... among the members of the Lad1 terminal clade but which arefunctionally different from those present in other SDHs, arelocated at the facing rims of the two domains of the proteinthat form the ... in polyol binding in the SDH [25] are also absolutely conserved in Lad1, and thus cannot determine the binding efficacy of hexitols and pentitols. On the other hand, many of the amino acids addressed ... However,evidence is missing so far that the enzyme is indeedresponsible for the metabolism of any of these polyols in vivo.Totestthis,wemadeuseofaH. jecorinarecombinant strain in which the lad1 coding region...