... novel toxin, AmmTX3 (3823.5 Da), was isolated from the
venom of the scorpion Androctonus mauretanicus. It showed
94% sequence homology with Aa1 from Androctonus aus-
tralis and 91% with BmTX3 from ... Expanding the scorpion toxin a-KTX 15 family with AmmTX3
from
Androctonus mauretanicus
He
´
le
`
ne Vacher
1
, Meriem Alami
3
, Marcel ... culture...
... different animal phyla
[10].
Scorpion a-toxins are classically divided into the follow-
ing three groups: (a) mammal a-toxins that are highly active
on mammals, and display very low toxicity to insects,
e.g. ... limit the problems with backbone dihedrals
of nonGly residues, we avoided to aligning the Gly residues
with nonGly residues. The 40 first models (20 in each
protein) were...
... until
the first day of the study period. The staff designated to form
the MET varied between participating centers because of
local circumstances. The study protocol required that the
MET ... had the responsibility for
maintaining staff awareness.
Outcomes: The primary outcome was a composite index of
the incidence (events divided by the number of eligible
patients ad...
... between terms.
The first article, presented in this issue, covers the presentation
and summary of data. It is unlikely that the material covered by
this article will be entirely new to any reader but ... it is hoped that there will still be useful
lessons to be learned, for example the underlying assumptions
of a hypothesis test that were not fully appreciated, or some
previously unre...
...
Furthermore, with the advent of new DES systems, it
is important to elucidate any differences in efficacy
and safety when utilizing the currently availab l e
DESs. Therefore, we report the ... patients in
the ZES treated group were prematurely taken off
their antiplatelet therapy and this likely played a role
in the observed MACE events. Also noteworthy was
the observation...
... interpreted with caution.
The question is whether these apparently H.
pylori-negative subjects were indeed truly negative or
they eventually led to loss of the infection due to sever
gastric atrophy. ... Nagoya University
between January 1998 and June 2000. Informed
consent was obtained from all the subjects. This study
protocol was approved by the Ethics Committee of the...
... the catalytic efficiency of the
enzyme, the cold adaptation of the enzyme could not be
attributed to the presence of the Gly cluster in this element.
The present study supports the idea that the ... resulted in an enzyme with slightly lower stability.
On the other hand, in the double mutant G261A /Y2 69A the
additional replacement of Tyr269 by Ala restores the
stabi...
... guanidine hydro-
chloride (GdnHCl), urea or elevated temperatures, they
destroy the tertiary structure of proteins which results in the
loss of enzymatic activity. Regarding the secondary struc-
ture ... triflu-
oroethanol the proteolytic susceptibility of RNase A
strongly increases, which coincides with the disruption of
the tertiary structure of the RNase A molecule, in 20%
t...
... previously. The nature
of the multiplicity of these high-spin signals is not known,
but it does not reflect a difference in enzymatic activity. As
expected for heme enzymes, the ferric heme in the enzyme ... and hypochlorite. The
reaction mechanism of WF10 with hemoproteins may be
similar to the enzymatic reaction of chlorite with chlorite
dismutase. Thus, the study of chlori...
... Pharmacy, University of Patras, Greece
A new human/rat CRH analogue has been synthesized
using the Fmoc/tBu solid-phase synthetic protocol. The
sequence of the new peptide differs from the original ... 3A shows the family of 40 structures
and Table 1 contains a summary of statistical data indica-
ting the quality of the 40 models and the average energy-
minimized structure....