Báo cáo khoa học: b3-Adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat pptx

... thatb3-adrenoceptors play a major role in the appearance of brown adipocytes in white fat and suggest that the brown adipocytes present in white fat diﬀer from those in brown fat. Keywords: adipose tissue; ... of the sympathetic nervoussystem, induces heat production in BAT [3,4] and lipolysis in WAT [5]. The effects of norepinephrine released at the nerve endings are mediated in brown and white adipocytes mainly ... immunohistochemistry in the WAT The density of multilocular cells was measured in genitalWAT sections. As shown in Fig. 1, in the WAT of C57 WT mice maintained at 24 °C, only 1.1% of the total adipocytes was...

Tài liệu Báo cáo khoa học: "From HOPE en I''''ESPERANCE On the Role of Computational Neurolinguistics in Cross-Language Studies " pptx

... disambiguated word meaning. It is the in interaction of the results of these asynchronous processes that the process of comprehension is defined. The processes are independent of the know- ledge ... affected. The study includes off-line picture naming which forces use of articles in all of the above contexts, as well as on-line production of these morphemes in an attempt to determine in which ... HOPE, the determination of the phonetic representation of a recognized word determines the breadth of active competition amon 9 meanings for subsequent time intervals of the process. Depending...

Báo cáo khoa học: A novel mass spectrometric approach to the analysis of hormonal peptides in extracts of mouse pancreatic islets ppt

... performed in orderto get an overview of the many compounds of the pancreaticislet extract (Fig. 1a). The prominent signals in the spectrumoriginated from products of proinsulin. Two insulin variantsare ... is produced in the pancreatic a-cells and in the L-cells of the intestines. The post-translational process-ing of proglucagon is tissue-speciﬁc. In the pancreatica-cells, the main products ... 60–80% of the islets and as insulin makes up almost20% of the proteins in the b-cells, proinsulin-derivedpeptides can be expected to constitute quantitatively pre-dominant components of the extracts....

Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx

... in the triggering of an immuneresponse and in the natural process of elimination of activated antigen-presenting cells and termination of the immune response [90].HealingInfection and injury ... function.Expression of defensin-coding andcathelicidin-coding genes The final combination of peptides at a specific locationreflects the signaling of pattern ⁄ pathogen-associatedreceptors as well as that of other ... an in ammatory disease of the small intestine and ⁄ or the colon. As mentionedalready, in the small intestine, the pathogenesis is asso-ciated with a reduced expression of the Wnt signalingpathway...

Tài liệu Báo cáo khoa học: Molecular characterization, phylogenetic relationships, and developmental expression patterns of prion genes in zebraﬁsh (Danio rerio) doc

... lumen[43,44]. Considering the importance of the intestinalbarrier in the process of oral prion infection, this find-ing might help clarify the entry and routing of PrPSc in the early steps of infection. ... dpf in enterocytes of the pos-terior part of the intestine (Fig. 5M,Q,R). This lastfinding should be of interest because in terms of func-tion, the fish intestine is highly regionalized both in ... both in the larva and in the adult [38]. The posterior segment of the fish intestine is the absorption site of intact pro-teins, which might thus escape intracellular degrada-tion [39]. In the mammalian...

Báo cáo khoa học: cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells pdf

... stimu-lation of steroidogenesis using 300 lm AA in the pres-ence of albumin. These different results can beexplained by the fact that protein binding can increase the overall concentration of fatty ... explain the mechanism bywhich in these situations there is a remaining 20% of steroid synthesis, due to the direct effect of AA ⁄AA-CoA produced within the mitochondria by the action of ACS4 ... the inhibition in the induction of ACS4 [28] during the early response and the inhibi-tion of ACS4 and StAR inductions during the sus-tained phase. In both phases, the presence of DBI ⁄ PBR may...

Báo cáo khoa học: Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence doc

... detectable binding. To determine whether the decrease in binding afﬁnity in the other chimeraswas the result of protein instability and misfolding orwas merely a byproduct of the localization of chimeras in ... the rest of the bundle (Fig. 3A). At the same time, the main kinks in the TM helices of rhodopsin (e.g. the functionallyimportant kink in TM6) were preserved in the 3Dmodel of C5aR. Also, the ... patterns of homo-oligomeric cross-linking for C5aR and AT1R-YFP. Because the rate of cross-linking depends on the proximity of the sidegroups, the ﬂexibility of the structures containing the cysteine...

Báo cáo khoa học: "Last but Definitely not Least: On the Role of the Last Sentence in Automatic Polarity-Classification" pdf

... compared their results. In the first experiment we exam-ined the readers’ rating of the polarity of reviews in their entirety, while in the second experiment we examined the readers’ rating of the ... is, there-fore, of evaluative nature. To best communicate this affect, the DT should appear at the end of the review (instead of the beginning of the re-view) as a means of recapitulating the ... recapitulating the point of the message, thereby guaranteeing that it is fully understood by the readership. Indeed, the cognitive prominence of informa-tion in final position - the recency-effect...

Báo cáo khoa học: From meiosis to postmeiotic events: Alignment and recognition of homologous chromosomes in meiosis ppt

... microtubule-organizingcenter in fungi), and a dynein protein motor [13,14]. The telomeres remain clustered at the leading edge of the moving nucleus throughout the movements [13,15].Observation of homologous ... promote their contact [16]. In the early stages, the arm regions of homologous chromo-somes become close to each other independently of recombination (in the absence of Rec12), and thesecontacts ... promoting homologouspairing by reducing the freedom of movement of chro-mosomes within the nucleus. Subsequently, oscillatorymovements of the entire nucleus occur in Schiz. pombe. In some other...

Tài liệu Báo cáo khoa học: An engineered disulﬁde bridge mimics the effect of calcium to protect neutral protease against local unfolding docx

... Ger-many). The amount of intact protein was calculated from the intensity of the protein band.Autoproteolysis in sample solutions containing <20lgÆmL)1protein was followed by determining the ... the introduction of the disulﬁde bridge (at5mm CaCl2and 25 ° C) is obtained. The in uence of calcium ions on the unfoldingkinetics The in uence of the calcium ion concentration onunfolding ... increase in the Gibbs free energy of activation of unfolding undernative conditions. Using the linear extrapolation model[27], the rate constant for the unfolding of G8C ⁄ N60C in the absence of...

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