... Follistatin, Chordin and Noggin[12]. These proteins are antagonists of BMP and othermembers of the TGF-b family, binding to and inhibit-ing these signaling molecules from binding to theirreceptors ... theirreceptors in the extracellular space, thus inhibiting ven-tralizing activities. Of these proteins, Chordin has along-range effect. In Xenopus, expression of the chordingene is localized to the dorsal ... forsome time.Other factors affecting the BMPpathwayFactors inhibiting BMP2b, other than direct bindingproteins such as Noggin and Chordin, also affectdorsoventral patterning. One example...