... muscle-specific genes are very similar and containconsensus CArG boxes: CC(A/T)6GG [12]. Despite thesimilarity in their SRF-binding sites, some genes, such asc-fos, are activated in response ... such asa-actin genes, are induced during muscle differentiationthat, in cell culture, usually implies serum withdrawal.Moreover, SRF-dependent immediately early genes are repressed after muscle ... SRF cofactors. Some of these cofactors are tissue-specific, as the muscular Nkx2.5 [15], GATA-4 [16] ormyocardin [17] transcription factors. Other cofactors are regulated by growth-factor transduction...