... occur in the presence of thiophilic cations such as Mn2+,Zn2+,orCd2+ ,in increasing order (the rescue effect). Analysis of thesetypes of interaction led to a better understanding of the mechanistic ... s, making kinetic analysisimpossible. Whereas the P8 substitution had only aminor effect both in the presence of Mg2+ and in the presence of Mn2+, causing a 30–60% increase in krel, the ... the P5 phosphate of adenosine at position 5, and the oxy-gen atom of the 6-carbonyl group of the subsequentnucleoside (G6). Our model of the metal-binding site in the catalytic core of deoxyribozyme...