result of late and progressiveisomerization of the Phe3 of the CHH during the migration of the secretion vesicles along the axonaltract [39,41]. The immunohistochemical ... microscopystudy of the neuronal endings in the sinus gland todetermine the subcellular localization of the differentepimers. Taken together, these results allow a discus-sion of the existence of enzyme(s) ... that the two VIH isomers differed by the conﬁguration of the tryptophan at the fourth position of the sequence and, consequently, they were namedVIH and d-Trp4 VIH.This assumption was further...

Tài liệu Báo cáo khoa học: Structural and functional speciﬁcities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx

... cell inﬁltrates of the lung and ﬁbro-sis in the liver [110].Conclusions The novel members, PDGF-C and -D, of the PDGFsubfamily of the cystine knot family of growth factorsare potent cytokines ... removal of the CUBdomains and thereby activation of the growth factordomains. PDGF-C and -D contain both the CUB and growth factor domains when they are secreted and pro-teolytic cleavage is therefore ... a wide scope of biological effects;however further understanding of how these factorsinterplay with other members of the cystine knot family and in particular the PDGF-A, -B, and VEGF growthfactors,...

Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc

... IPU consists of a signal sequence (residues1–19) and a mature part (residues 20–564), and the model iscomposed of residues 25–540. The overall structure of the model of IPU and the mutated residues ... polysaccharide,pullulan.Comparison of the active sites of the model of IPU and Dex49A The active site structures of t he model of IPU (Fig. 4A) and Dex49A (Fig. 4B) were compared. The three Asp residues,Asp353, Asp372 and Asp373, ... enzymeliberated isopanose from pullulan, and isomaltose and glucose from panose, and the action patterns of the wild-type and the W402F enzymes were almost identical (Fig. 2). The kinetic study for W402F...

Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt

... elucidate the role of the positively charged residue Arg78 and the effect of the reduction of cationicity of MBP in the triggering of multiplesclerosis. Flexible docking calculatio ns of the MBP(74–85)epitope ... eycharacteristic of the structure of the native epitope inMe2SO is the presence of a large number of electrostaticinteractions, especially in the central region of the peptide. The side chain of Arg78 ... distantfrom the side chain of Arg78. The side chain of Arg78 is lesswell deﬁned, as in the case of aqueous solution, because of the absence of interactions with the s ide chains of A sp81 (in the agonist...

Báo cáo khoa học: Covalent and three-dimensional structure of the cyclodextrinase from Flavobacterium sp. no. 92 pdf

... between the long B-domain extension of CDase(His251, Fig. 7) and the N-terminal domain of the othersubunit of the TVA-II dimer (Tyr45¢). It has been suggestedthat the N-terminal domain of the ... the loops at the opposite barrel end. The lengths of the b-strands in the barrel vary from two (b14)to seven (b11) residues. As in other enzymes of family no. 13, the regularity of the CDase TIM ... and position. The N-terminal domains of the trehalohydrolase [35] and the isoamylase [36] have a similar chain fold to that of CDase and the TVA-II group, but they are barely related toany of...

Báo cáo khoa học: MicroRNAs and the regulation of ﬁbrosis potx

... within the 3¢-UTR of target genes. The specificity of the miRNA guide strand is thought to bemediated by the ‘seed’ region localized between resi-dues 2 and 8 at the 5¢ end [5–7], and the specificity ... organs including the heart, kidney, liver and lung. In this review, we summarize our current understanding of the role of miRNAs in the development of tissue fibrosis and their potential asnovel ... the development of multiple diseases. Fibrosis is character-ized by the excess deposition of extracellular matrix(ECM) components, which is the end result of animbalance of metabolism of the...

Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx

... observed in the epithelial cells of the tongue and esophagus, in the gastric glands and at the base of the villi in jejunum. The apparent signal in the outer keratinized layer of the tongue and esophagus ... epithelial cells at the base of the villi.In colon, Aldh1 gene activity was detected in the upperparts of the crypts of Lieberku¨hn, whereas the lowerparts of the crypts, the submucosa and ... sections at the same magniﬁcation. High levels of Adh1 mRNA are observed in the epithelial cells at the base of the intestinalglands in rectum and moderate levels of Adh4 are present in the epithelial...

Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx

... how the second kinase in the cascade determines the time dependence of the activity of the third kinase, we varied the Vmax of the secondkinase reaction and recalculated the concentration of the ... controlled by the kinases or phosphatasesin the system, and whether they are controlled differ-entially by some or all of them. On the basis of the antagonistic action of the kinases and phosphatasesone ... strength; the dur-ation of the signal; the ﬁnal signal strength and the integral signal strength. The summing is over all the processes in the system, and its results are given in the ﬁnal column of...

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